97久久久精品综合88久久_亚洲国产精品一_久热热国产久热_97操操操_北条麻妃在线免费观看_精品国自产拍天天拍

掃碼關注公眾號           掃碼咨詢技術支持           掃碼咨詢技術服務
  
客服熱線:400-901-9800  客服QQ:4009019800  技術答疑  技術支持  質量反饋  關于我們  聯系我們
网站黄色av,亚洲精品无码久久久久AV老牛,五月天堂网
首頁 > 產品中心 > 標記一抗 > 產品信息
Rabbit Anti-Phospho-CDC42 (Ser71)/RBITC Conjugated antibody (bs-3369R-RBITC)
訂購熱線:400-901-9800
訂購郵箱:sales@bioss.com.cn
訂購QQ:  400-901-9800
技術支持:techsupport@bioss.com.cn
說 明 書: 100ul  
100ul/2980.00元
大包裝/詢價
產品編號 bs-3369R-RBITC
英文名稱 Rabbit Anti-Phospho-CDC42 (Ser71)/RBITC Conjugated antibody
中文名稱 羅丹明(RBITC)標記的磷酸化細胞分化周期CDC42蛋白抗體
別    名 CDC 42; CDC42Hs; Cell division control protein 42 homolog; Cell division cycle 42; Cell division cycle 42 isoform 1; Cell division cycle 42 isoform 2; dJ224A6.1.1; dJ224A6.1.2; G25K; G25K GTP binding protein; Growth regulating protein; GTP binding protein 25kD; Small GTP binding protein CDC42; CDC42_HUMAN.   
規格價格 100ul/2980元 購買        大包裝/詢價
說 明 書 100ul  
產品類型 磷酸化抗體 
研究領域 腫瘤  細胞生物  免疫學  信號轉導  細胞周期蛋白  轉錄調節因子  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應 (predicted: Human, Mouse, Rat, Dog, Sheep, )
產品應用 ICC=1:50-200 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 21kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated Synthesised phosphopeptide derived from human CDC42 around the phosphorylation site of Ser71
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產品介紹 background:
The protein encoded by this gene is a small GTPase of the Rho-subfamily, which regulates signaling pathways that control diverse cellular functions including cell morphology, migration, endocytosis and cell cycle progression. This protein is highly similar to Saccharomyces cerevisiae Cdc 42, and is able to complement the yeast cdc42-1 mutant. The product of oncogene Dbl was reported to specifically catalyze the dissociation of GDP from this protein. This protein could regulate actin polymerization through its direct binding to Neural Wiskott-Aldrich syndrome protein (N-WASP), which subsequently activates Arp2/3 complex. Alternative splicing of this gene results in multiple transcript variants. Pseudogenes of this gene have been identified on chromosomes 3, 4, 5, 7, 8 and 20. [provided by RefSeq, Apr 2013].

Function:
Plasma membrane-associated small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses. Involved in epithelial cell polarization processes. Regulates the bipolar attachment of spindle microtubules to kinetochores before chromosome congression in metaphase. Plays a role in the extension and maintenance of the formation of thin, actin-rich surface projections called filopodia. Mediates CDC42-dependent cell migration.

Subunit:
The GTP-bound form interacts with CCPG1. Interacts with CDC42EP1, CDC42EP2, CDC42EP3, CDC42EP4, CDC42EP5, CDC42SE1, CDC42SE2, PARD6A, PARD6B and PARD6G (in a GTP-dependent manner). Interacts with activated CSPG4 and with BAIAP2. Interacts with Zizimin1/DOCK9 and Zizimin2/DOCK11, which activate it by exchanging GDP for GTP. Interacts with NET1 and ARHGAP33/TCGAP. Part of a complex with PARD3, PARD6A or PARD6B and PRKCI or PRKCZ. Interacts with USP6. May interact with ARHGEF16; responsible for the activation of CDC42 by the viral protein HPV16 E6. Interacts with NEK6. Part of a collagen stimulated complex involved in cell migration composed of CDC42, CRK, TNK2 and BCAR1/p130cas.

Subcellular Location:
Cell membrane; Lipid-anchor; Cytoplasmic side (Potential). Cytoplasm, cytoskeleton, centrosome. Cytoplasm, cytoskeleton, spindle. Midbody.

Post-translational modifications:
AMPylation at Tyr-32 and Thr-35 are mediated by bacterial enzymes in case of infection by H.somnus and V.parahaemolyticus, respectively. AMPylation occurs in the effector region and leads to inactivation of the GTPase activity by preventing the interaction with downstream effectors, thereby inhibiting actin assembly in infected cells. It is unclear whether some human enzyme mediates AMPylation; FICD has such ability in vitro but additional experiments remain to be done to confirm results in vivo.

Similarity:
Belongs to the small GTPase superfamily. Rho family. CDC42 subfamily.

Database links:

Entrez Gene: 998 Human

Entrez Gene: 12540 Mouse

Entrez Gene: 64465 Rat

Omim: 116952 Human

SwissProt: P60953 Human

SwissProt: P60766 Mouse

SwissProt: Q8CFN2 Rat

Unigene: 467637 Human

Unigene: 1022 Mouse

Unigene: 447553 Mouse

Unigene: 60067 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

Cdc42,是細胞骨架和細胞極化的重要調節蛋白,在減數分裂和卵母細胞成熟過程中有重要的作用,尤其在細胞分化,遷移過程中起到一定的作用,目前在腫瘤研究中得到了重視。
版權所有 2004-2026 www.kastlife.cn 北京博奧森生物技術有限公司
通過國際質量管理體系ISO 9001:2015 GB/T 19001-2016    證書編號: 00124Q34771R2M/1100
通過國際醫療器械-質量管理體系ISO 13485:2016 GB/T 42061-2022    證書編號: CQC24QY10047R0M/1100
京ICP備05066980號-1         京公網安備110107000727號
主站蜘蛛池模板: 免费黄网站欧美 | 黑人巨大两根一起挤进交换 | 久久综合九色综合97网 | 人妻一本久道久久综合久久鬼色 | 亚洲AV成人精品网站在线播放 | 国产精品自在在线免费 | 欧美成人免费全部观看天天性色 | 92国产精品偷窥熟女精品视频 | 性xxxx18免费观看视频软件 | 午夜三级A三级三点窝 | A级日本乱理伦片免费入口 四虎精品免费 | 青青草视频在线观 | 国语对白乱子 | 夜夜澡人摸人人添人人看 | 成人亚洲A片V一区二区三区色欲 | 日本hdxxxx少妇1819 | 国产精品扒开腿做爽爽爽A片唱戏 | 精品国产欧美日韩不卡在线观看 | 国产粉嫩美女无套被中出 | 亚洲第一网站 | 日韩人妻无码AV一区二区三区 | 亚洲区色情区激情区小说色情书 | 韩日中文字幕 | 亚洲日本乱码一区二区三区 | 一夲道av无码无卡免费 | 农田丰满艳肉妇hd | av免费在线播放网址 | 日韩av中文字幕第一页 | 亚洲国产精品无码一线岛国 | 边添小泬边狠狠躁视频 | 96超碰在线 | 精品人妻无码专区在中文字幕 | 国产第一页福利影院 | 一区二区观看 | 精品欧美一区二区中文字幕视频 | 欧美日韩在线视频 | 国产精品久久久久无码 | 99在线精品视频观看免费 | 日韩欧美人妻一区二区三区 | 亚洲老司机在线 | 夜夜爽夜夜叫夜夜高潮 |