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Rabbit Anti-CKLF/RBITC Conjugated antibody (bs-2394R-RBITC)
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說 明 書: 100ul  
100ul/2980.00元
大包裝/詢價
產品編號 bs-2394R-RBITC
英文名稱 Rabbit Anti-CKLF/RBITC Conjugated antibody
中文名稱 羅丹明(RBITC)標記的趨化素樣蛋白抗體
別    名 C32; Chemokine-like factor; chemokine-like factor 1; chemokine-like factor 2; chemokine-like factor 3; chemokine-like factor 4; CKLF_HUMAN; CKLF1; CKLF2; CKLF3; CKLF4; CKLFSF2; HSPC224; transmembrane proteolipid; UCK-1; UCK1.  
規格價格 100ul/2980元 購買        大包裝/詢價
說 明 書 100ul  
研究領域 腫瘤  細胞生物  免疫學  細胞分化  淋巴細胞  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應 Human, Mouse, Rat,  (predicted: Rabbit, )
產品應用 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 17kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human CKLF
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產品介紹 background:
The product of this gene is a cytokine. Cytokines are small proteins that have an essential role in the immune and inflammatory responses. This gene is one of several chemokine-like factor genes located in a cluster on chromosome 16. The protein encoded by this gene is a potent chemoattractant for neutrophils, monocytes and lymphocytes. It also can stimulate the proliferation of skeletal muscle cells. This protein may play important roles in inflammation and in the regeneration of skeletal muscle. Alternatively spliced transcript variants encoding different isoforms have been identified. Naturally occurring read-through transcription occurs between this locus and the neighboring locus CMTM1 (CKLF-like MARVEL transmembrane domain containing 1).[provided by RefSeq, Feb 2011]

Function:
May play an important role in inflammation and regeneration of skeletal muscle. Partly inhibited by interleukin 10.
Isoform 1 has chemotactic response in rat monocytes, neutrophils, and lymphocytes.

Subcellular Location:
Isoform 1: Secreted.
Isoform 2: Membrane; Multi-pass membrane protein.
Isoform 4: Membrane; Multi-pass membrane protein.

Tissue Specificity:
Isoform 1, isoform 2, isoform 3 and isoform 4 have highest expression levels in adult spleen, lung, testis, ovary, peripheral blood leukocyte, placenta, pancreas, and in fetal brain, skeletal muscle, thymus and heart. Lower expression levels in adult skeletal muscle, liver, thymus colon, prostate and fetal spleen and liver.

Similarity:
Belongs to the chemokine-like factor family.
Contains 1 MARVEL domain.

Database links:

Entrez Gene: 51192 Human

Entrez Gene: 75458 Mouse

Entrez Gene: 245978 Rat

Omim: 607885 Human

SwissProt: Q9UBR5 Human

SwissProt: Q9DAS1 Mouse

SwissProt: Q9JK79 Rat

Unigene: 15159 Human

Unigene: 81197 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

CKLF(趨化素樣因子)是人類趨化素樣因子超家族CKLFSF(Chemokine-like Factor Super Family,趨化素樣因子超家族)中的一員,趨化因子能使細胞發生趨化運動的小分子細胞因子。趨化因子結構和功能比較相似,分子量多在10-20kDa之間,對嗜中性粒細胞、淋巴細胞、單核細胞等多種細胞有趨化活性。
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