| 產(chǎn)品編號(hào) | bs-0315R-BF488 |
| 英文名稱 | Rabbit Anti-FGL2/BF488 Conjugated antibody |
| 中文名稱 | BF488標(biāo)記的凝血酶原酶/纖維蛋白原2抗體 |
| 別 名 | Fibroleukin; Cytotoxic T-lymphocyte-specific protein; Fibrinogen-like protein 2; Fibrinogen like protein 2; Prothrombinase; Fibroleukin; pT49; T49; FGL2_HUMAN. |
| 規(guī)格價(jià)格 | 100ul/2980元 購(gòu)買 大包裝/詢價(jià) |
| 說(shuō) 明 書 | 100ul |
| 研究領(lǐng)域 | 免疫學(xué) t-淋巴細(xì)胞 |
| 抗體來(lái)源 | Rabbit |
| 克隆類型 | Polyclonal |
| 交叉反應(yīng) | (predicted: Rat, ) |
| 產(chǎn)品應(yīng)用 | IF=1:50-200
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 49kDa |
| 性 狀 | Lyophilized or Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from Rat FGL2 |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 儲(chǔ) 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol |
| 保存條件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 產(chǎn)品介紹 |
background: FGL2 is a secreted protein that is similar to the beta- and gamma-chains of fibrinogen. The carboxyl-terminus of the encoded protein consists of the fibrinogen-related domains (FRED). The encoded protein forms a tetrameric complex which is stabilized by interchain disulfide bonds. It may play a role in physiologic functions at mucosal sites. It is constitutively expressed in cytotoxic T-cells. Lack of expression in other lymphoid- and nonlymphoid-derived cell lines suggested that expression of FGL2 may be restricted to lymphocytes. FGL2 is induced via a mechanism involving IFNG and components of the IFNG signaling pathway, including STAT1 and IRF1. Function: May play a role in physiologic lymphocyte functions at mucosal sites Subunit: Homotetramer; disulfide-linked. Subcellular Location: Secreted. Tissue Specificity: Constitutively expressed in cytotoxic T-cells. Similarity: Contains 1 fibrinogen C-terminal domain. Database links: Entrez Gene: 10875 Human Entrez Gene: 14190 Mouse Omim: 605351 Human SwissProt: Q14314 Human SwissProt: P12804 Mouse Unigene: 520989 Human Unigene: 292100 Mouse Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. fgL-2蛋白是新近發(fā)現(xiàn)的一種凝血因子，它通過(guò)直接激活凝血酶原啟動(dòng)凝血過(guò)程。一 系列實(shí)驗(yàn)證明，該蛋白在肝細(xì)胞壞死中起到重要作用。對(duì)乙肝患者肝組織免疫組織化學(xué)染色hfg12在重型乙型肝炎患者高表達(dá)。 凝血酶原酶(簡(jiǎn)稱fgl2)蛋白屬于纖維蛋白原家族的一員,由活化的巨噬細(xì)胞表達(dá),具有凝血酶原酶的活力,能催化凝血酶原轉(zhuǎn)化為凝血酶,啟動(dòng)凝血過(guò)程. |
