97久久久精品综合88久久_亚洲国产精品一_久热热国产久热_97操操操_北条麻妃在线免费观看_精品国自产拍天天拍

掃碼關注公眾號           掃碼咨詢技術支持           掃碼咨詢技術服務
  
客服熱線:400-901-9800  客服QQ:4009019800  技術答疑  技術支持  質量反饋  關于我們  聯系我們
超碰在线97中文字幕,天天干天天舔,色吊丝在线观看
首頁 > 產品中心 > 標記一抗 > 產品信息
Rabbit Anti-Insig1/BF555 Conjugated antibody (bs-5074R-BF555)
訂購熱線:400-901-9800
訂購郵箱:sales@bioss.com.cn
訂購QQ:  400-901-9800
技術支持:techsupport@bioss.com.cn
說 明 書: 100ul  
100ul/2980.00元
大包裝/詢價
產品編號 bs-5074R-BF555
英文名稱 Rabbit Anti-Insig1/BF555 Conjugated antibody
中文名稱 BF555標記的胰島素誘導基因1抗體
別    名 CL 6; CL6; INSIG 1; INSIG 1 membrane protein; INSIG1 membrane protein; Insulin induced gene 1; Insulin induced gene 1 protein; insulin induced gene-1; insulin induced gene1; MGC1405; INSI1_HUMAN.  
規格價格 100ul/2980元 購買        大包裝/詢價
說 明 書 100ul  
研究領域 腫瘤  細胞生物  免疫學  信號轉導  細胞凋亡  轉錄調節因子  糖尿病  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應 Mouse,  (predicted: Human, Rat, Chicken, Dog, Pig, Cow, Rabbit, Sheep, )
產品應用 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 30kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human Insig1
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產品介紹 background:
Oxysterols regulate cholesterol homeostasis through liver X receptor (LXR) and sterol regulatory element binding protein (SREBP) mediated signaling pathway. Insig1 is an insulin-induced gene. It encodes an endoplasmic reticulum (ER) membrane protein that plays a critical role in regulating cholesterol concentrations in cells. Insig1 binds to the sterol-sensing domains of SREBP cleavage-activating protein (SCAP) and HMG CoA reductase, and is essential for the sterol-mediated trafficking of the two proteins. It may also play a role in growth and differentiation of tissues involved in metabolic control, and may play a regulatory role during G0/G1 transition of cell growth.

Function:
Mediates feedback control of cholesterol synthesis by controlling SCAP and HMGCR. Functions by blocking the processing of sterol regulatory element-binding proteins (SREBPs). Capable of retaining the SCAP-SREBF2 complex in the ER thus preventing it from escorting SREBPs to the Golgi. Initiates the sterol-mediated ubiquitin-mediated endoplasmic reticulum-associated degradation (ERAD) of HMGCR via recruitment of the reductase to the ubiquitin ligase, AMFR/gp78. May play a role in growth and differentiation of tissues involved in metabolic control. May play a regulatory role during G0/G1 transition of cell growth.

Subunit:
Binds to the SCAP-SREBF2 complex only in the presence of sterols. Interacts with RNF139. Interacts with HMGCR (via its SSD); the interaction, accelerated by sterols, leads to the recruitment of HMGCR to AMFR/gp78 for its ubiquitination by the sterol-mediated ERAD pathway. Interacts with AMFR/gp78 (via its membrane domain); the interaction recruits HMCR at the ER membrane for its ubiquitination and degradation by the sterol-mediated ERAD pathway.

Subcellular Location:
Endoplasmic reticulum membrane; Multi-pass membrane protein.

Tissue Specificity:
Expressed in all tissues tested with highest expression in the liver.

Post-translational modifications:
Ubiquitinated. Subsequent to sterol deprivation, the SCAP-SREBF2 complex becomes dissociated from INSIG1, is then ubiquitinated and degraded in proteasomes. Although ubiquitination is required for rapid INSIG1 degradation, it is not required for release of the SCAP-SREBP complex. Ubiquitinated by RNF139.

Similarity:
Belongs to the INSIG family.

Database links:

Entrez Gene: 3638 Human

Entrez Gene: 231070 Mouse

Entrez Gene: 64194 Rat

Omim: 602055 Human

SwissProt: O15503 Human

SwissProt: Q8BGI3 Mouse

SwissProt: Q08755 Rat

Unigene: 520819 Human

Unigene: 30221 Mouse

Unigene: 772 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

胰島素誘導基因1在參與代謝控制的組織生長和分化中發揮作用,在細胞生長的G0/G1期的轉變過程中發揮調節作用.
版權所有 2004-2026 www.kastlife.cn 北京博奧森生物技術有限公司
通過國際質量管理體系ISO 9001:2015 GB/T 19001-2016    證書編號: 00124Q34771R2M/1100
通過國際醫療器械-質量管理體系ISO 13485:2016 GB/T 42061-2022    證書編號: CQC24QY10047R0M/1100
京ICP備05066980號-1         京公網安備110107000727號
主站蜘蛛池模板: 大陆熟女丰满XXXXX富婆 | 青草香蕉视频 | 色婷婷五月综合丁香中文字幕 | 亚洲精品成人片在线播放4388 | 国产女人高潮叫床视频 | 欧美高潮喷水HD | 国产啪视频| 国产欧美一区二区三区久久人妖 | 护士故意露出奶头让我吃奶 | 性国产日韩欧美一区二区在线 | 亚洲黄色免费看 | www.狠狠插.com| 日本一级a毛片免费观看 | 337P亚洲日本中国大胆69 | 香蕉久久综合 | 亚洲丰满熟妇XXXX性A片 | 脱了老师内裤猛烈进入在线观看 | 最近中文字幕免费MV在线视频 | 久热无码中文视频在线 | 日日夜夜一区二区 | 激情综合色综合啪啪五月丁香搜索 | 日本免费在线看 | 区区久久久狼 | 自拍一级片 | 国产成人无码一二三区视频 | 亚洲aⅴ久久精品蜜桃小仓由菜 | 日本一级待黄大片 | 国产夜色av | 怡红院成永久免费人视频视色 | jizz国产免费观看 | 秋霞无码一区二区视频在线观看 | 国产一区二区高清在线观看 | 青草福利| 国产观看视频 | 国产一区二区三区国产精品 | 亚洲成AV人片一区二区密柚 | 日本无遮挡色又黄的视频 | 剑来在线观看 | 性国产牲交XXXXX视频 | 亚洲精品AⅤ在线国自产拍 美国人泡妞xxxxwww免费看 | 在线观看欧美一区 |