97久久久精品综合88久久_亚洲国产精品一_久热热国产久热_97操操操_北条麻妃在线免费观看_精品国自产拍天天拍

掃碼關注公眾號           掃碼咨詢技術支持           掃碼咨詢技術服務
  
客服熱線:400-901-9800  客服QQ:4009019800  技術答疑  技術支持  質量反饋  關于我們  聯系我們
污污内射在线观看一区二区少妇,亚洲一区二区在线观,欧美精品videos另类日本
首頁 > 產品中心 > 標記一抗 > 產品信息
Rabbit Anti-Phospho-MKK3(Ser218) + MKK6(Ser207) /Biotin Conjugated antibody (bs-3274R-Bio)
訂購熱線:400-901-9800
訂購郵箱:sales@bioss.com.cn
訂購QQ:  400-901-9800
技術支持:techsupport@bioss.com.cn
說 明 書: 100ul  
100ul/2980.00元
大包裝/詢價
產品編號 bs-3274R-Bio
英文名稱 Rabbit Anti-Phospho-MKK3(Ser218) + MKK6(Ser207) /Biotin Conjugated antibody
中文名稱 生物素標記的磷酸化絲裂原活化蛋白激酶MKK3/6抗體
別    名 MKK3(Phospho-Ser218); MAP Kinase Kinase 3; Dual specificity mitogen activated protein kinase kinase 3; ERK kinase 3; MAP kinase kinase 3; MAP2K 3; MAPK ERK kinase 3; MAPK kinase 3; MAPKK 3; MAPKK3; MEK 3; MEK3; Mitogen activated protein kinase kinase 3; MKK 3; MKK3; mMKK 3b; mMKK3b; MPK 3; PRKMK 3; PRKMK3; Protein kinase mitogen activated kinase 3; SKK2; zMKK 3; MP2K3_HUMAN; MP2K6_HUMAN  
規格價格 100ul/2980元 購買        大包裝/詢價
說 明 書 100ul  
產品類型 磷酸化抗體 
研究領域 腫瘤  信號轉導  細胞凋亡  生長因子和激素  轉錄調節因子  激酶和磷酸酶  細胞膜受體  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應 Mouse, Rat,  (predicted: Human, Chicken, Dog, Pig, Cow, Horse, Rabbit, )
產品應用 WB=1:50-200 ELISA=1:100-1000 IHC-P=1:50-200 IHC-F=1:50-200 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 39kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthesised phosphopeptide derived from human MKK3 around the phosphorylation site of Ser218
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產品介紹 background:
The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase is activated by mitogenic and environmental stress, and participates in the MAP kinase-mediated signaling cascade. It phosphorylates and thus activates MAPK14/p38-MAPK. This kinase can be activated by insulin, and is necessary for the expression of glucose transporter. Expression of RAS oncogene is found to result in the accumulation of the active form of this kinase, which thus leads to the constitutive activation of MAPK14, and confers oncogenic transformation of primary cells. The inhibition of this kinase is involved in the pathogenesis of Yersina pseudotuberculosis. Multiple alternatively spliced transcript variants that encode distinct isoforms have been reported for this gene.

Function:
Dual specificity kinase. Is activated by cytokines and environmental stress in vivo. Catalyzes the concomitant phosphorylation of a threonine and a tyrosine residue in the MAP kinase p38.

Subunit:
Binds to DYRK1B/MIRK and increases its kinase activity. Part of a complex with MAP3K3, RAC1 and CCM2. Interacts with ARRB1. Interacts with Yersinia yopJ.

Tissue Specificity:
Abundant expression is seen in the skeletal muscle. It is also widely expressed in other tissues.

Post-translational modifications:
Autophosphorylated. Phosphorylation on Ser-218 and Thr-222 by MAP kinase kinase kinases regulates positively the kinase activity. Phosphorylated by TAOK2.
Yersinia yopJ may acetylate Ser/Thr residues, preventing phosphorylation and activation, thus blocking the MAPK signaling pathway.

DISEASE:
Note=Defects in MAP2K3 may be involved in colon cancer.

Similarity:
Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase subfamily.
Contains 1 protein kinase domain.

Database links:

Entrez Gene: 5606 Human

Entrez Gene: 26397 Mouse

Entrez Gene: 303200 Rat

Omim: 602315 Human

SwissProt: P46734 Human

SwissProt: O09110 Mouse

Unigene: 514012 Human

Unigene: 18494 Mouse

Unigene: 100064 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
版權所有 2004-2026 www.kastlife.cn 北京博奧森生物技術有限公司
通過國際質量管理體系ISO 9001:2015 GB/T 19001-2016    證書編號: 00124Q34771R2M/1100
通過國際醫療器械-質量管理體系ISO 13485:2016 GB/T 42061-2022    證書編號: CQC24QY10047R0M/1100
京ICP備05066980號-1         京公網安備110107000727號
主站蜘蛛池模板: 亚洲欧洲一区二区三区在线 | 少妇高潮呻吟在线观看 | 亚洲高清无吗 | 无码免费毛片手机在线 | 国产91免费看 | 久久中文字幕一区二区三区 | 日韩精品视频在线观看视频 | 日本午夜在线观看 | japanese国产乱在线播放 | 免费小视频在线观看 | 超碰91青青国产福利手机看片 | 黑人上司粗大拔不出来 | 黄色片在线免费 | 欧美日韩一级黄 | 最近日本MV字幕免费观看 | 888久久 | 国产大片中文字幕在线观看 | 日韩美女爱爱 | 精品护士一区二区三区 | 高级毛片 | 欧美日本中文 | av狼地址| 免费羞羞视频无遮挡噼啪男男 | 龙珠z免费观看国语版 | 国产精品yjizz视频网 | 91视频在线免费看 | 国产爽视频 | 综合亚洲自拍 | 成人毛片一级 | 特级黄色毛片 | 九一视频国产 | 沦为公交两奶头春药高潮迭起 | 涩涩一区二区 | 国产乱子伦视频一区二区三区 | 日本美女黄网站 | 在线观看黄的网站 | 亚洲国产精品无码一区二区三区 | 高清日韩一区二区 | 日本A级作爱片金瓶双艳 | 免费看的黄色av网站 | 日本免费三片在线播放 |