97久久久精品综合88久久_亚洲国产精品一_久热热国产久热_97操操操_北条麻妃在线免费观看_精品国自产拍天天拍

掃碼關注公眾號           掃碼咨詢技術支持           掃碼咨詢技術服務
  
客服熱線:400-901-9800  客服QQ:4009019800  技術答疑  技術支持  質量反饋  關于我們  聯(lián)系我們
国产九九在线,亚洲精品久久国产精品37P,久久欧美日韩精品一区二区
首頁 > 產品中心 > 標記一抗 > 產品信息
Rabbit Anti-PCGF4/BMI1/PE-Cy5.5 Conjugated antibody (bs-2999R-PE-Cy5.5)
訂購熱線:400-901-9800
訂購郵箱:sales@bioss.com.cn
訂購QQ:  400-901-9800
技術支持:techsupport@bioss.com.cn
說 明 書: 100ul  
100ul/2980.00元
大包裝/詢價
產品編號 bs-2999R-PE-Cy5.5
英文名稱 Rabbit Anti-PCGF4/BMI1/PE-Cy5.5 Conjugated antibody
中文名稱 PE-Cy5.5標記的組蛋白相關Bmi1抗體
別    名 B lymphoma Mo MLV insertion region; Bmi 1; BMI-1; MGC12685; Murine leukemia viral (bmi 1) oncogene homolog; Oncogene BMI 1; PCGF 4; PCGF4; Polycomb complex protein BMI 1; Polycomb complex protein BMI-1; Polycomb group ring finger 4; Polycomb group RING finger protein 4; RING finger protein 51; BMI1; RNF51; RAD18; BMI1_HUMAN.  
規(guī)格價格 100ul/2980元 購買        大包裝/詢價
說 明 書 100ul  
研究領域 腫瘤  細胞生物  信號轉導  干細胞  細胞凋亡  轉錄調節(jié)因子  激酶和磷酸酶  表觀遺傳學  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應 Human,  (predicted: Mouse, Rat, Chicken, Dog, Cow, Rabbit, )
產品應用 Flow-Cyt=1:50-200 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 37kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human Bmi1/PCGF4
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產品介紹 background:
The Bmi1 oncogene induces telomerase activity and immortalizes human mammary epithelial cells. Bmi1 extends the replicative life span of human fibroblasts by suppressing the p16-dependent senescence pathway.
Polycomb group (PcG) genes are involved in the maintenance of cellular memory through epigenetic chromatin modifications. Recent studies have implicated a role for PcG genes in the self-renewal of hematopoietic stem cells (HSCs), a process in which cellular memory is maintained through cell division. Among the PcG genes, Bmi1 plays a central role in the inheritance of stemness, and its forced expression promotes HSC self-renewal. These findings highlight the importance of epigenetic regulation in HSC self-renewal and identify PcG genes as potential targets for therapeutic HSC manipulation. Involved in maintaining the transcriptionally repressive state of genes. Modifies chromatin, rendering it heritably changed in its expressibility.

Function:
Component of the Polycomb group (PcG) multiprotein PRC1 complex, a complex required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. In the PRC1 complex, it is required to stimulate the E3 ubiquitin-protein ligase activity of RNF2/RING2.

Subcellular Location:
Nucleus. Cytoplasm.

Post-translational modifications:
Monoubiquitinated. May be polyubiquitinated; which does not lead to proteasomal degradation.

Similarity:
Contains 1 RING-type zinc finger.

Database links:

Entrez Gene: 100532731 Human

Entrez Gene: 648 Human

Entrez Gene: 12151 Mouse

Entrez Gene: 307151 Rat

Omim: 164831 Human

SwissProt: P35226 Human

SwissProt: P25916 Mouse

Unigene: 380403 Human

Unigene: 289584 Mouse



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
版權所有 2004-2026 www.kastlife.cn 北京博奧森生物技術有限公司
通過國際質量管理體系ISO 9001:2015 GB/T 19001-2016    證書編號: 00124Q34771R2M/1100
通過國際醫(yī)療器械-質量管理體系ISO 13485:2016 GB/T 42061-2022    證書編號: CQC24QY10047R0M/1100
京ICP備05066980號-1         京公網安備110107000727號
主站蜘蛛池模板: 蜜臀亚洲AV无码精品国产午夜. | 中文字幕免费久久 | 99在线国内在线视频22 | 国产精品国产三级国产av品爱网 | 亚洲精品中国国产嫩草影院美女 | 日本一区二区福利视频 | 真实国产乱子伦精品视频 | 日本男人天堂 | 日本熟妇另类视频在线播放 | 国产精品免费视频一区二区 | 毛片免费毛片一级jjj毛片 | 日韩美女福利视频 | 青青草91久久久久久久久 | 少妇高潮av久久久久久 | 亚洲一区二区制服在线 | 噜噜爽av99 | 亚洲av极品无码专区亚洲av | 国产丝袜一区视频在线观看 | 青青草视频精品 | 国产精品69久久久久孕妇欧美 | 无码国产69精品久久久孕妇 | av免费网站在线 | 高清国产一区二区 | 人妻系列无码专区久久五月天 | 视频精品二区 | 欧美xvideosexo另类 | 国产美女精品福利一区二区 | 裸体午夜一级视频 | 97日韩在线| 久久国产精品久久久 | 91精品片| 日本最黄视频 | 国产福利一区二区三区在线视频 | 自拍私拍网友真实视频 | free性欧美1819hd| 放荡老师张开双腿任我玩 | 亚洲看黄 | 年轻富婆私密推油到高潮 | 亚洲成成熟女人专区 | 91国产一区二区 | 日本黄页网站免费大全1688 |