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Rabbit Anti-Calcitonin receptor/AP Conjugated antibody (bs-0124R-AP)
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說 明 書: 100ul  
100ul/2980.00元
大包裝/詢價
產品編號 bs-0124R-AP
英文名稱 Rabbit Anti-Calcitonin receptor/AP Conjugated antibody
中文名稱 堿性磷酸酶(AP)標記的降鈣素受體抗體
別    名 Calcitonin receptor precursor; Calcr; CRT; CT R; CTR; CTR1; CALCR_MOUSE; CT-R; CALCR_HUMAN.  
規格價格 100ul/2980元 購買        大包裝/詢價
說 明 書 100ul  
研究領域 腫瘤  免疫學  神經生物學  信號轉導  細胞膜受體  G蛋白偶聯受體  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應 Rat,  (predicted: Mouse, )
產品應用 WB=1:50-200 IHC-P=1:50-200 IHC-F=1:50-200 ICC=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 53kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from mouse Calcitonin receptor
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產品介紹 background:
This gene encodes a high affinity receptor for the peptide hormone calcitonin and belongs to a subfamily of seven transmembrane-spanning G protein-coupled receptors. The encoded protein is involved in maintaining calcium homeostasis and in regulating osteoclast-mediated bone resorption. Polymorphisms in this gene have been associated with variations in bone mineral density and onset of osteoporosis. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2009]

Function:
This is a receptor for calcitonin. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. The calcitonin receptor is thought to couple to the heterotrimeric guanosine triphosphate-binding protein that is sensitive to cholera toxin.

Subunit:
Interacts with GPRASP2.

Subcellular Location:
Cell membrane; Multi-pass membrane protein.

Similarity:
Belongs to the G-protein coupled receptor 2 family.

Database links:

Entrez Gene: 799 Human

Entrez Gene: 12311 Mouse

Entrez Gene: 116506 Rat

Omim: 114131 Human

SwissProt: P30988 Human

SwissProt: Q60755 Mouse

SwissProt: P32214 Rat

Unigene: 489127 Human

Unigene: 4642 Mouse

Unigene: 10062 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

降鈣素受體(Calcitonin receptor,CT-R)是G蛋白偶聯受體,有兩種受體亞型,CT-R可與多種配體結合,如CGRP、Amylin、Am等。CT-R在破骨細胞中含量最高,也存在于腎等多種器官組織內。
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