97久久久精品综合88久久_亚洲国产精品一_久热热国产久热_97操操操_北条麻妃在线免费观看_精品国自产拍天天拍

掃碼關注公眾號           掃碼咨詢技術支持           掃碼咨詢技術服務
  
客服熱線:400-901-9800  客服QQ:4009019800  技術答疑  技術支持  質量反饋  關于我們  聯系我們
性国产se╳o色欲a片欢迎观看,最新合集国产专区,九色91在线
首頁 > 產品中心 > 標記一抗 > 產品信息
Rabbit Anti-Phospho-IRAK1 (Thr209)/AP Conjugated antibody (bs-3193R-AP)
訂購熱線:400-901-9800
訂購郵箱:sales@bioss.com.cn
訂購QQ:  400-901-9800
技術支持:techsupport@bioss.com.cn
說 明 書: 100ul  
100ul/2980.00元
大包裝/詢價
產品編號 bs-3193R-AP
英文名稱 Rabbit Anti-Phospho-IRAK1 (Thr209)/AP Conjugated antibody
中文名稱 堿性磷酸酶(AP)標記的磷酸化白介素-1受體相關激酶1抗體
別    名 IRAK (phospho T209); p-IRAK (phospho T209); IRAK1 (Phospho-Thr209); IRAK1 (Phospho-T209); IRAK1 (p-Thr209); Il1rak; Il1rak; Interleukin 1 receptor associated kinase 1; Interleukin 1 receptor associated kinase 1; Interleukin 1 receptor associated kinase 2; Interleukin-1 receptor-associated kinase 1; IRAK; IRAK-1; IRAK1; IRAK1; IRAK1_HUMAN; IRAK2; IRAK2; mPLK; mPLK; Pelle; Pelle; Pelle homolog; Pelle-like protein kinase; Plpk.  
規格價格 100ul/2980元 購買        大包裝/詢價
說 明 書 100ul  
產品類型 磷酸化抗體 
研究領域 腫瘤  免疫學  細胞凋亡  轉錄調節因子  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應 Human, Rat, 
產品應用 WB=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 78kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthesised phosphopeptide derived from human IRAK1 around the phosphorylation site of Thr209 [RG(p-T)HN]
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產品介紹 background:
This gene encodes the interleukin-1 receptor-associated kinase 1, one of two putative serine/threonine kinases that become associated with the interleukin-1 receptor (IL1R) upon stimulation. This gene is partially responsible for IL1-induced upregulation of the transcription factor NF-kappa B. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Function:
Serine/threonine-protein kinase that plays a critical role in initiating innate immune response against foreign pathogens. Involved in Toll-like receptor (TLR) and IL-1R signaling pathways. Is rapidly recruited by MYD88 to the receptor-signaling complex upon TLR activation. Association with MYD88 leads to IRAK1 phosphorylation by IRAK4 and subsequent autophosphorylation and kinase activation. Phosphorylates E3 ubiquitin ligases Pellino proteins (PELI1, PELI2 and PELI3) to promote pellino-mediated polyubiquitination of IRAK1. Then, the ubiquitin-binding domain of IKBKG/NEMO binds to polyubiquitinated IRAK1 bringing together the IRAK1-MAP3K7/TAK1-TRAF6 complex and the NEMO-IKKA-IKKB complex. In turn, MAP3K7/TAK1 activates IKKs (CHUK/IKKA and IKBKB/IKKB) leading to NF-kappa-B nuclear translocation and activation. Alternatively, phosphorylates TIRAP to promote its ubiquitination and subsequent degradation. Phosphorylates the interferon regulatory factor 7 (IRF7) to induce its activation and translocation to the nucleus, resulting in transcriptional activation of type I IFN genes, which drive the cell in an antiviral state. When sumoylated, translocates to the nucleus and phosphorylates STAT3

Subunit:
Homodimer. Interacts with TOLLIP; this interaction occurs in the cytosol prior to receptor activation. Interacts with MYD88; this interaction recruits IRAK1 to the stimulated receptor complex. Interacts with IL1RL1. Interacts with IRAK1BP1. Associates with TRAF6, PELI1 and IRAK4; this complex recruits MAP3K7/TAK1, TAB1 and TAB2 to mediate NF-kappa-B activation. Interacts (when polyubiquitinated) with IKBKG/NEMO.

Subcellular Location:
Cytoplasm. Nucleus. Note=Translocates to the nucleus when sumoylated.

Tissue Specificity:
Isoform 1 and isoform 2 are ubiquitously expressed in all tissues examined, with isoform 1 being more strongly expressed than isoform 2.

Post-translational modifications:
Following recruitment on the activated receptor complex, phosphorylated on Thr-209, probably by IRAK4, resulting in a conformational change of the kinase domain, allowing further phosphorylations to take place. Thr-387 phosphorylation in the activation loop is required to achieve full enzymatic activity.
Polyubiquitinated after cell stimulation with IL-1-beta by PELI1, PELI2 and PELI3. Polyubiquitination occurs with polyubiquitin chains linked through 'Lys-63'. Ubiquitination promotes interaction with NEMO/IKBKG. Also sumoylated; leading to nuclear translocation.

Similarity:
Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. Pelle subfamily.
Contains 1 death domain.
Contains 1 protein kinase domain.

Database links:

Entrez Gene: 3654 Human

Entrez Gene: 16179 Mouse

Entrez Gene: 363520 Rat

Omim: 300283 Human

SwissProt: P51617 Human

SwissProt: Q62406 Mouse

Unigene: 522819 Human

Unigene: 38241 Mouse

Unigene: 22238 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
版權所有 2004-2026 www.kastlife.cn 北京博奧森生物技術有限公司
通過國際質量管理體系ISO 9001:2015 GB/T 19001-2016    證書編號: 00124Q34771R2M/1100
通過國際醫療器械-質量管理體系ISO 13485:2016 GB/T 42061-2022    證書編號: CQC24QY10047R0M/1100
京ICP備05066980號-1         京公網安備110107000727號
主站蜘蛛池模板: 中文字幕3页 | 国产性xxxx18免费观看视频 | 日韩精品99| 国产一区免费看 | 全免费午夜一级毛片真人 | 亚洲最大天堂网 | 二区三区福利 | 亚洲久悠悠色悠在线播放 | 很黄的网站在线观看 | 国内在线高清免费视频 | 国产精品偷伦小说 | 色很久综合 | 色综合视频一区二区三区44 | 日韩经典在线观看 | 在线观看av网站永久 | 国产精品扒开腿做爽爽爽视频 | 色妞AV永久一区二区国产AV | 欧洲美妇乱人伦视频网站 | 99久久精品免费看国产免费软件 | 一区二区福利 | 国产国产午夜福利视 | 日本高清一二区 | 亚洲欧美日韩在线观看一区二区三区 | 亚洲视频一二区 | 无码专区在线观看韩国 | 无码人妻精品1国产婷婷 | 国产做A爰片毛片A片美国 | 黄色免费在线观看网站 | 精品人妻无码专区在中文字幕 | 久久精品国产一区二区三区四区 | youjizz丰满熟妇中国 | 久久久999国产视频 成人综合久久综合 | 制服丝袜中文字幕无码自拍 | 日韩精品资源二区在线 | 欧美日韩一区免费 | 日本免费三级网站 | 国产一区二区四区在线观看 | 欧美一性一交一A片费看 | 久久久久亚洲a | 一级片黄色一级片 | 少妇一级淫片 |