97久久久精品综合88久久_亚洲国产精品一_久热热国产久热_97操操操_北条麻妃在线免费观看_精品国自产拍天天拍

掃碼關注公眾號           掃碼咨詢技術支持           掃碼咨詢技術服務
  
客服熱線:400-901-9800  客服QQ:4009019800  技術答疑  技術支持  質量反饋  關于我們  聯系我們
777奇米四色眼影九色,精品福利在线,97人妻人人澡人人爽国产
首頁 > 產品中心 > 標記一抗 > 產品信息
Rabbit Anti-RPS6KB1/BF647 Conjugated antibody (bs-6370R-BF647)
訂購熱線:400-901-9800
訂購郵箱:sales@bioss.com.cn
訂購QQ:  400-901-9800
技術支持:techsupport@bioss.com.cn
說 明 書: 100ul  
100ul/2980.00元
大包裝/詢價
產品編號 bs-6370R-BF647
英文名稱 Rabbit Anti-RPS6KB1/BF647 Conjugated antibody
中文名稱 BF647標記的核糖體p70 S6蛋白激酶抗體
別    名 p70(S6K)-alpha; ribosomal protein S6 kinase; p70 S6 Kinase; P70 Beta1; KS6B1_HUMAN; Ribosomal protein S6 kinase beta-1; 70 kDa ribosomal protein S6 kinase 1; P70S6K1; p70-S6K 1; Ribosomal protein S6 kinase I; Serine/threonine-protein kinase 14A; p70 ribosomal S6 kinase alpha; p70 S6 kinase alpha; p70 S6K-alpha; p70 S6KA; S6K; PS6K; S6K1; STK14A; p70-S6K; p70 S6KA; p70-alpha; S6K-beta-1; p70(S6K)-alpha.  
規格價格 100ul/2980元 購買        大包裝/詢價
說 明 書 100ul  
研究領域 腫瘤  細胞生物  染色質和核信號  信號轉導  細胞凋亡  激酶和磷酸酶  線粒體  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應 (predicted: Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Rabbit, )
產品應用 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 70kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human p70 S6 kinase alpha
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產品介紹 background:
This gene encodes a member of the RSK (ribosomal S6 kinase) family of serine/threonine kinases. This kinase contains 2 non-identical kinase catalytic domains and phosphorylates several residues of the S6 ribosomal protein. The kinase activity of this protein leads to an increase in protein synthesis and cell proliferation. Amplification of the region of DNA encoding this gene and overexpression of this kinase are seen in some breast cancer cell lines. Alternate translational start sites have been described and alternate transcriptional splice variants have been observed but have not been thoroughly characterized. [provided by RefSeq, Jul 2008].

Function:
Serine/threonine-protein kinase that acts downstream of mTOR signaling in response to growth factors and nutrients to promote cell proliferation, cell growth and cell cycle progression. Regulates protein synthesis through phosphorylation of EIF4B, RPS6 and EEF2K, and contributes to cell survival by repressing the pro-apoptotic function of BAD. Under conditions of nutrient depletion, the inactive form associates with the EIF3 translation initiation complex. Upon mitogenic stimulation, phosphorylation by the mammalian target of rapamycin complex 1 (mTORC1) leads to dissociation from the EIF3 complex and activation. The active form then phosphorylates and activates several substrates in the preinitiation complex, including the EIF2B complex and the cap-binding complex component EIF4B. Also controls translation initiation by phosphorylating a negative regulator of EIF4A, PDCD4, targeting it for ubiquitination and subsequent proteolysis. Promotes initiation of the pioneer round of protein synthesis by phosphorylating POLDIP3/SKAR. In response to IGF1, activates translation elongation by phosphorylating EEF2 kinase (EEF2K), which leads to its inhibition and thus activation of EEF2. Also plays a role in feedback regulation of mTORC2 by mTORC1 by phosphorylating RICTOR, resulting in the inhibition of mTORC2 and AKT1 signaling. Mediates cell survival by phosphorylating the pro-apoptotic protein BAD and suppressing its pro-apoptotic function. Phosphorylates mitochondrial URI1 leading to dissociation of a URI1-PPP1CC complex. The free mitochondrial PPP1CC can then dephosphorylate RPS6KB1 at 'Thr-412', which is proposed to be a negative feedback mechanism for the RPS6KB1 anti-apoptotic function. Mediates TNF-alpha-induced insulin resistance by phosphorylating IRS1 at multiple serine residues, resulting in accelerated degradation of IRS1. In cells lacking functional TSC1-2 complex, constitutively phosphorylates and inhibits GSK3B. May be involved in cytoskeletal rearrangement through binding to neurabin.

