97久久久精品综合88久久_亚洲国产精品一_久热热国产久热_97操操操_北条麻妃在线免费观看_精品国自产拍天天拍

掃碼關注公眾號           掃碼咨詢技術支持           掃碼咨詢技術服務
  
客服熱線:400-901-9800  客服QQ:4009019800  技術答疑  技術支持  質量反饋  關于我們  聯系我們
亚洲乱码视频,888久久久,国产情侣2020免费视频
首頁 > 產品中心 > 標記一抗 > 產品信息
Rabbit Anti-Phospho-MLK3(Thr277 + Ser281)/AP Conjugated antibody (bs-3280R-AP)
訂購熱線:400-901-9800
訂購郵箱:sales@bioss.com.cn
訂購QQ:  400-901-9800
技術支持:techsupport@bioss.com.cn
說 明 書: 100ul  
100ul/2980.00元
大包裝/詢價
產品編號 bs-3280R-AP
英文名稱 Rabbit Anti-Phospho-MLK3(Thr277 + Ser281)/AP Conjugated antibody
中文名稱 堿性磷酸酶(AP)標記的磷酸化絲氨酸/蘇氨酸蛋白激酶MLK3抗體
別    名 MEKK11; MGC17114; Mitogen-activated protein kinase kinase kinase 11; Mixed lineage kinase 3; Mixed lineage protein kinase 3; Mlk-3; Mlk3; Protein tyrosine kinase PTK1; PTK1; RHOE; SH3 domain containing proline rich kinase; SPRK; Src-homology 3 domain-containing proline-rich kinase; 2610017K16Rik; EC 2.7.11.25; M3K11_HUMAN.  
規格價格 100ul/2980元 購買        大包裝/詢價
說 明 書 100ul  
產品類型 磷酸化抗體 
研究領域 免疫學  神經生物學  信號轉導  細胞凋亡  轉錄調節因子  激酶和磷酸酶  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應 Human, Mouse, Rat,  (predicted: Dog, Pig, Cow, Rabbit, Guinea Pig, )
產品應用 WB=1:50-200 IHC-P=1:50-200 IHC-F=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 93kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthesised phosphopeptide derived from human MLK3 around the phosphorylation site of Thr277/Ser281
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產品介紹 background:
Members of the mixed-lineage kinase (MLK) family (including MLK1, MLK2, MLK3, and dual leucine zipper kinase [DLK]) are serine/threonine protein kinases that are expressed in multiple cell types. MLK3 is activated by phosphorylation in response to stress stimuli (e.g., inflammatory responses, UV, chemical stress) that are coupled to the small GTPase, Cdc42/rac. MLK3 is a multifunctional kinase that plays an essential role in several signaling pathways, including mitogen-activated protein kinase (i.e. activation of JNK and p38), IkappaB/NFkappaB, and p70 S6 kinase. Indeed MLK3 signaling occurs through multiple signaling domains in this protein kinase including (from N- to C-terminal) a glycine-rich domain, Src homology 3 (SH3) domain, a kinase domain, a zipper domain, a Cdc42/rac interactive binding (CRIB) domain and a Pro/Ser/Thr-rich domain. Phosphorylation of MLK3 occurs on multiple residues including threonine 277 and serine 281 within the activation loop of the kinase domain.

Function:
Activates the JUN N-terminal pathway. Required for serum-stimulated cell proliferation and for mitogen and cytokine activation of MAPK14 (p38), MAPK3 (ERK) and MAPK8 (JNK1). Plays a role in mitogen-stimulated phosphorylation and activation of BRAF, but does not phosphorylate BRAF directly. Influences microtubule organization during the cell cycle.

Subunit:
Homodimer; undergoes dimerization during activation.

Subcellular Location:
Cytoplasm, cytoskeleton, centrosome. Note=Location is cell cycle dependent.

Tissue Specificity:
Expressed in a wide variety of normal and neoplastic tissues including fetal lung, liver, heart and kidney, and adult lung, liver, heart, kidney, placenta, skeletal muscle, pancreas and brain.

Post-translational modifications:
Autophosphorylation on serine and threonine residues within the activation loop plays a role in enzyme activation. Thr-277 is likely to be the main autophosphorylation site. Phosphorylation of Ser-555 and Ser-556 is induced by CDC42.

Similarity:
Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.
Contains 1 protein kinase domain.
Contains 1 SH3 domain.

Database links:

Entrez Gene: 4296 Human

Entrez Gene: 26403 Mouse

Omim: 600050 Human

SwissProt: Q16584 Human

SwissProt: Q6P2G4 Human

SwissProt: Q80XI6 Mouse

Unigene: 502872 Human

Unigene: 185026 Mouse



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

MLK3是JNK蛋白上游的重要活化因子,通過直接磷酸化并激活中游MKK4/7蛋白激酶,從而激活JNK應激信號通路。
版權所有 2004-2026 www.kastlife.cn 北京博奧森生物技術有限公司
通過國際質量管理體系ISO 9001:2015 GB/T 19001-2016    證書編號: 00124Q34771R2M/1100
通過國際醫療器械-質量管理體系ISO 13485:2016 GB/T 42061-2022    證書編號: CQC24QY10047R0M/1100
京ICP備05066980號-1         京公網安備110107000727號
主站蜘蛛池模板: 每日更新在线观看AV_手机 | 亚洲日本成人在线观看 | 国产精品一区二区三区视频网站 | 三级毛片视频 | 嫩草院一区二区乱码蜜臀 | 国产激情无码视频在线播放性色 | 日韩视频一区在线观看 | 强壮的公次次弄得我高潮a片日本 | 久爱www人成视频在线观看 | 久久不卡一区 | 黑人精品欧美一区二区蜜桃 | 欧美在线视频免费 | 免费观看一级大片 | 中文字幕一区视频 | 亚洲第一网站男人都懂 | 久久婷av | 香港三级韩国三级日本三级 | 97久久欧美国产亚洲 | 在线看片免费人成视频影院看 | 99久久精 | 国产91精品亚洲一区二区三区 | 日韩精品一区二区三区蜜臀 | 国产精品一区二区三区久久久久 | 欧美性xxxx狂欢老少配 | 欧美成人国产 | 穿透明白衬衫喷奶水的av | 久久国产午夜精品理论片推荐 | 色哟哟网站入口在线观看 | 中文在线综合 | AV中文无码乱人伦在线观看 | 91蜜臀精品国产自偷在线 | 日日嗨av一区二区三区四区 | 日韩在线 | 国产一区二区成人久久免费影院 | 青青视频免费在线 | 国产区精品一区二区不卡中文 | free性欧美1819护士 | 男人被口爽还是啪啪爽 | 色国产精品一区在线观看 | 亚洲欧洲偷自拍图片区 | 久久婷婷五月综合色丁香 |