97久久久精品综合88久久_亚洲国产精品一_久热热国产久热_97操操操_北条麻妃在线免费观看_精品国自产拍天天拍

掃碼關注公眾號           掃碼咨詢技術支持           掃碼咨詢技術服務
  
客服熱線:400-901-9800  客服QQ:4009019800  技術答疑  技術支持  質量反饋  關于我們  聯系我們
日韩人妻精品一区二区三区视频,91美剧在线,国产精品成熟老妇女
首頁 > 產品中心 > 標記一抗 > 產品信息
Rabbit Anti-Phospho-IRF3 (Ser396)/AP Conjugated antibody (bs-3195R-AP)
訂購熱線:400-901-9800
訂購郵箱:sales@bioss.com.cn
訂購QQ:  400-901-9800
技術支持:techsupport@bioss.com.cn
說 明 書: 100ul  
100ul/2980.00元
大包裝/詢價
產品編號 bs-3195R-AP
英文名稱 Rabbit Anti-Phospho-IRF3 (Ser396)/AP Conjugated antibody
中文名稱 堿性磷酸酶(AP)標記的磷酸化干擾素調節因子3
別    名 IRF3 (phospho S396); IRF3 (phospho Ser396); p-IRF3 (Ser396); p-IRF3 (S396); Interferon regulatory factor 3; IRF 3; IRF-3; IRF3; IRF3_HUMAN; MGC94729.  
規格價格 100ul/2980元 購買        大包裝/詢價
說 明 書 100ul  
產品類型 磷酸化抗體 
研究領域 腫瘤  免疫學  信號轉導  細胞凋亡  轉錄調節因子  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應 Human, Rat,  (predicted: Mouse, Dog, Pig, Cow, Sheep, )
產品應用 IHC-P=1:50-200 IHC-F=1:50-200 ICC=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 47kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthesised phosphopeptide derived from human IRF3 around the phosphorylation site of Ser396
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產品介紹 background:
This gene encodes a member of the interferon regulatory transcription factor (IRF) family. The encoded protein is found in an inactive cytoplasmic form that upon serine/threonine phosphorylation forms a complex with CREBBP. This complex translocates to the nucleus and activates the transcription of interferons alpha and beta, as well as other interferon-induced genes. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Nov 2011].

Function:
Mediates interferon-stimulated response element (ISRE) promoter activation. Functions as a molecular switch for antiviral Key transcriptional regulator of type I interferon (IFN)-dependent immune responses and plays a critical role in the innate immune response against DNA and RNA viruses. Regulates the transcription of type I IFN genes (IFN-alpha and IFN-beta) and IFN-stimulated genes (ISG) by binding to an interferon-stimulated response element (ISRE) in their promoters. Acts as a more potent activator of the IFN-beta (IFNB) gene than the IFN-alpha (IFNA) gene and plays a critical role in both the early and late phases of the IFNA/B gene induction. Found in an inactive form in the cytoplasm of uninfected cells and following viral infection, double-stranded RNA (dsRNA), or toll-like receptor (TLR) signaling, becomes phosphorylated by IKBKE and TBK1 kinases. This induces a conformational change, leading to its dimerization and nuclear localization and association with CREB binding protein (CREBBP) to form dsRNA-activated factor 1 (DRAF1), a complex which activates the transcription of the type I IFN and ISG genes. Can activate distinct gene expression programs in macrophages and can induce significant apoptosis in primary macrophages.

Subunit:
Monomer. Homodimer; phosphorylation-induced. Heterodimer with IRF7. Interacts with CREBBP. May interact with MAVS. Interacts with IKBKE and TBK1. Interacts with TICAM1 and TICAM2. Interacts with rotavirus A NSP1 (via C-terminus); this interaction leads to the proteasome-dependent degradation of IRF3. Interacts with RBCK1. Interacts with TRIM21. Interacts with HERC5.

Subcellular Location:
Cytoplasm. Nucleus. Note=Shuttles between cytoplasmic and nuclear compartments, with export being the prevailing effect. When activated, IRF3 interaction with CREBBP prevents its export to the cytoplasm.

Tissue Specificity:
Expressed constitutively in a variety of tissues.

Post-translational modifications:
Constitutively phosphorylated on many serines residues. C-terminal serine/threonine cluster is phosphorylated in response of induction by IKBKE and TBK1. Ser-385 and Ser-386 may be specifically phosphorylated in response to induction. An alternate model propose that the five serine/threonine residues between 396 and 405 are phosphorylated in response to a viral infection. Phosphorylation, and subsequent activation of IRF3 is inhibited by vaccinia virus protein E3.
Ubiquitinated; ubiquitination involves RBCK1 leading to proteasomal degradation. Polyubiquitinated; ubiquitination involves TRIM21 leading to proteasomal degradation.
ISGylated by HERC5 resulting in sustained IRF3 activation and in the inhibition of IRF3 ubiquitination by disrupting PIN1 binding. The phosphorylation state of IRF3 does not alter ISGylation.

Similarity:
Belongs to the IRF family.
Contains 1 IRF tryptophan pentad repeat DNA-binding domain.

Database links:

Entrez Gene: 3661 Human

Entrez Gene: 54131 Mouse

Omim: 603734 Human

SwissProt: Q14653 Human

SwissProt: P70671 Mouse

Unigene: 289052 Human

Unigene: 75254 Human

Unigene: 3960 Mouse



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

干擾素調節因子家族是一大類對干擾素起調控作用的轉錄因子的統稱。 一般認為干擾素調節因子(IRF)通過調節干擾素的表達而行使其抗病毒、應激、免疫調節功能。近年來,研究人員發現IRF在細胞凋亡、細胞周期、細胞分化、腫瘤發生中也起著重要的調節作用。
版權所有 2004-2026 www.kastlife.cn 北京博奧森生物技術有限公司
通過國際質量管理體系ISO 9001:2015 GB/T 19001-2016    證書編號: 00124Q34771R2M/1100
通過國際醫療器械-質量管理體系ISO 13485:2016 GB/T 42061-2022    證書編號: CQC24QY10047R0M/1100
京ICP備05066980號-1         京公網安備110107000727號
主站蜘蛛池模板: 亚洲欧美日韩综合俺去了 | a级一级毛片 | 免费精品视频一区二区 | 亚洲精品久久久久69影院 | 亚洲国产黄色 | 久热精品视频在线观看 | 火影大胸美女被黄网站 | 夜夜调教禁脔欢爱h | 国产AⅤ爽AV久久久久玉浦团 | 色综合视频一区二区三区44 | 亚洲精品久久久久无码精品 | 999久久精品 | 国产成人综合自拍 | 91久久久久国产一区二区 | 欧美18免费视频 | www.狠狠| 日本一区二区三区在线看 | bt天堂在线www中文 | 欧美成人网视频 | 国产激情高中生呻吟视频 | 免费精品视频一区二区 | 无码人妻一区二区免费AV | 国产精品乱码精品久久久 | 中文字幕日韩在线 | 欧美精品二区中文乱码字幕高清 | 久久的色 | 午夜影院啊啊啊 | 亚洲精品久久无码 | 免费性片| 麻豆av一区二区三区久久 | 99在线精品一区二区三区 | 超碰69| 久久综合免费视频影院 | 成人免费在线视频播放 | 精品国产精品久久一区免费式 | 色欲久久久天天天综合影院 | 中文字幕免费久久 | 国产成人精品午夜福利软件 | 久久久久久精品一区二区三区日本 | 日本免费三级网站 | 2022色婷婷综合久久久 |