97久久久精品综合88久久_亚洲国产精品一_久热热国产久热_97操操操_北条麻妃在线免费观看_精品国自产拍天天拍

掃碼關注公眾號           掃碼咨詢技術支持           掃碼咨詢技術服務
  
客服熱線:400-901-9800  客服QQ:4009019800  技術答疑  技術支持  質量反饋  關于我們  聯系我們
h无码精品动漫尤物,亚洲乱理伦片在线观看中字,99婷婷狠狠成为人免费视频
首頁 > 產品中心 > 標記一抗 > 產品信息
Rabbit Anti-Aurora A/BF594 Conjugated antibody (bs-2749R-BF594)
訂購熱線:400-901-9800
訂購郵箱:sales@bioss.com.cn
訂購QQ:  400-901-9800
技術支持:techsupport@bioss.com.cn
說 明 書: 100ul  
100ul/2980.00元
大包裝/詢價
產品編號 bs-2749R-BF594
英文名稱 Rabbit Anti-Aurora A/BF594 Conjugated antibody
中文名稱 BF594標記的有絲分裂激酶A抗體
別    名 Aurora A (phospho-Thr288); p-Aurora A(T288); AIK; ARK-1; ARK1; AURA; AURKA; Aurora 2; Aurora A; Aurora A; Aurora Family Kinase 1; aurora kinase A; Aurora Related Kinase 1; Aurora-related kinase 1; Aurora/IPL1 Like Kinase; Aurora/IPL1 Related Kinase 1; Aurora/IPL1-related kinase 1; AURORA2; AYK1; BRAK; Breast Tumor Amplified Kinase; Breast tumor-amplified kinase; BTAK; hARK1; IAK; IPL1 Aurora Related Kinase 1; IPL1 Related Kinase; MGC34538; OTTHUMP00000031340; OTTHUMP00000031341; OTTHUMP00000031342; OTTHUMP00000031343; OTTHUMP00000031344; OTTHUMP00000031345; OTTHUMP00000166071; OTTHUMP00000166072; PPP1R47; Protein phosphatase 1, regulatory subunit 47; Serine/threonine kinase 15; Serine/threonine kinase 6; Serine/threonine kinase; Serine/threonine kinase; Serine/threonine-protein kinase 15; Serine/threonine-protein kinase 6; Serine/threonine-protein kinase aurora-A; STK15; STK6; STK6_HUMAN; STK7.  
規格價格 100ul/2980元 購買        大包裝/詢價
說 明 書 100ul  
研究領域 腫瘤  細胞生物  細胞周期蛋白  激酶和磷酸酶  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應 (predicted: Human, Mouse, Rat, Pig, Cow, Horse, Rabbit, )
產品應用 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 48kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human Auroa A
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產品介紹 background:
Aurora A plays a role in cell cycle regulation during anaphase and/or telophase, in relation to the function of the centrosome/spindle pole region during chromosome segregation. Aurora A plays a key role during tumor development and progression and is overexpressed in many human cancers including breast, ovarian and colorectal. Aurora A is viewed as a potential target for anticancer drug treatment.

Function:
Contributes to the regulation of cell cycle progression. Required for normal mitosis. Associates with the centrosome and the spindle microtubules during mitosis and functions in centrosome maturation, spindle assembly, maintenance of spindle bipolarity, centrosome separation and mitotic checkpoint control. Phosphorylates numerous target proteins, including ARHGEF2, BRCA1, KIF2A, NDEL1, PARD3, PLK1 and BORA. Regulates KIF2A tubulin depolymerase activity (By similarity). Required for normal axon formation. Plays a role in microtubule remodeling during neurite extension. Important for microtubule formation and/or stabilization.

