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Rabbit Anti-cofilin/BF647 Conjugated antibody (bs-2759R-BF647)
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說 明 書: 100ul  
100ul/2980.00元
大包裝/詢價
產品編號 bs-2759R-BF647
英文名稱 Rabbit Anti-cofilin/BF647 Conjugated antibody
中文名稱 BF647標記的絲切蛋白抗體
別    名 18 kDa phosphoprotein; CFL 1; CFL; CFL1; Cofilin 1; Cofilin 1 non muscle; Cofilin non muscle isoform; p18; COF1_HUMAN.  
規(guī)格價格 100ul/2980元 購買        大包裝/詢價
說 明 書 100ul  
研究領域 腫瘤  免疫學  生長因子和激素  轉錄調節(jié)因子  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應 Human, Rat,  (predicted: Mouse, Chicken, Dog, Pig, Cow, Rabbit, )
產品應用 Flow-Cyt=1:50-200 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 18kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 Synthetic peptide from the human cofilin conjugated to KLH
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產品介紹 background:
The protein encoded by this gene can polymerize and depolymerize F-actin and G-actin in a pH-dependent manner. Increased phosphorylation of this protein by LIM kinase aids in Rho-induced reorganization of the actin cytoskeleton. Cofilin is a widely distributed intracellular actin-modulating protein that binds and depolymerizes filamentous F-actin and inhibits the polymerization of monomeric G-actin in a pH-dependent manner. It is involved in the translocation of actin-cofilin complex from cytoplasm to nucleus.[supplied by OMIM, Apr 2004].

Function:
Controls reversibly actin polymerization and depolymerization in a pH-sensitive manner. It has the ability to bind G- and F-actin in a 1:1 ratio of cofilin to actin. It is the major component of intranuclear and cytoplasmic actin rods.

Subunit:
Can bind G- and F-actin in a 1:1 ratio of cofilin to actin. It is a major component of intranuclear and cytoplasmic actin rods.

Subcellular Location:
Nucleus matrix. Cytoplasm, cytoskeleton. Almost completely in nucleus in cells exposed to heat shock or 10% dimethyl sulfoxide.

Tissue Specificity:
Widely distributed in various tissues.

Post-translational modifications:
Inactivated by phosphorylation on Ser-3. Phosphorylated on Ser-3 in resting cells. Dephosphorylated by PDXP/chronophin; this restores its activity in promoting actin filament depolymerization. The phosphorylation of Ser-24 may prevent recognition of the nuclear localization signal.

Similarity:
Belongs to the actin-binding proteins ADF family.
Contains 1 ADF-H domain.

Database links:

Entrez Gene: 1072 Human

Entrez Gene: 12631 Mouse

Entrez Gene: 29271 Rat

Omim: 601442 Human

SwissProt: P23528 Human

SwissProt: P18760 Mouse

SwissProt: P45592 Rat

Unigene: 170622 Human

Unigene: 329655 Mouse

Unigene: 11675 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

絲切蛋白(cofilin)是細胞骨架塑形的重要調節(jié)因素,其主要功能是分解肌動蛋白微絲和增加肌動蛋白單體從肌動蛋白微絲的末端解離的速度,從而促進肌動蛋白微絲的循環(huán),是目前為止已發(fā)現(xiàn)的肌動蛋白結合蛋白家族中唯一能夠改變肌動蛋白微絲扭曲結構的蛋白.
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