97久久久精品综合88久久_亚洲国产精品一_久热热国产久热_97操操操_北条麻妃在线免费观看_精品国自产拍天天拍

掃碼關注公眾號           掃碼咨詢技術支持           掃碼咨詢技術服務
  
客服熱線:400-901-9800  客服QQ:4009019800  技術答疑  技術支持  質量反饋  關于我們  聯系我們
国产91会所女技师在线观,天堂网av2014,精品自拍最新换脸综合网站
首頁 > 產品中心 > 標記一抗 > 產品信息
Rabbit Anti-CACH2/CACNA1C/PE-Cy5.5 Conjugated antibody (bs-2776R-PE-Cy5.5)
訂購熱線:400-901-9800
訂購郵箱:sales@bioss.com.cn
訂購QQ:  400-901-9800
技術支持:techsupport@bioss.com.cn
說 明 書: 100ul  
100ul/2980.00元
大包裝/詢價
產品編號 bs-2776R-PE-Cy5.5
英文名稱 Rabbit Anti-CACH2/CACNA1C/PE-Cy5.5 Conjugated antibody
中文名稱 PE-Cy5.5標記的L型鈣通道蛋白抗體
別    名 CACH 2;CACH2; CACN 2; CACN2; CACNA1C; CACNL1A1; Calcium channel cardic dihydropyridine sensitive alpha 1 subunit; Calcium channel L type alpha 1 polypeptide isoform 1 cardiac muscle; Calcium channel voltage dependent L type alpha 1C subunit; CaV1.2; CCHL1A1; DHPR alpha 1 subunit; TS; Voltage dependent L type calcium channel alpha 1C subunit; Voltage dependent L type calcium channel subunit alpha 1C; Voltage gated calcium channel alpha subunit Cav1.2; Voltage gated calcium channel subunit alpha Cav1.2; CAC1C_HUMAN.   
規格價格 100ul/2980元 購買        大包裝/詢價
說 明 書 100ul  
研究領域 腫瘤  細胞生物  神經生物學  信號轉導  通道蛋白  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應 (predicted: Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit, )
產品應用 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 239kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human CACH2
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產品介紹 background:
The receptor for the 1,4-dihydropyrodine (DHPR) class of Ca2+ channel is most abundant in the transverse tubular membranes of skeletal muscle. DHRP is essential in excitation-contraction (E-C) coupling and has been proposed to have a dual function as a calcium channel and voltage sensor. Skeletal muscle DHRP consists of four subunits: alpha1 (170kDa); alpha2 (175kDa non-reduced, 150kDa reduced); beta (52kDa) and gamma (32kDa).

Function:
Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1C gives rise to L-type calcium currents. Long-lasting (L-type) calcium channels belong to the 'high-voltage activated' (HVA) group. They are blocked by dihydropyridines (DHP), phenylalkylamines, benzothiazepines, and by omega-agatoxin-IIIA (omega-Aga-IIIA). They are however insensitive to omega-conotoxin-GVIA (omega-CTx-GVIA) and omega-agatoxin-IVA (omega-Aga-IVA). Calcium channels containing the alpha-1C subunit play an important role in excitation-contraction coupling in the heart. The various isoforms display marked differences in the sensitivity to DHP compounds. Binding of calmodulin or CABP1 at the same regulatory sites results in an opposit effects on the channel function.

Subunit:
Voltage-dependent calcium channels are multisubunit complexes, consisting of alpha-1, alpha-2, beta and delta subunits in a 1:1:1:1 ratio. The channel activity is directed by the pore-forming and voltage-sensitive alpha-1 subunit. In many cases, this subunit is sufficient to generate voltage-sensitive calcium channel activity. The auxiliary subunits beta and alpha-2/delta linked by a disulfide bridge regulate the channel activity. Interacts with CACNA2D4. Interacts (via the N-terminus and the C-terminal C and IQ motifs) with CABP1. The binding via the C motif is calcium independent whereas the binding via IQ requires the presence of calcium and is mutually exclusive with calmodulin binding. The binding to the cytoplasmic N-terminal domain is calcium independent but is essential for the channel modulation. Interacts (via C-terminal CDB motif) with CABP5; in a calcium-dependent manner (By similarity).

Subcellular Location:
Membrane. Cell membrane. The interaction between RRAD and CACNB2 regulates its trafficking to the cell membrane.

