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Rabbit Anti-FGL2/Biotin Conjugated antibody (bs-0315R-Bio)
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說 明 書: 100ul  
100ul/2980.00元
大包裝/詢價(jià)
產(chǎn)品編號 bs-0315R-Bio
英文名稱 Rabbit Anti-FGL2/Biotin Conjugated antibody
中文名稱 生物素標(biāo)記的凝血酶原酶/纖維蛋白原2抗體
別    名 Fibroleukin; Cytotoxic T-lymphocyte-specific protein; Fibrinogen-like protein 2; Fibrinogen like protein 2; Prothrombinase; Fibroleukin; pT49; T49; FGL2_HUMAN.  
規(guī)格價(jià)格 100ul/2980元 購買        大包裝/詢價(jià)
說 明 書 100ul  
研究領(lǐng)域 免疫學(xué)  t-淋巴細(xì)胞  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) (predicted: Rat, )
產(chǎn)品應(yīng)用 WB=1:50-200 ELISA=1:100-1000 IHC-P=1:50-200 IHC-F=1:50-200 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 49kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from Rat FGL2
亞    型 IgG
純化方法 affinity purified by Protein A
儲(chǔ) 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產(chǎn)品介紹 background:
FGL2 is a secreted protein that is similar to the beta- and gamma-chains of fibrinogen. The carboxyl-terminus of the encoded protein consists of the fibrinogen-related domains (FRED). The encoded protein forms a tetrameric complex which is stabilized by interchain disulfide bonds. It may play a role in physiologic functions at mucosal sites. It is constitutively expressed in cytotoxic T-cells. Lack of expression in other lymphoid- and nonlymphoid-derived cell lines suggested that expression of FGL2 may be restricted to lymphocytes. FGL2 is induced via a mechanism involving IFNG and components of the IFNG signaling pathway, including STAT1 and IRF1.

Function:
May play a role in physiologic lymphocyte functions at mucosal sites

Subunit:
Homotetramer; disulfide-linked.

Subcellular Location:
Secreted.

Tissue Specificity:
Constitutively expressed in cytotoxic T-cells.

Similarity:
Contains 1 fibrinogen C-terminal domain.

Database links:

Entrez Gene: 511711 Cow

Entrez Gene: 10875 Human

Entrez Gene: 14190 Mouse

Entrez Gene: 84586 Rat

Omim: 605351 Human

SwissProt: Q14314 Human

SwissProt: P12804 Mouse

Unigene: 520989 Human

Unigene: 292100 Mouse



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

fgL-2蛋白是新近發(fā)現(xiàn)的一種凝血因子,它通過直接激活凝血酶原啟動(dòng)凝血過程。一 系列實(shí)驗(yàn)證明,該蛋白在肝細(xì)胞壞死中起到重要作用。對乙肝患者肝組織免疫組織化學(xué)染色hfg12在重型乙型肝炎患者高表達(dá)。
凝血酶原酶(簡稱fgl2)蛋白屬于纖維蛋白原家族的一員,由活化的巨噬細(xì)胞表達(dá),具有凝血酶原酶的活力,能催化凝血酶原轉(zhuǎn)化為凝血酶,啟動(dòng)凝血過程.
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