97久久久精品综合88久久_亚洲国产精品一_久热热国产久热_97操操操_北条麻妃在线免费观看_精品国自产拍天天拍

掃碼關(guān)注公眾號           掃碼咨詢技術(shù)支持           掃碼咨詢技術(shù)服務(wù)
  
客服熱線:400-901-9800  客服QQ:4009019800  技術(shù)答疑  技術(shù)支持  質(zhì)量反饋  關(guān)于我們  聯(lián)系我們
亚洲另类精品国产一级欧美忘忧草,无码国产偷倩在线播放老年人,国产精品视频三区
Rabbit Anti-Phospho-p73(Tyr99)/AP Conjugated antibody (bs-3717R-AP)
訂購熱線:400-901-9800
訂購郵箱:sales@bioss.com.cn
訂購QQ:  400-901-9800
技術(shù)支持:techsupport@bioss.com.cn
說 明 書: 100ul  
100ul/2980.00元
大包裝/詢價
產(chǎn)品編號 bs-3717R-AP
英文名稱 Rabbit Anti-Phospho-p73(Tyr99)/AP Conjugated antibody
中文名稱 堿性磷酸酶(AP)標(biāo)記的磷酸化P73腫瘤抑制基因抗體
別    名 p73(Phospho-Tyr99); p73 (phospho Y99); p-p73 (phospho Y99);TP73(phospho Y99); p53 like transcription factor; p53 Related Protein; p73; TP 73; TP73; Tumor Protein p73; P73_HUMAN.  
規(guī)格價格 100ul/2980元 購買        大包裝/詢價
說 明 書 100ul  
產(chǎn)品類型 磷酸化抗體 
研究領(lǐng)域 腫瘤  免疫學(xué)  信號轉(zhuǎn)導(dǎo)  細(xì)胞凋亡  轉(zhuǎn)錄調(diào)節(jié)因子  激酶和磷酸酶  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) Human,  (predicted: Mouse, Rat, )
產(chǎn)品應(yīng)用 WB=1:50-200 IHC-P=1:50-200 IHC-F=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 70kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated Synthesised phosphopeptide derived from human p73 around the phosphorylation site of Tyr99 [SP(p-Y)AQ]
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產(chǎn)品介紹 background:
P73 protein is a structural and functional homologue of p53, a tumor suppressor gene. In this study, The p73 protein, p19ras, by the yeast two-hybrid screening method. Alternative splicing of the proto-oncogene H-ras pre-mRNA has led to two distinct transcripts, Ras proteins are known to be small membrane-localized guanine nucleotide-binding proteins. However, unlike other Ras proteins, p19ras is localized in the nucleus and the cytosol and its interaction with P73 protein occurred exclusively in the nucleus. Oncogenic MDM2 (mouse double minutes 2) is a known repressor of p73 transcriptional activity. In this study, when p19ras was bound to MDM2, it further inhibited the association of MDM2 to the p73 protein. Therefore, this study presents a novel pathway of Ras signaling that occurs in the nucleus, involving p19ras and p73.

Function:
Participates in the apoptotic response to DNA damage. Isoforms containing the transactivation domain are pro-apoptotic, isoforms lacking the domain are anti-apoptotic and block the function of p53 and transactivating p73 isoforms. May be a tumor suppressor protein. [COFACTOR] Binds 1 zinc ion per subunit

Subunit:
Found in a complex with p53/TP53 and CABLES1. The C-terminal oligomerization domain binds to the ABL1 tyrosine kinase SH3 domain. Interacts with HECW2. Isoform Beta interacts homotypically and with p53/TP53, whereas isoform Alpha does not. Isoform Gamma interacts homotypically and with all p73 isoforms. Isoform Delta interacts with isoform Gamma, isoform Alpha, and homotypically. Isoforms Alpha and Beta interact with HIPK2. Isoform Alpha interacts with RANBP9. Isoform Beta interacts with WWOX. Interacts (via SAM domain) with FBXO45 (via B30.2/SPRY domain). Interacts with YAP1 (phosphorylated form). Interacts with HCK (via SH3 domain); this inhibits TP73 activity and degradation.

Subcellular Location:
Nucleus. Cytoplasm. Note=Accumulates in the nucleus in response to DNA damage.

Tissue Specificity:
Expressed in striatal neurons of patients with Huntington disease (at protein level). Brain, kidney, placenta, colon, heart, liver, spleen, skeletal muscle, prostate, thymus and pancreas. Highly expressed in fetal tissue.

Post-translational modifications:
Isoform alpha (but not isoform beta) is sumoylated on Lys-627, which potentiates proteasomal degradation but does not affect transcriptional activity. Phosphorylation by PLK1 and PLK3 inhibits the transcription regulator activity and pro-apoptotic function.
Higher levels of phosphorylation seen in the brain from patients with Huntington disease.
Polyubiquitinated by RCHY1/PIRH2; leading to its degradation by the proteasome.

Similarity:
Belongs to the p53 family.
Contains 1 SAM (sterile alpha motif) domain.

Database links:

Entrez Gene: 7161 Human

Entrez Gene: 22062 Mouse

Entrez Gene: 362675 Rat

Omim: 601990 Human

SwissProt: O15350 Human

SwissProt: Q9JJP2 Mouse

Unigene: 697294 Human

Unigene: 706990 Human

Unigene: 78015 Mouse



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

P73是p53基因家族的第一個成員p53基因是一個經(jīng)典的抑癌基因,與p53在結(jié)構(gòu)和功能方面具有很高的相似性。
版權(quán)所有 2004-2026 www.kastlife.cn 北京博奧森生物技術(shù)有限公司
通過國際質(zhì)量管理體系ISO 9001:2015 GB/T 19001-2016    證書編號: 00124Q34771R2M/1100
通過國際醫(yī)療器械-質(zhì)量管理體系ISO 13485:2016 GB/T 42061-2022    證書編號: CQC24QY10047R0M/1100
京ICP備05066980號-1         京公網(wǎng)安備110107000727號
主站蜘蛛池模板: 伊人狠狠 | 成人av在线大片 | 蜜臀av免费一区二区三区水牛 | 国产一区免费看 | 被两个两个黑人吃奶4P | 国产情侣A片A毛片手机在线 | 日日躁夜夜躁人人揉av五月天 | 老司机深夜福利在线观看 | 精品成人毛片一区二区 | 亚洲欧美日韩国产专区一区 | 亚洲黄色免费观看 | 天堂网www天堂在线资源库 | 午夜短视频 | 香港三级精品三级在线专区 | 乱色国内精品视频在线 | 99ri国产精品 | 中文字幕在线视频日本 | 中文日产幕无线码一区2023 | 最新中文字幕一区二区三区 | 黄色一级片免费看 | 又黄又粗暴的120秒免费GIF视频 | 久久久久久久98 | 国产日韩AV免费无码一区二区三区 | 久草精品在线观看 | 在线高潮 | 黄色一级在线视频 | 亚洲综合另类小说色区 | 国产精品免费久久久久久久久久中文 | 爆乳无码中文字幕在线观看 | 成年人在线免费看的惊悚动作片 | 高清视频在线观看 | 国产福利在线观看91精品 | 飘雪影院免费版在线观看视频 | 91精品国产高清一区二区三密臀 | 香蕉视频导航 | 欧美噜噜久久久xxx 日韩av一区二区三区四区 | 国产99久9在线视频 日本无人区码suv | 影音先锋男人站 | 亚洲欧美日韩在线观看一区二区三区 | gogo大胆无码免费视频列表 | 国产二区久久 |