Tissue Specificity:
Expressed in brain, heart, jejunum, ovary, pancreatic beta-cells and vascular smooth muscle. Overall expression is reduced in atherosclerotic vascular smooth muscle.

Post-translational modifications:
Phosphorylation by PKA activates the channel.

DISEASE:
Defects in CACNA1C are the cause of Timothy syndrome (TS) [MIM:601005]. TS is a disorder characterized by multiorgan dysfunction including lethal arrhythmias, webbing of fingers and toes, congenital heart disease, immune deficiency, intermittent hypoglycemia, cognitive abnormalities and autism.
Defects in CACNA1C are the cause of Brugada syndrome type 3 (BRGDA3) [MIM:611875]. A heart disease characterized by the association of Brugada syndrome with shortened QT intervals. Brugada syndrome is a tachyarrhythmia characterized by right bundle branch block and ST segment elevation on an electrocardiogram (ECG). It can cause the ventricles to beat so fast that the blood is prevented from circulating efficiently in the body. When this situation occurs (called ventricular fibrillation), the individual will faint and may die in a few minutes if the heart is not reset.

Similarity:
Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. CACNA1C subfamily.

Database links:

Entrez Gene: 775 Human

Entrez Gene: 12288 Mouse

Entrez Gene: 100144322 Rabbit

Entrez Gene: 24239 Rat

Omim: 114205 Human

SwissProt: Q13936 Human

SwissProt: Q01815 Mouse

SwissProt: P15381 Rabbit

SwissProt: P22002 Rat

Unigene: 118262 Human

Unigene: 436656 Mouse

Unigene: 9827 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

Involvement in disease; Defects in CACNA1C are the cause of Timothy syndrome (TS) . TS is a disorder characterized by multiorgan dysfunction including lethal arrhythmias, webbing of fingers and toes, congenital heart disease, immune deficiency, intermittent hypoglycemia, cognitive abnormalities and autism.
Defects in CACNA1C are the cause of Brugada syndrome type 3 (BRGDA3). A heart disease characterized by the association of Brugada syndrome with shortened QT intervals. Brugada syndrome is a tachyarrhythmia characterized by right bundle branch block and ST segment elevation on an electrocardiogram (ECG). It can cause the ventricles to beat so fast that the blood is prevented from circulating efficiently in the body. When this situation occurs (called ventricular fibrillation), the individual will faint and may die in a few minutes if the heart is not reset.
版權所有 2004-2026 www.kastlife.cn 北京博奧森生物技術有限公司
通過國際質量管理體系ISO 9001:2015 GB/T 19001-2016    證書編號: 00124Q34771R2M/1100
通過國際醫療器械-質量管理體系ISO 13485:2016 GB/T 42061-2022    證書編號: CQC24QY10047R0M/1100
京ICP備05066980號-1         京公網安備110107000727號
主站蜘蛛池模板: 91肥熟 | 亚洲国产精品高清在线第1页 | 国产免费拔擦拔擦8x高清在线人 | 女人15一17毛片 | 国产福利男女XX00视频 | 日日天干夜夜人人添 | 日本精品在线播放 | 成人国产精品一区在线观看播放 | 无码精品人妻一区二区三区涩爱 | 精品欧美亚洲韩国日本久久 | 午夜影院免费看 | 国产AV国片精品有毛 | 国产亚洲精品久久久久久青梅 | 男女超爽视频免费播放 | 人人插97 | 视频免费一区 | 亚洲国产AV天码精品果冻传媒 | 黄色av| 久久国产午夜精品理论片推荐 | 欧美亚洲另类在线观看 | 91精品国产高清一区二区三密臀 | 深夜国产一区二区三区在线看 | 又大又硬又爽免费视频 | 国产欧美一级 | 国产精品无码av无码 | 亚洲精品视频在线观看网站 | 精品欧美亚洲韩国日本久久 | 国产在线一二三四区 | 亚洲日本在线a | 日本真人添下面视频免费 | 国产精品网址在线观看 | 99er久久| 国产成人免费一区二区三区 | 直接观看黄网站免费视频 | 久久久久久久波多野结衣高潮 | 久久久精品国产 | 婷婷久久国产对白刺激五月99 | 黄色在线视频观看 | 久久97超碰 | 丝袜美腿精品国产一区 | 亚洲狠狠婷婷综合久久久久图片 |