97久久久精品综合88久久_亚洲国产精品一_久热热国产久热_97操操操_北条麻妃在线免费观看_精品国自产拍天天拍

掃碼關注公眾號           掃碼咨詢技術支持           掃碼咨詢技術服務
  
客服熱線:400-901-9800  客服QQ:4009019800  技術答疑  技術支持  質量反饋  關于我們  聯系我們
日本成人动漫在线,日韩福利二区,97SE狠狠狠狠狼鲁亚洲综合色
首頁 > 產品中心 > 標記一抗 > 產品信息
Rabbit Anti-Phospho-p73(Tyr99)/Cy3 Conjugated antibody (bs-3717R-Cy3)
訂購熱線:400-901-9800
訂購郵箱:sales@bioss.com.cn
訂購QQ:  400-901-9800
技術支持:techsupport@bioss.com.cn
說 明 書: 100ul  
100ul/2980.00元
大包裝/詢價
產品編號 bs-3717R-Cy3
英文名稱 Rabbit Anti-Phospho-p73(Tyr99)/Cy3 Conjugated antibody
中文名稱 Cy3標記的磷酸化P73腫瘤抑制基因抗體
別    名 p73(Phospho-Tyr99); p73 (phospho Y99); p-p73 (phospho Y99);TP73(phospho Y99); p53 like transcription factor; p53 Related Protein; p73; TP 73; TP73; Tumor Protein p73; P73_HUMAN.  
規格價格 100ul/2980元 購買        大包裝/詢價
說 明 書 100ul  
產品類型 磷酸化抗體 
研究領域 腫瘤  免疫學  信號轉導  細胞凋亡  轉錄調節因子  激酶和磷酸酶  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應 Human,  (predicted: Mouse, Rat, )
產品應用 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 70kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated Synthesised phosphopeptide derived from human p73 around the phosphorylation site of Tyr99 [SP(p-Y)AQ]
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產品介紹 background:
P73 protein is a structural and functional homologue of p53, a tumor suppressor gene. In this study, The p73 protein, p19ras, by the yeast two-hybrid screening method. Alternative splicing of the proto-oncogene H-ras pre-mRNA has led to two distinct transcripts, Ras proteins are known to be small membrane-localized guanine nucleotide-binding proteins. However, unlike other Ras proteins, p19ras is localized in the nucleus and the cytosol and its interaction with P73 protein occurred exclusively in the nucleus. Oncogenic MDM2 (mouse double minutes 2) is a known repressor of p73 transcriptional activity. In this study, when p19ras was bound to MDM2, it further inhibited the association of MDM2 to the p73 protein. Therefore, this study presents a novel pathway of Ras signaling that occurs in the nucleus, involving p19ras and p73.

Function:
Participates in the apoptotic response to DNA damage. Isoforms containing the transactivation domain are pro-apoptotic, isoforms lacking the domain are anti-apoptotic and block the function of p53 and transactivating p73 isoforms. May be a tumor suppressor protein. [COFACTOR] Binds 1 zinc ion per subunit

Subunit:
Found in a complex with p53/TP53 and CABLES1. The C-terminal oligomerization domain binds to the ABL1 tyrosine kinase SH3 domain. Interacts with HECW2. Isoform Beta interacts homotypically and with p53/TP53, whereas isoform Alpha does not. Isoform Gamma interacts homotypically and with all p73 isoforms. Isoform Delta interacts with isoform Gamma, isoform Alpha, and homotypically. Isoforms Alpha and Beta interact with HIPK2. Isoform Alpha interacts with RANBP9. Isoform Beta interacts with WWOX. Interacts (via SAM domain) with FBXO45 (via B30.2/SPRY domain). Interacts with YAP1 (phosphorylated form). Interacts with HCK (via SH3 domain); this inhibits TP73 activity and degradation.

Subcellular Location:
Nucleus. Cytoplasm. Note=Accumulates in the nucleus in response to DNA damage.

Tissue Specificity:
Expressed in striatal neurons of patients with Huntington disease (at protein level). Brain, kidney, placenta, colon, heart, liver, spleen, skeletal muscle, prostate, thymus and pancreas. Highly expressed in fetal tissue.

Post-translational modifications:
Isoform alpha (but not isoform beta) is sumoylated on Lys-627, which potentiates proteasomal degradation but does not affect transcriptional activity. Phosphorylation by PLK1 and PLK3 inhibits the transcription regulator activity and pro-apoptotic function.
Higher levels of phosphorylation seen in the brain from patients with Huntington disease.
Polyubiquitinated by RCHY1/PIRH2; leading to its degradation by the proteasome.

Similarity:
Belongs to the p53 family.
Contains 1 SAM (sterile alpha motif) domain.

Database links:

Entrez Gene: 7161 Human

Entrez Gene: 22062 Mouse

Entrez Gene: 362675 Rat

Omim: 601990 Human

SwissProt: O15350 Human

SwissProt: Q9JJP2 Mouse

Unigene: 697294 Human

Unigene: 706990 Human

Unigene: 78015 Mouse



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

P73是p53基因家族的第一個成員p53基因是一個經典的抑癌基因,與p53在結構和功能方面具有很高的相似性。
版權所有 2004-2026 www.kastlife.cn 北京博奧森生物技術有限公司
通過國際質量管理體系ISO 9001:2015 GB/T 19001-2016    證書編號: 00124Q34771R2M/1100
通過國際醫療器械-質量管理體系ISO 13485:2016 GB/T 42061-2022    證書編號: CQC24QY10047R0M/1100
京ICP備05066980號-1         京公網安備110107000727號
主站蜘蛛池模板: 超碰人人擦 | 免费福利在线观看 | 沈樵精品国产成av片 | 日韩av在线免费播放 | 国产三区在线观看 | 日韩欧美的一区二区 | 亚洲成人av免费观看 | 成人欧美一区二区三区A片 亚洲精品成人网站在线 | 永久免费无码国产 | yw193can未满十8网站 | 日韩精品视频在线观看视频 | 一区二区午夜 | 黄色一级视频看看 | 日本中文字幕日韩精品免费 | 善良的表妹hd高清中文 | ye321夜色资源最新地址 | 麻豆国产成人AV在线播放欲色 | 日韩手机在线观看 | 熟女性饥渴一区二区三区 | 麻豆传媒观看 | 国产一级大毛片 | 乱亲女h秽乱长久久久 | 亚洲精选免费 | 人妻系列无码专区无码专区 | 亚洲AV成人精品网站在线播放 | 少妇人妻陈艳和黑人教练 | 成人午夜免费无码视频在线观看 | 无码天堂亚洲国产AV麻豆 | 欧美黑人XXXX又粗又长 | 日本一区免费看 | 一级色毛片 | 中文字幕在线看 | 国内视频精品 | 国产精品久久久久久久久久了 | WWW国产亚洲精品久久 | 在线观看免费视频国产 | 正在播放长泽梓免费观看 | 欧美亚洲国产精品久久高清 | 操的很爽| 银魂在线 | 亚洲欧洲日产国码韩国 |