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Rabbit Anti-HDAC6/BF488 Conjugated antibody (bs-2811R-BF488)
訂購(gòu)熱線:400-901-9800
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說(shuō) 明 書: 100ul  
100ul/2980.00元
大包裝/詢價(jià)
產(chǎn)品編號(hào) bs-2811R-BF488
英文名稱 Rabbit Anti-HDAC6/BF488 Conjugated antibody
中文名稱 BF488標(biāo)記的組蛋白去乙酰化酶6抗體
別    名 HD 6; HD6; HDAC 6; Histone deacetylase 6; HD6; Histone deacetylase 6; JM 21; JM21; KIAA0901; FLJ16239; HDAC6_HUMAN.  
規(guī)格價(jià)格 100ul/2980元 購(gòu)買        大包裝/詢價(jià)
說(shuō) 明 書 100ul  
研究領(lǐng)域 腫瘤  免疫學(xué)  發(fā)育生物學(xué)  信號(hào)轉(zhuǎn)導(dǎo)  細(xì)胞凋亡  轉(zhuǎn)錄調(diào)節(jié)因子  表觀遺傳學(xué)  
抗體來(lái)源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) Human, Rat,  (predicted: Mouse, Cow, Horse, Rabbit, )
產(chǎn)品應(yīng)用 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 134kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human HDAC6
亞    型 IgG
純化方法 affinity purified by Protein A
儲(chǔ) 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產(chǎn)品介紹 background:
Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to class II of the histone deacetylase/acuc/apha family. It contains an internal duplication of two catalytic domains which appear to function independently of each other. This protein possesses histone deacetylase activity and represses transcription. [provided by RefSeq, Jul 2008].

Function:
Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Plays a central role in microtubule-dependent cell motility via deacetylation of tubulin.
In addition to its protein deacetylase activity, plays a key role in the degradation of misfolded proteins: when misfolded proteins are too abundant to be degraded by the chaperone refolding system and the ubiquitin-proteasome, mediates the transport of misfolded proteins to a cytoplasmic juxtanuclear structure called aggresome. Probably acts as an adapter that recognizes polyubiquitinated misfolded proteins and target them to the aggresome, facilitating their clearance by autophagy.

Subunit:
Interacts with CBFA2T3, HDAC11 and SIRT2. Interacts with F-actin. Interacts with BBIP10. Under proteasome impairment conditions, interacts with UBD via its histone deacetylase 1 and UBP-type zinc-finger regions. Interacts with CYLD. Interacts with ZMYND15 (By similarity). Interacts with DDIT3/CHOP.

Subcellular Location:
Nucleus. Cytoplasm. Note=It is mainly cytoplasmic, where it is associated with microtubules.

Post-translational modifications:
Phosphorylated by AURKA.
Ubiquitinated. Its polyubiquitination however does not lead to its degradation.
Sumoylated in vitro.

Similarity:
Belongs to the histone deacetylase family. HD type 2 subfamily.
Contains 1 UBP-type zinc finger.

Database links:

Entrez Gene: 10013 Human

Entrez Gene: 15185 Mouse

Entrez Gene: 84581 Rat

Omim: 300272 Human

SwissProt: Q9UBN7 Human

SwissProt: Q9Z2V5 Mouse

Unigene: 6764 Human

Unigene: 29854 Mouse

Unigene: 13453 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

?組蛋白去乙酰化酶(HDACs)是一組在細(xì)胞染色質(zhì)水平、通過(guò)誘導(dǎo)組蛋白去乙酰化來(lái)調(diào)控包括染色質(zhì)重組、轉(zhuǎn)錄活化或抑制、細(xì)胞周期、細(xì)胞分化及細(xì)胞凋亡等一系列生物學(xué)效應(yīng)的酶,特別是與細(xì)胞活化后的基因轉(zhuǎn)錄表達(dá)調(diào)控有關(guān)。
??? HDAC6是一種比較獨(dú)特的組蛋白去乙酰化酶,含有兩個(gè)功能上相互獨(dú)立的HDAC催化結(jié)構(gòu)域。HDAC6可以去乙酰化組蛋白并抑制相關(guān)基因轉(zhuǎn)錄。
????HDAC6可以和微管(microtuble)結(jié)合,可以去乙酰化tubulin,Hsp90和cortactin等。目前發(fā)現(xiàn)大量的蛋白可以被乙酰化修飾,因此HDAC等乙酰化修飾酶被認(rèn)為在基因轉(zhuǎn)錄調(diào)控、信號(hào)轉(zhuǎn)導(dǎo)、生長(zhǎng)發(fā)育、分化凋亡、代謝性疾病和腫瘤等多種生理病理過(guò)程中發(fā)揮重要作用。HDAC的抑制劑目前被認(rèn)為是很有前景的腫瘤治療藥物。
????內(nèi)源性HDAC6主要定位于細(xì)胞漿,與微管相結(jié)合并且是一個(gè)微管蛋白去乙酰化酶。HDAC6含有一個(gè)鋅指結(jié)構(gòu)域,該結(jié)構(gòu)域可能和泛素化降解的調(diào)節(jié)有關(guān)。HDAC6可以和DHAC11相互作用。
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