97久久久精品综合88久久_亚洲国产精品一_久热热国产久热_97操操操_北条麻妃在线免费观看_精品国自产拍天天拍

掃碼關注公眾號           掃碼咨詢技術支持           掃碼咨詢技術服務
  
客服熱線:400-901-9800  客服QQ:4009019800  技術答疑  技術支持  質量反饋  關于我們  聯系我們
天天干天天添,少妇做爰喷水高潮呻吟A片免费 ,夜夜草网
首頁 > 產品中心 > 標記一抗 > 產品信息
Rabbit Anti-WNK1/BF350 Conjugated antibody (bs-3604R-BF350)
訂購熱線:400-901-9800
訂購郵箱:sales@bioss.com.cn
訂購QQ:  400-901-9800
技術支持:techsupport@bioss.com.cn
說 明 書: 100ul  
100ul/2980.00元
大包裝/詢價
產品編號 bs-3604R-BF350
英文名稱 Rabbit Anti-WNK1/BF350 Conjugated antibody
中文名稱 BF350標記的賴氨酸缺陷型蛋白激酶1抗體
別    名 Erythrocyte 65 kDa protein; HSAN2; HSN2; hWNK1; KDP; KIAA0344; Kinase deficient protein; MGC163339; MGC163341; p65; PRKWNK1; Prostate derived sterile 20 like kinase; Protein kinase lysine deficient 1; Protein kinase lysine-deficient 1; Protein kinase with no lysine 1; PSK; Serine/threonine protein kinase WNK1; Serine/threonine-protein kinase WNK1; With no K; WNK lysine deficient protein kinase 1; WNK1; WNK1_HUMAN.  
規格價格 100ul/2980元 購買        大包裝/詢價
說 明 書 100ul  
研究領域 腫瘤  細胞生物  免疫學  信號轉導  細胞凋亡  轉錄調節因子  通道蛋白  轉運蛋白  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應 Rat,  (predicted: Human, Mouse, Dog, Pig, Cow, Horse, Rabbit, )
產品應用 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 251kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human WNK1
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產品介紹 background:
WNK1 controls sodium and chloride ion transport by inhibiting the activity of WNK4, potentially by either phosphorylating the kinase or via an interaction between WNK4 and the autoinhibitory domain of WNK1. WNK4 regulates the activity of the thiazide sensitive Na/Cl cotransporter, SLC12A3, by phosphorylation. WNK1 may also play a role in actin cytoskeletal reorganization.


Function:
Serine/threonine kinase which plays an important role in the regulation of electrolyte homeostasis, cell signaling, survival, and proliferation. Acts as an activator and inhibitor of sodium-coupled chloride cotransporters and potassium-coupled chloride cotransporters respectively. Activates SCNN1A, SCNN1B, SCNN1D and SGK1. Controls sodium and chloride ion transport by inhibiting the activity of WNK4, by either phosphorylating the kinase or via an interaction between WNK4 and the autoinhibitory domain of WNK1. WNK4 regulates the activity of the thiazide-sensitive Na-Cl cotransporter, SLC12A3, by phosphorylation. WNK1 may also play a role in actin cytoskeletal reorganization. Phosphorylates NEDD4L (By similarity).

Subunit:
Interacts with SYT2 (By similarity). Interacts with WNK3 and WNK4 (By similarity).

Subcellular Location:
Cytoplasm.

Tissue Specificity:
Widely expressed, with highest levels observed in the testis, heart, kidney and skeletal muscle. Isoform 3 is kidney-specific.

Post-translational modifications:
O-glycosylated.
Phosphorylated upon DNA damage, probably by ATM or ATR.

DISEASE:
Defects in WNK1 are a cause of pseudohypoaldosteronism type 2C (PHA2C) [MIM:614492]. An autosomal dominant disease characterized by severe hypertension, hyperkalemia, hyperchloremia, mild hyperchloremic metabolic acidosis in some cases, and correction of physiologic abnormalities by thiazide diuretics.
Defects in WNK1 are a cause of hereditary sensory and autonomic neuropathy type 2A (HSAN2A) [MIM:201300]. A form of hereditary sensory and autonomic neuropathy, a genetically and clinically heterogeneous group of disorders characterized by degeneration of dorsal root and autonomic ganglion cells, and by sensory and/or autonomic abnormalities. HSAN2A is an autosomal recessive disorder characterized by impairment of pain, temperature and touch sensation, onset of symptoms in infancy or early childhood, occurrence of distal extremity pathologies (paronychia, whitlows, ulcers, and Charcot joints), frequent amputations, sensory loss that affects all modalities of sensation (lower and upper limbs and perhaps the trunk as well), absence or diminution of tendon reflexes (usually in all limbs), minimal autonomic dysfunction, absence of sensory nerve action potentials, and virtual absence of myelinated fibers with decreased numbers of unmyelinated fibers in sural nerves.

Similarity:
Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. WNK subfamily.
Contains 1 protein kinase domain.

Database links:

Entrez Gene: 65125 Human

Entrez Gene: 100503989 Mouse

Entrez Gene: 232341 Mouse

Entrez Gene: 116477 Rat

Omim: 605232 Human

SwissProt: Q9H4A3 Human

SwissProt: P83741 Mouse

SwissProt: Q9JIH7 Rat

Unigene: 726723 Human

Unigene: 728846 Human

Unigene: 333349 Mouse

Unigene: 484782 Mouse

Unigene: 27409 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

Defects in WNK1 are a cause of pseudohypoaldosteronism type II (PHAII), an autosomal dominant disease characterized by severe hypertension, hyperkalemia, and sensitivity to thiazide diuretics which may result from a chloride shunt in the renal distal nephron.
版權所有 2004-2026 www.kastlife.cn 北京博奧森生物技術有限公司
通過國際質量管理體系ISO 9001:2015 GB/T 19001-2016    證書編號: 00124Q34771R2M/1100
通過國際醫療器械-質量管理體系ISO 13485:2016 GB/T 42061-2022    證書編號: CQC24QY10047R0M/1100
京ICP備05066980號-1         京公網安備110107000727號
主站蜘蛛池模板: 性屋娱乐wwwsex5me | 亚洲AV永久无码精品三区在线4 | 色婷婷av一区二区三区久久 | 一区二区三区四区五区中文字幕 | 亚洲久av| 日本一区二区免费高清视频 | 无码人妻一区二区免费AV | 中文字幕日本 | 精品国产乱码91久久久久久网站 | 91在线免费看 | 成人午夜看片网址 | 极品少妇粉嫩小泬v片可看 99热婷婷 | 国产A∨天天免费观看美女 亚洲精品7777 | 国产麻豆 | 久久久久久精品一区二区三区日本 | 亚洲日韩亚洲另类激情文学一 | 中文久久 | 女人高潮一级一片 | 136fldh导航福利微拍 | 成人性生交大片100部 | a4yy私人毛片 | 一区二区视频免费在线观看 | 国产欧美日韩亚洲精品区 | 91亚洲区| 亚洲国产导航 | 性色aⅤ极品无码专区亚洲 成人水多啪啪片 | 91精品国产精品 | 精品国产一区二区三区久久久久 | JIZZ成熟丰满韩国女人少妇 | 亚洲午夜精品久久久久久高潮 | 久久久久久国产精品免费免费狐狸 | 九九视频免费观看视频精品 | 香蕉国产9 | 69精品无码一区二区 | 强壮公弄得小薇高潮 | 男人操女人逼免费视频 | 日本一卡精品视频免费 | av第一福利网站 | 天天操夜夜拍 | 日本黄色五级片 | 99久久免费只有精品国产高潮 |