97久久久精品综合88久久_亚洲国产精品一_久热热国产久热_97操操操_北条麻妃在线免费观看_精品国自产拍天天拍

掃碼關注公眾號           掃碼咨詢技術支持           掃碼咨詢技術服務
  
客服熱線:400-901-9800  客服QQ:4009019800  技術答疑  技術支持  質量反饋  關于我們  聯系我們
小老弟av影院,亚洲无人视频,美女视频黄是免费视频
首頁 > 產品中心 > 標記一抗 > 產品信息
Rabbit Anti-ARA24/FITC Conjugated antibody (bs-3751R-FITC)
訂購熱線:400-901-9800
訂購郵箱:sales@bioss.com.cn
訂購QQ:  400-901-9800
技術支持:techsupport@bioss.com.cn
說 明 書: 100ul  
100ul/2980.00元
大包裝/詢價
產品編號 bs-3751R-FITC
英文名稱 Rabbit Anti-ARA24/FITC Conjugated antibody
中文名稱 FITC標記的雄激素受體相關蛋白24抗體
別    名 Ran; Androgen receptor associated protein 24; ARA 24; ARA24; Gsp1; GTP binding nuclear protein RAN; GTPase Ran; LPS; RAN member RAS oncogene family; Ras like protein TC4; Ras related nuclear protein; RASL2 8; TC 4; TC4; RAN_HUMAN.  
規格價格 100ul/2980元 購買        大包裝/詢價
說 明 書 100ul  
研究領域 細胞生物  免疫學  生長因子和激素  轉錄調節因子  轉運蛋白  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應 (predicted: Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Rabbit, )
產品應用 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 24kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human ARA24
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產品介紹 background:
Ran (ras-related nuclear protein) is a small GTP binding protein belonging to the RAS superfamily that is essential for the translocation of RNA and proteins through the nuclear pore complex. The Ran protein is also involved in control of DNA synthesis and cell cycle progression. Nuclear localization of Ran requires the presence of regulator of chromosome condensation 1 (RCC1). Mutations in Ran disrupt DNA synthesis. Because of its many functions, it is likely that Ran interacts with several other proteins. Ran regulates formation and organization of the microtubule network independently of its role in the nucleus-cytosol exchange of macromolecules. Ran could be a key signaling molecule regulating microtubule polymerization during mitosis. RCC1 generates a high local concentration of Ran-GTP around chromatin which, in turn, induces the local nucleation of microtubules. Ran is an androgen receptor (AR) coactivator that binds differentially with different lengths of polyglutamine within the androgen receptor. Polyglutamine repeat expansion in the AR is linked to Kennedy's disease (X-linked spinal and bulbar muscular atrophy). Ran coactivation of the AR diminishes with polyglutamine expansion within the AR, and this weak coactivation may lead to partial androgen insensitivity during the development of Kennedy's disease.

Function:
GTP-binding protein involved in nucleocytoplasmic transport. Required for the import of protein into the nucleus and also for RNA export. Involved in chromatin condensation and control of cell cycle (By similarity). The complex with BIRC5/ surviving plays a role in mitotic spindle formation by serving as a physical scaffold to help deliver the RAN effector molecule TPX2 to microtubules. Acts as a negative regulator of the kinase activity of VRK1 and VRK2.
Enhances AR-mediated transactivation. Transactivation decreases as the poly-Gln length within AR increases.

Subunit:
Monomer. Also forms a complex with CHC1 and interacts with the AR N-terminal poly-Gln region. The interaction with AR is inversely correlated with the poly-Gln length. Part of a complex consisting of RANBP9, Ran, DYRK1B and COPS5. Found in a nuclear export complex with RANBP3 and XPO1. Component of a nuclear export receptor complex composed of KPNB1, Ran, SNUPN and XPO1. Found in a trimeric export complex with SNUPN, Ran and XPO1. Interacts with RANBP10. In case of HIV-1 infection, found in a complex with HIV-1 Rev, RNAs containing a Rev response element (RRE) and XPO1. Found in a complex with HTLV-1 Rex, RANBP3 and XPO1. Interacts in its GTP-bound form with BIRC5/survivin at S and M phases of the cell cycle. Interacts with TERT; the interaction requires hydrogen peroxide-mediated phosphorylation of TERT and transports TERT to the nucleus. Interacts with MAD2L2. Interacts with RANBP10 (By similarity). Interacts with VRK1 and VRK3. Interacts with isoform 1 and isoform 2 of VRK2.

Subcellular Location:
Nucleus. Cytoplasm. Melanosome.

Tissue Specificity:
Expressed in a variety of tissues.

Similarity:
Belongs to the small GTPase superfamily. Ran family.

Database links:
UniProtKB/Swiss-Prot: P62826.3

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

Ran是真核細胞中含量極豐富的小分子的GTP酶,在核轉運過程中具有十分重要的作用。Ran主要參與了物質的核漿轉運.
版權所有 2004-2026 www.kastlife.cn 北京博奧森生物技術有限公司
通過國際質量管理體系ISO 9001:2015 GB/T 19001-2016    證書編號: 00124Q34771R2M/1100
通過國際醫療器械-質量管理體系ISO 13485:2016 GB/T 42061-2022    證書編號: CQC24QY10047R0M/1100
京ICP備05066980號-1         京公網安備110107000727號
主站蜘蛛池模板: 国产成熟人妻换╳╳╳╳ | 年轻母亲4在线 | 中文无码一区二区视频在线播放 | 欧美在线视频免费看 | 国产三级网 | 国产一级特黄高清在线大片 | 在线中文av | 在线观看深夜福利 | 2019天天干天天操 | 草草亚洲视频 | 草草视频免费 | 91视频在线免费看 | 一区国产精品 | 久久精品国产只有精品66 | 久草在线免费在线观看 | 午夜a毛片 | 在线免费观看黄 | 91精品国产综合久久久久久蜜月 | 亚洲国产精品va在线看黑人动漫 | 欧美三日本三级少妇三级99观看视频 | 中日韩亚洲人成无码网站 | 国产精品99久久久久久小说 | 国产一区二区高清在线观看 | 国产精品免费久久久久久久久久中文 | www久久综合 | 亚洲男人AV免费影院 | 妞干网在线精品视频 | 老司机亚洲精品影院 | 中文字幕色哟哟 | 久久久久免费视频 | 国内免费视频成人精品 | 亚洲精品午夜视频 | 亚洲色爱图小说专区 | 国产999精品久久久影片官网 | 中文字幕69av| 97爱视频 | 野花社区www官网在线观看 | 中文字幕一区二区三区av | 伊人免费视频 | 国产三级午夜理伦三级最新章节 | 蜜桃久久精品一区二区 |