Subunit:
Interacts with FBXL7 (By similarity). Interacts with CPEB1, JTB, TACC1, TPX2, PPP2CA, as well as with the protein phosphatase type 1 (PP1) isoforms PPP1CA, PPP1CB and PPP1CC. Interacts also with its substrates ARHGEF2, BORA, BRCA1, KIF2A, PARD3, and p53/TP53. Interaction with BORA promotes phosphorylation of PLK1. Interacts with PIFO. Interacts with GADD45A, competing with its oligomerization. Interacts (via C-terminus) with AUNIP (via C-terminus). Identified in a complex with AUNIP and NIN. Interacts with FRY; this interaction facilitates AURKA-mediated PLK1 phosphorylation.

Subcellular Location:
Cytoplasm.

Tissue Specificity:
Highly expressed in testis and weakly in skeletal muscle, thymus and spleen. Also highly expressed in colon, ovarian, prostate, neuroblastoma, breast and cervical cancer cell lines.

Post-translational modifications:
Activated by phosphorylation at Thr-288; this brings about a change in the conformation of the activation segment. Phosphorylation at Thr-288 varies during the cell cycle and is highest during M phase. Autophosphorylated at Thr-288 upon TPX2 binding. Phosphorylated upon DNA damage, probably by ATM or ATR. Ubiquitinated by CHFR, leading to its degradation by the proteasome (By similarity). Ubiquitinated by the anaphase-promoting complex (APC), leading to its degradation by the proteasome.

Similarity:
Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.
Aurora subfamily. Contains 1 protein kinase domain.

Database links:

Entrez Gene: 6790 Human

Entrez Gene: 20878 Mouse

Omim: 603072 Human

SwissProt: O14965 Human

SwissProt: P97477 Mouse

Unigene: 250822 Human

Unigene: 249363 Mouse



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

細胞的有絲分裂是生物體最基本的生命活動過程,能將復制的基因組精確地分配到下一代子細胞中,在長期的生物進化過程中,生物體形成了一整套完善的監測機制以確保遺傳物質精確地分配到子細胞中。
Aurora激酶(極光激酶)是細胞有絲分裂調控網絡中的一類重要的絲氨酸/蘇氨酸激酶,Aurora酪氨酸激酶B也是絲氨酸/蘇氨酸激酶家族成員之一,目前分為aurora A,B及C。
版權所有 2004-2026 www.kastlife.cn 北京博奧森生物技術有限公司
通過國際質量管理體系ISO 9001:2015 GB/T 19001-2016    證書編號: 00124Q34771R2M/1100
通過國際醫療器械-質量管理體系ISO 13485:2016 GB/T 42061-2022    證書編號: CQC24QY10047R0M/1100
京ICP備05066980號-1         京公網安備110107000727號
主站蜘蛛池模板: 国产精品色拉拉 | 成人一级视频 | 麻豆国产手机福利看片 | 99热99热99 | 99视频国产精品免费观看 | 国产二级一片内射视频播放 | 欧美视频在线观看 | 四虎影视永久免费在线观看 | 日韩AV东京社区男人的天堂 | 可以免费看av的网站 | 日韩免费在线 | 亚洲欧洲日本无在线码天堂 | 99久久精品免费观看国产 | 天天综合网久久综合网 | 国产中文区4幕区2023 | 欧美黄色一级片在线观看 | 7799国产精品久久99 | 亚洲欧美精品一中文字幕 | 国产系列视频二区 | 免费高清一区二区三区 | 99久久综合狠狠综合 | 亚洲女同一区 | 91九色超碰| 免费无码中文A级毛片 | 欧美精欧美乱码一二三四区 | 亚洲精品性| 欧美成人看片一区二三区图文 | 国产熟女AA级毛片 | 一区二区最新免费视频 | 久久精品人人爽人人爽 | 高H猛烈失禁潮喷A片在线观看 | 97人妻人人做人碰人人添 | 国产在线a视频 | 天堂网www天堂在线资源库 | 好看的国产精品视频 | 成人综合在线观看视频 | 欧美秋霞| 中国XXXXXL19学生 | 蜜桃久久精品乱码一区二区 | 91精品一区二区三区综合在线爱 | baoyu123成人免费看视频 |