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Rabbit Anti-GNB3/BF594 Conjugated antibody (bs-3943R-BF594)
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說 明 書: 100ul  
100ul/2980.00元
大包裝/詢價
產品編號 bs-3943R-BF594
英文名稱 Rabbit Anti-GNB3/BF594 Conjugated antibody
中文名稱 BF594標記的G蛋白β3抗體/鳥嘌呤核苷酸結合蛋白β亞基3抗體
別    名 G protein beta 3; Gnb3; Guanine nucleotide binding protein (G protein), beta polypeptide 3; Guanine nucleotide binding protein G; Hypertension associated protein; IG; SG; Transducin beta chain 3; Tsubunit beta 3; GBB3_HUMAN.  
規(guī)格價格 100ul/2980元 購買        大包裝/詢價
說 明 書 100ul  
研究領域 腫瘤  心血管  細胞生物  免疫學  轉錄調節(jié)因子  結合蛋白  G蛋白偶聯(lián)受體  G蛋白信號  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應 (predicted: Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit, Sheep, )
產品應用 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 37kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human G protein beta 3
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產品介紹 background:
G proteins are composed of 3 units, alpha, beta and gamma and are involved in the modulation and transduction of various transmembrane signalling systems. There are families of related genes for each subunit. GNB3 encodes a beta subunit. Beta subunits are required for GTPase activity, for replacement of GDP by GTP, regulate alpha subunits and for G protein-effector interactions. A single-nucleotide polymorphism (C825T) in this gene is associated with essential hypertension and obesity and is also associated with the occurrence of the splice variant GNB3-s, which appears to have increased activity.

Function:
Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.

Subunit:
G proteins are composed of 3 units, alpha, beta and gamma. Interacts with RASD2.

Similarity:
Belongs to the WD repeat G protein beta family.
Contains 7 WD repeats.

Database links:

Entrez Gene: 2784 Human

Entrez Gene: 14695 Mouse

Entrez Gene: 60449 Rat

Omim: 139130 Human

SwissProt: P16520 Human

SwissProt: Q61011 Mouse

SwissProt: P52287 Rat

Unigene: 631657 Human

Unigene: 68889 Mouse

Unigene: 27065 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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