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Rabbit Anti-FRA2/APC Conjugated antibody (bs-1188R-APC)
訂購熱線:400-901-9800
訂購郵箱:sales@bioss.com.cn
訂購QQ:  400-901-9800
技術支持:techsupport@bioss.com.cn
說 明 書: 100ul  
100ul/2980.00元
大包裝/詢價
產品編號 bs-1188R-APC
英文名稱 Rabbit Anti-FRA2/APC Conjugated antibody
中文名稱 APC標記的FRA2/FOSL2抗體
別    名 FLJ23306; Fos L2; FOS like antigen 2; Fos related antigen 2; FosL 2; FosL2; FOSL2; FOSL2_HUMAN; FRA 2; fos-related antigen 2.  
規格價格 100ul/2980元 購買        大包裝/詢價
說 明 書 100ul  
研究領域 腫瘤  信號轉導  生長因子和激素  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應 (predicted: Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Rabbit, Sheep, Guinea Pig, )
產品應用 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 36kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human FRA2
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產品介紹 background:
Fos and Jun dimerize to form Activator Protein 1 (AP1), a transcriptional factor that binds to the 12-O-tetradecanoylphorbol 13 acetate (TPA) response element (TRE) of several cellular and viral genes including human collagenase, metallothionein IIa, stromelysin, interleukin 2, SV40 and polyoma. Fos and Jun contain the 'leucine-zipper' motif that allows for dimerization and an adjacent basic domain required for biological activity. The functionally active form of Fos is in a heterodimer with a member of the Jun family. While Jun family members can form functional homodimers, studies indicate that Fos family members do not self-associate and therefore do not bind DNA on their own. The various dimers differ in their ability to transactivate AP1 dependent genes.

Function:
Controls osteoclast survival and size (By similarity). As a dimer with JUN, activates LIF transcription (By similarity). Activates CEBPB transcription in PGE2-activated osteoblasts (By similarity).

Subunit:
Heterodimer

Subcellular Location:
Nuclear

Similarity:
Belongs to the bZIP family. Fos subfamily.
Contains 1 bZIP (basic-leucine zipper) domain.

Database links:

Entrez Gene: 2355 Human

Entrez Gene: 421416 Chicken

Entrez Gene: 14284 Mouse

Entrez Gene: 25446 Rat

Omim: 601575 Human

SwissProt: P18625 Chicken

SwissProt: P15408 Human

SwissProt: P47930 Mouse

SwissProt: P51145 Rat

Unigene: 220971 Human

Unigene: 596972 Human

Unigene: 24684 Mouse

Unigene: 10962 Rat

Unigene: 163577 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

FOSL2蛋白對細胞因子、生長因子、感染或致癌刺激等生理或病理信號發生應答,調節基因的轉錄, 參與細胞的增殖、分化等過程. FOSL2在腫瘤形成及發展過程中, 通過促進細胞增殖、抑制分化、促進腫瘤細胞的侵襲和轉移等過程發揮作用.
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