Subunit:
Interacts with PPP1R9A/neurabin-1.

Subcellular Location:
Cell junction, synapse, synaptosome. Mitochondrion outer membrane. Isoform Alpha I: Nucleus. Cytoplasm. Isoform Alpha II: Cytoplasm.

Tissue Specificity:
Widely expressed.

Post-translational modifications:
Phosphorylation at Thr-412 is regulated by mTORC1. The phosphorylation at this site is maintained by an agonist-dependent autophosphorylation mechanism. Activated by phosphorylation at Thr-252 by PDPK1. Dephosphorylation by PPP1CC at Thr-412 in mitochondrion.

Similarity:
Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily.
Contains 1 AGC-kinase C-terminal domain.
Contains 1 protein kinase domain.

Database links:

Entrez Gene: 6198 Human

Entrez Gene: 72508 Mouse

Entrez Gene: 100009260 Rabbit

Entrez Gene: 83840 Rat

Omim: 608938 Human

SwissProt: Q6TJY3 Cow

SwissProt: P23443 Human

SwissProt: Q8BSK8 Mouse

SwissProt: P67998 Rabbit

Unigene: 463642 Human

Unigene: 394280 Mouse

Unigene: 4042 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
版權所有 2004-2026 www.kastlife.cn 北京博奧森生物技術有限公司
通過國際質量管理體系ISO 9001:2015 GB/T 19001-2016    證書編號: 00124Q34771R2M/1100
通過國際醫療器械-質量管理體系ISO 13485:2016 GB/T 42061-2022    證書編號: CQC24QY10047R0M/1100
京ICP備05066980號-1         京公網安備110107000727號
主站蜘蛛池模板: 欧美日韩国产免费一区二区三区 | 草草草视频 | 欧美黄色网 | 91伊人 | chinese45丰满成熟hd | 亚洲日韩中文在线精品第一 | 久久精品黄色 | 视频一区视频二区视频三区视频四区国产 | 亚洲国产精品视频一区二区 | 日本久久综合 | 在线精品亚洲一区二区动态图 | 成人免费在线网站 | 国产在线精品一区二区 | 无码精品每日更新精品久久久 | 日本在线播放一二三区 | 人人澡人人曰人人摸看 | 给我免费观看片在线观看 | 成人精品一区二区三区免费看 | 中文字幕在线观看不卡视频 | 宝宝好涨水快流出来免费视频 | 国产一区免费在线观看 | 99在线在线视频免费视频观看 | 日韩一区国产在线观看 | 久久夜色精品国产欧美 | 久久久久久久爱 | 999国产在线| 国产免费一区二区在线a片视频 | 国产女人高潮叫床视频 | 亚卅在线有码无码免费 | 性做久久久 | 各种场合大胆露出在线看 | AV中文无码乱人伦在线观看 | 国产成人精品视频免费 | 久久婷婷日日澡天天添 | 久久99免费视频 | 精品少妇一区二区三区在线播放 | 在线中文免费视频 | 国产精品久久精品 | 伊人欧美视频 | 日韩AV东京社区男人的天堂 | 草久久久久 |