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Rabbit Anti-phospho-HDAC6 (Ser22)/PE-Cy5.5 Conjugated antibody (bs-3215R-PE-Cy5.5)
訂購熱線:400-901-9800
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說 明 書: 100ul  
100ul/2980.00元
大包裝/詢價
產品編號 bs-3215R-PE-Cy5.5
英文名稱 Rabbit Anti-phospho-HDAC6 (Ser22)/PE-Cy5.5 Conjugated antibody
中文名稱 PE-Cy5.5標記的磷酸化組蛋白去乙酰化酶6抗體
別    名 HDAC6 (phospho S22); p-HDAC6 (phospho S22); HDAC6 (phospho Ser22); p-HDAC6 (Ser22); HD 6; HD6; HDAC 6; Histone deacetylase 6; HD6; Histone deacetylase 6; JM 21; JM21; KIAA0901; FLJ16239; HDAC6_HUMAN.  
規格價格 100ul/2980元 購買        大包裝/詢價
說 明 書 100ul  
產品類型 磷酸化抗體 
研究領域 腫瘤  免疫學  發育生物學  信號轉導  細胞凋亡  轉錄調節因子  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應 Human, 
產品應用 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 134kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated Synthesised phosphopeptide derived from human HDAC6 around the phosphorylation site of Ser22
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產品介紹 background:
HDAC6 is a member of the class II mammalian histone deacetylases. Human HDAC6 is composed of 1215 amino acid residues. It possesses two separate putative catalytic domains. Both catalytic domains are fully functional HDACs and contribute independently to the overall activity of HDAC6 protein. A very potent NES is present at the amino-terminus of HDAC6, which was found to play an important role in regulating the shuttling of HDAC6 protein between cytoplasm and nucleus. The shuttling process may be a critical regulatory mechanism of HDAC6 function. The expression of HDAC6 is tightly linked to the state of cell differentiation. HDAC6 may participate in coordinating expression of a group of genes involved in the remodelling of chromatin during cell differentiation.

Function:
Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Plays a central role in microtubule-dependent cell motility via deacetylation of tubulin.
In addition to its protein deacetylase activity, plays a key role in the degradation of misfolded proteins: when misfolded proteins are too abundant to be degraded by the chaperone refolding system and the ubiquitin-proteasome, mediates the transport of misfolded proteins to a cytoplasmic juxtanuclear structure called aggresome. Probably acts as an adapter that recognizes polyubiquitinated misfolded proteins and target them to the aggresome, facilitating their clearance by autophagy.

Subunit:
Interacts with CBFA2T3, HDAC11 and SIRT2. Interacts with F-actin. Interacts with BBIP10. Under proteasome impairment conditions, interacts with UBD via its histone deacetylase 1 and UBP-type zinc-finger regions. Interacts with CYLD. Interacts with ZMYND15 (By similarity). Interacts with DDIT3/CHOP.

Subcellular Location:
Nucleus. Cytoplasm. Note=It is mainly cytoplasmic, where it is associated with microtubules.

Post-translational modifications:
Phosphorylated by AURKA.
Ubiquitinated. Its polyubiquitination however does not lead to its degradation.
Sumoylated in vitro.

Similarity:
Belongs to the histone deacetylase family. HD type 2 subfamily.
Contains 1 UBP-type zinc finger.

Database links:

Entrez Gene: 10013 Human

Entrez Gene: 15185 Mouse

Entrez Gene: 84581 Rat

Omim: 300272 Human

SwissProt: Q9UBN7 Human

SwissProt: Q9Z2V5 Mouse

Unigene: 6764 Human

Unigene: 29854 Mouse

Unigene: 13453 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

????HDAC6是一種比較獨特的組蛋白去乙?;?,含有兩個功能上相互獨立的HDAC催化結構域。HDAC6可以去乙酰化組蛋白并抑制相關基因轉錄。
????HDAC6可以和微管(microtuble)結合,可以去乙?;痶ubulin,Hsp90和cortactin等。目前發現大量的蛋白可以被乙?;揎棧虼薍DAC等乙?;揎椕副徽J為在基因轉錄調控、信號轉導、生長發育、分化凋亡、代謝性疾病和腫瘤等多種生理病理過程中發揮重要作用。HDAC的抑制劑目前被認為是很有前景的腫瘤治療藥物。
????內源性HDAC6主要定位于細胞漿,與微管相結合并且是一個微管蛋白去乙酰化酶。HDAC6含有一個鋅指結構域,該結構域可能和泛素化降解的調節有關。HDAC6可以和DHAC11相互作用。
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