97久久久精品综合88久久_亚洲国产精品一_久热热国产久热_97操操操_北条麻妃在线免费观看_精品国自产拍天天拍

掃碼關注公眾號           掃碼咨詢技術支持           掃碼咨詢技術服務
  
客服熱線:400-901-9800  客服QQ:4009019800  技術答疑  技術支持  質量反饋  關于我們  聯系我們
日本一区二区三区视频中文字幕,精品九九九九,欧美性史
首頁 > 產品中心 > 標記一抗 > 產品信息
Rabbit Anti-phospho-ATF2 (Thr69/71)/Gold Conjugated antibody (bs-3033R-Gold)
訂購熱線:400-901-9800
訂購郵箱:sales@bioss.com.cn
訂購QQ:  400-901-9800
技術支持:techsupport@bioss.com.cn
說 明 書: 100ul(10nm  15nm  35nm
100ul/2980.00元
大包裝/詢價
產品編號 bs-3033R-Gold
英文名稱 Rabbit Anti-phospho-ATF2 (Thr69/71)/Gold Conjugated antibody
中文名稱 膠體金標記的磷酸化活化復制因子2抗體
別    名 ATF2 (phospho T69 + T71); ATF2 (phospho Thr69 + Thr71); p-ATF2 (T69 + T71); p-ATF2 (Thr69 + Thr71); CREB 2; HB 16;Activating Transcription Factor 2; ATF 2; Atf-2; ATF2 protein; cAMP Response Element Binding Protein 2; cAMP response element binding protein CRE BP1; cAMP-dependent transcription factor ATF-2; cAMP-responsive element-binding protein 2; CRE BP1; CRE-BP; CREB 2; CREB2; CREBP1; Cyclic AMP dependent transcription factor ATF 2; Cyclic AMP-responsive; ATF2_HUMAN.  
規格價格 100ul/2980元 購買        大包裝/詢價
說 明 書 100ul(10nm  15nm  35nm
產品類型 磷酸化抗體 
研究領域 免疫學  染色質和核信號  轉錄調節因子  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應 (predicted: Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Rabbit, )
產品應用 IEM=1:20-200 ICA=1:20-200 ChIP=1:20-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 45kDa
性    狀 Lyophilized or Liquid
濃    度 0.4mg/ml
免 疫 原 KLH conjugated Synthesised phosphopeptide derived from human ATF2 around the phosphorylation site of Thr69/71
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.02M TBS(pH8.2) with 1% BSA, 0.03% Proclin300.
保存條件 Store at 2-8 oC for 3-6 months. Avoid repeated freeze/thaw cycles.
產品介紹 background:
ATF2 is a member of the ATF/CREB family of basic region leucine zipper DNA binding proteins that regulates transcription by binding to a consensus cAMP response element (CRE) in the promoter of various viral and cellular genes. Many of these genes are important in cell growth and differentiation, and in stress and immune responses. ATF2 is a nuclear protein that binds DNA as a dimer and can form dimers with members of the ATF/CREB and Jun/Fos families. It is a stronger activator as a heterodimer with cJun than as a homodimer. Several isoforms of ATF2 arise by differential splicing. The stable native full length ATF2 is transcriptionally inactive as a result of an inhibitory direct intramolecular interaction of its carboxy terminal DNA binding domain with the amino terminal transactivation domain. Following dimerization ATF2 becomes a short lived protein that undergoes ubiquitination and proteolysis, seemingly in a protein phosphatase-dependent mechanism. Stimulation of the transcriptional activity of ATF2 occurs following cellular stress induced by several genotoxic agents, inflammatory cytokines, and UV irradiation. This activation requires phosphorylation of two threonine residues in ATF2 by both JNK/SAP kinase and p38 MAP kinase. ATF2 is abundantly expressed in brain.

Subunit:
Binds DNA as a dimer and can form a homodimer in the absence of DNA. Can form a heterodimer with JUN. Interacts with SMAD3 and SMAD4. Binds through its N-terminal region to UTF1 which acts as a coactivator of ATF2 transcriptional activity.

Subcellular Location:
Nucleus.

Tissue Specificity:
Abundant expression seen in the brain.

Post-translational modifications:
Phosphorylation of Thr-69 by MAPK14 and MAPK11, and at Thr-71 by MAPK1/ERK2, MAPK3/ERK1, MAPK11, MAPK12 and MAPK14 in response to external stimulus like insulin causes increased transcriptional activity. Phosphorylated by PLK3 following hyperosmotic stress. Also phosphorylated and activated by JNK and CaMK4.

Similarity:
Belongs to the bZIP family. ATF subfamily.
Contains 1 bZIP domain.
Contains 1 C2H2-type zinc finger.

Database links:

Entrez Gene: 1386 Human

Entrez Gene: 100047997 Mouse

Entrez Gene: 11909 Mouse

Entrez Gene: 81647 Rat

Omim: 123811 Human

SwissProt: P15336 Human

SwissProt: P16951 Mouse

SwissProt: Q00969 Rat

Unigene: 592510 Human

Unigene: 209903 Mouse

Unigene: 9825 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

轉錄調節因子(Transcriptin Regulators)
版權所有 2004-2026 www.kastlife.cn 北京博奧森生物技術有限公司
通過國際質量管理體系ISO 9001:2015 GB/T 19001-2016    證書編號: 00124Q34771R2M/1100
通過國際醫療器械-質量管理體系ISO 13485:2016 GB/T 42061-2022    證書編號: CQC24QY10047R0M/1100
京ICP備05066980號-1         京公網安備110107000727號
主站蜘蛛池模板: 9久9久女女热精品视频在线观看 | 把女人弄爽特黄a大片777 | 斗破苍穹年番观看免费完整观看 | 艳妇乳肉豪妇荡乳AV无码福利 | 精品久久综合1区2区3区激情 | 亚洲色成人四虎在线观看 | av免费网 | 国产性色强伦免费看视频 | 国产亚洲精品美女久久久久久久久久 | 欧美成人精品一区二区男人看 | 日本高清不卡中文字幕免费 | 久久婷婷成人综合色综合 | 精品国产91九色蝌蚪 | 亚洲国产成人精品无码区在线网站 | 午夜影院一区二区 | 一区二区三区视频免费视频观看网站 | 日本v片 | 91九色论坛 | 激情久久久久久久 | 欧美狂野乱码一二三四区 | 国产一级大毛片 | 一区二区视频免费 | 国产精品久久久久久AV福利 | 国产裸体舞一区二区三区 | 无码专区—va亚洲v专区 | 日本高清视频在线观看 | 国产日本在线视频 | 我是刑警34集全免费 | 国产白嫩受无套呻吟 | 亚洲毛茸茸浓毛多水多 | www.日韩 | 日本免费三级网站 | 亚洲视频色| 暗夜在线观看 | 91肥熟 | 中文字幕视频一区二区三区久 | 红杏出墙在线 | 99久久免费精品国产72精品九九 | 欧美xxxx色视频在线观看 | 337p日本欧洲亚洲大胆艺术图 | 在线观看成人高清a |