97久久久精品综合88久久_亚洲国产精品一_久热热国产久热_97操操操_北条麻妃在线免费观看_精品国自产拍天天拍

掃碼關注公眾號           掃碼咨詢技術支持           掃碼咨詢技術服務
  
客服熱線:400-901-9800  客服QQ:4009019800  技術答疑  技術支持  質量反饋  關于我們  聯系我們
91深夜福利视频,蜜桃久久久久久久,欧美高潮又爽又黄又硬又无遮
首頁 > 產品中心 > 標記一抗 > 產品信息
Rabbit Anti-Phospho-cdc25A (Thr507)/BF647 Conjugated antibody (bs-3093R-BF647)
訂購熱線:400-901-9800
訂購郵箱:sales@bioss.com.cn
訂購QQ:  400-901-9800
技術支持:techsupport@bioss.com.cn
說 明 書: 100ul  
100ul/2980.00元
大包裝/詢價
產品編號 bs-3093R-BF647
英文名稱 Rabbit Anti-Phospho-cdc25A (Thr507)/BF647 Conjugated antibody
中文名稱 BF647標記的磷酸化細胞分裂周期蛋白25抗體
別    名 cdc25A (Phospho Thr507); cdc25A (Phospho T507); Cdc 25a; CDC25A2; Cell division cycle 25 homolog A (S. pombe); Cell division cycle 25A; Cell division cycle 25A isoform a; Cell division cycle 25A isoform b; D9Ertd393e; Dual specificity phosphatase CDC25A; EC 3.1.3.48; M phase inducer phosphatase 1; MGC115549; CDC25A; CDC25A2 CAG isoform; M-phase inducer phosphatase 1; MPIP1_HUMAN.  
規格價格 100ul/2980元 購買        大包裝/詢價
說 明 書 100ul  
產品類型 磷酸化抗體 
研究領域 細胞生物  信號轉導  細胞凋亡  細胞周期蛋白  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應 Mouse,  (predicted: Human, Rat, Chicken, Dog, Cow, )
產品應用 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 59kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated Synthesised phosphopeptide derived from human cdc25A around the phosphorylation site of Thr506 [SR(p-T)WA]
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產品介紹 background:
CDC25A is a member of the CDC25 family of phosphatases. CDC25A is required for progression from G1 to the S phase of the cell cycle. It activates the cyclin-dependent kinase CDC2 by removing two phosphate groups. CDC25A is specifically degraded in response to DNA damage, which prevents cells with chromosomal abnormalities from progressing through cell division. CDC25A is an oncogene, although its exact role in oncogenesis has not been demonstrated. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Function:
Tyrosine protein phosphatase which functions as a dosage-dependent inducer of mitotic progression. Directly dephosphorylates CDK1 and stimulates its kinase activity. Also dephosphorylates CDK2 in complex with cyclin E, in vitro.

Subunit:
Interacts with CCNB1/cyclin B1. Interacts with YWHAE/14-3-3 epsilon when phosphorylated. Interacts with CUL1 specifically when CUL1 is neddylated and active. Interacts with BTRC/BTRCP1 and FBXW11/BTRCP2. Interactions with CUL1, BTRC and FBXW11 are enhanced upon DNA damage. Interacts with PIM1. Interacts with CHEK2; mediates CDC25A phosphorylation and degradation in response to infrared-induced DNA damages.

Post-translational modifications:
Phosphorylated by CHEK1 on Ser-76, Ser-124, Ser-178, Ser-279, Ser-293 and Thr-507 during checkpoint mediated cell cycle arrest. Also phosphorylated by CHEK2 on Ser-124, Ser-279, and Ser-293 during checkpoint mediated cell cycle arrest. Phosphorylation on Ser-178 and Thr-507 creates binding sites for YWHAE/14-3-3 epsilon which inhibits CDC25A. Phosphorylation on Ser-76, Ser-124, Ser-178, Ser-279 and Ser-293 may also promote ubiquitin-dependent proteolysis of CDC25A by the SCF complex. Phosphorylation of CDC25A at Ser-76 by CHEK1 primes it for subsequent phosphorylation at Ser-79, Ser-82 and Ser-88 by NEK11. Phosphorylation by NEK11 is required for BTRC-mediated polyubiquitination and degradation. Phosphorylation by PIM1 leads to an increase in phosphatase activity. Phosphorylated by PLK3 following DNA damage, leading to promote its ubiquitination and degradation.
Ubiquitinated by the anaphase promoting complex/cyclosome (APC/C) ubiquitin ligase complex that contains FZR1/CDH1 during G1 phase leading to its degradation by the proteasome. Ubiquitinated by a SCF complex containing BTRC and FBXW11 during S phase leading to its degradation by the proteasome. Deubiquitination by USP17L2/DUB3 leads to its stabilization.

Similarity:
Belongs to the MPI phosphatase family.
Contains 1 rhodanese domain.

Database links:

Entrez Gene: 993 Human

Entrez Gene: 12530 Mouse

Entrez Gene: 171102 Rat

Omim: 116947 Human

SwissProt: P30304 Human

SwissProt: P48964 Mouse

SwissProt: P48965 Rat

Unigene: 437705 Human

Unigene: 307103 Mouse

Unigene: 11390 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

CDC25家族的組成哺乳動物中CDC25家族一共包括3種同源異構體(CDC25A、CDC25B、CDC25C),約有50%的序列同源,是一組在細胞周期調控中發揮巨大作用的蘇/酪氨酸雙功能酶 。不同的CDC25家族蛋白在細胞周期中的作用時相亦有差異,CDC25A和CDC25C分別在S期和M期發揮主要作用。
版權所有 2004-2026 www.kastlife.cn 北京博奧森生物技術有限公司
通過國際質量管理體系ISO 9001:2015 GB/T 19001-2016    證書編號: 00124Q34771R2M/1100
通過國際醫療器械-質量管理體系ISO 13485:2016 GB/T 42061-2022    證書編號: CQC24QY10047R0M/1100
京ICP備05066980號-1         京公網安備110107000727號
主站蜘蛛池模板: 奇米777四色成人影视 | 4455四色永久在线 | 免费黄色福利网站 | 一级做性色a爱片久久毛片欧 | 强壮的公次次弄得我高潮a片日本 | 视频在线日韩 | 秋霞午夜av一区二区三区 | 亚州成人在线观看 | 国产69精品久久99不卡免费版 | 国产在线精品无码不卡手机免费 | 我要看免费毛片 | 伊人久艹| 一级少妇性生话片 | 最新日韩AV网址在线观看 | 成年人黄色影院 | 国产大陆亚洲精品国产 | 免费人成再在线观看网站 | 日本午夜高清 | 国产性一交一乱一伦一色一情 | 欧美一区a| av黄色在线 | 亚洲av日韩av无码专区 | 大地资源二中文在线观看官网 | 488成人啪啪片 | 一级做性色a爰片久久毛片免费 | 欧美制服第一页 | 亚洲日韩av无码一区二区三区人 | 成人免费高清在线播放 | 天堂资源在线观看免费高清视频 | 国产永久伊人影院 | 欧美日韩激情一区二区 | 亚洲韩国欧洲国产日产av | 国产成人综合亚洲AV第一页 | 夜夜高潮夜夜爽夜夜爱爱一区 | 久草在线视频精品 | 日本中文字幕在线免费观看视频 | 无码免费一区二区三区免费播放 | 前夜40集连续剧免费观看国语高清 | 国产高清一区二区三区视频 | 成人短篇合集t×t | 日本不卡一区二区三区四区 |