97久久久精品综合88久久_亚洲国产精品一_久热热国产久热_97操操操_北条麻妃在线免费观看_精品国自产拍天天拍

掃碼關注公眾號           掃碼咨詢技術支持           掃碼咨詢技術服務
  
客服熱線:400-901-9800  客服QQ:4009019800  技術答疑  技術支持  質量反饋  關于我們  聯系我們
免费的黄色av,男人的天堂黄色,91羞羞网站
首頁 > 產品中心 > 標記一抗 > 產品信息
Rabbit Anti-Histone H2A/H2A.1/AP Conjugated antibody (bs-3779R-AP)
訂購熱線:400-901-9800
訂購郵箱:sales@bioss.com.cn
訂購QQ:  400-901-9800
技術支持:techsupport@bioss.com.cn
說 明 書: 100ul  
100ul/2980.00元
大包裝/詢價
產品編號 bs-3779R-AP
英文名稱 Rabbit Anti-Histone H2A/H2A.1/AP Conjugated antibody
中文名稱 堿性磷酸酶(AP)標記的組蛋白H2A抗體
別    名 H2a 615; H2A; H2A GL101; H2A histone family member A; H2A.1; H2A.2; H2A/a; H2A/m; H2A/O; H2A/q; H2AFA; H2AFE; H2AFL; H2AFM; H2AFO; H2AFQ; HIST1H2AE; HIST1H2AJ antibody HIST2H2AA; HIST2H2AA3; HIST2H2AB; HIST2H2AC; Histone 1 H2ae; Histone 2 H2aa3; Histone 2 H2ab; Histone 2 H2ac; Histone H2A type 1 B; Histone H2A type 1 C; Histone H2A type 1 E; Histone H2A type 1 J; MGC74460.  
規格價格 100ul/2980元 購買        大包裝/詢價
說 明 書 100ul  
研究領域 腫瘤  細胞生物  免疫學  發育生物學  染色質和核信號  轉錄調節因子  表觀遺傳學  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應 Mouse, Rat,  (predicted: Human, Dog, Pig, Cow, Horse, Rabbit, )
產品應用 IHC-P=1:50-200 IHC-F=1:50-200 ICC=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 14kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human Histone H2A
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產品介紹 background:
Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a member of the histone H2A family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the small histone gene cluster on chromosome 6p22-p21.3. [provided by RefSeq, Jul 2008].

Function:
Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.

Subunit:
The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

Subcellular Location:
Nucleus. Chromosome.

Post-translational modifications:
The chromatin-associated form is phosphorylated on Thr-121 during mitosis (Probable).
Deiminated on Arg-4 in granulocytes upon calcium entry.
Monoubiquitination of Lys-120 by RING1 and RNF2/RING2 complex gives a specific tag for epigenetic transcriptional repression and participates in X chromosome inactivation of female mammals. It is involved in the initiation of both imprinted and random X inactivation. Ubiquitinated H2A is enriched in inactive X chromosome chromatin. Ubiquitination of H2A functions downstream of methylation of 'Lys-27' of histone H3. Monoubiquitination of Lys-120 by RNF2/RING2 can also be induced by ultraviolet and may be involved in DNA repair. Following DNA double-strand breaks (DSBs), it is ubiquitinated through 'Lys-63' linkage of ubiquitin moieties by the E2 ligase UBE2N and the E3 ligases RNF8 and RNF168, leading to the recruitment of repair proteins to sites of DNA damage. Monoubiquitination and ionizing radiation-induced 'Lys-63'-linked ubiquitination are distinct events.
Phosphorylation on Ser-2 is enhanced during mitosis. Phosphorylation on Ser-2 by RPS6KA5/MSK1 directly represses transcription. Acetylation of H3 inhibits Ser-2 phosphorylation by RPS6KA5/MSK1.
Symmetric dimethylation on Arg-4 by the PRDM1/PRMT5 complex may play a crucial role in the germ-cell lineage.

Similarity:
Belongs to the histone H2A family.

Database links:

Entrez Gene: 3012 Human

Entrez Gene: 317772 Human

Entrez Gene: 8335 Human

Entrez Gene: 8337 Human

Entrez Gene: 8338 Human

Entrez Gene: 319166 Mouse

Omim: 142720 Human

Omim: 602786 Human

Omim: 602797 Human

SwissProt: P04908 Human

SwissProt: P28001 Human

SwissProt: P35065 Human

SwissProt: Q93077 Human

SwissProt: Q99878 Human

SwissProt: P10812 Mouse

SwissProt: P22752 Mouse

Unigene: 121017 Human

Unigene: 248174 Human

Unigene: 408067 Human

Unigene: 417332 Human

Unigene: 434195 Human

Unigene: 261665 Mouse



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
版權所有 2004-2026 www.kastlife.cn 北京博奧森生物技術有限公司
通過國際質量管理體系ISO 9001:2015 GB/T 19001-2016    證書編號: 00124Q34771R2M/1100
通過國際醫療器械-質量管理體系ISO 13485:2016 GB/T 42061-2022    證書編號: CQC24QY10047R0M/1100
京ICP備05066980號-1         京公網安備110107000727號
主站蜘蛛池模板: 日韩精品一区二区三 | 91精品综合久久久久久3u8 | av一区在线观看 | 亚洲精品无码成案A片在线 www久久 | 免费黄网在线 | 一级黄色录像影片夫妻性生活影片 | 欧美国产成人精品二区芒果视频 | 91mv.cool在线观看 | 欧美阿v视频 | 欧美群交射精内射颜射潮喷 | 日99久9在线免费 | 欧美不卡一区 | 探花bt| 成人午夜做爰视频免费看 | 好大好硬好爽18禁视频免费 | 成年站免费网站看V片在线 成人亚洲免费视频 | 激情国产AV做激情国产爱 | 麻豆人妻少妇精品无码专区 | 国产成人精品午夜福利软件 | 日韩无马砖区芒果 | 伊人二本二区 | 国产区精品福利在线社区 | 色婷婷五月综合久久 | www.黄色大片 | 精品国产鲁一鲁一区二区三区 | 国产成人综合亚洲AV第一页 | 香蕉久久久久久久AV网站 | 99热精品只有这里有 | 暖暖视频在线观看免费 | 国精品无码一区二区三区在线A片 | 久久99精品久久久 | 亚洲第一黄色网址 | 久久午夜激情视频 | 国产6区 | 国产清纯91天堂在线观看 | 强插女教师AV在线 | 一本之道中文日本高清 | 国产黄在线看 | 三级毛毛片 | 国产成人综合亚洲A片激情文学 | 国产精品一区二区av日韩在线 |