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Rabbit Anti-PSRC1/PE Conjugated antibody (bs-7619R-PE)
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說 明 書: 100ul  
100ul/2980.00元
大包裝/詢價
產品編號 bs-7619R-PE
英文名稱 Rabbit Anti-PSRC1/PE Conjugated antibody
中文名稱 PE標記的富含脯氨酸/絲氨酸卷曲螺旋蛋白1抗體
別    名 DDA3; Differential display and activated by p53; FP3214; p53-regulated DDA3; Proline/serine-rich coiled-coil 1; proline/serine-rich coiled-coil protein 1; PSRC1_HUMAN.  
規格價格 100ul/2980元 購買        大包裝/詢價
說 明 書 100ul  
研究領域 腫瘤  細胞生物  細胞凋亡  細胞周期蛋白  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應 (predicted: Human, Mouse, Rat, Dog, Pig, Cow, Rabbit, )
產品應用 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 39kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human PSRC1
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產品介紹 background:
This gene encodes a proline rich protein. Studies of the related mouse gene suggest that this gene is regulated by p53 and may participate in p53 mediated growth suppression. Alternatively spliced transcript variants encoding different isoforms have been described.

Function:
Required for normal progression through mitosis. Required for normal congress of chromosomes at the metaphase plate, and for normal rate of chromosomal segregation during anaphase. Plays a role in the regulation of mitotic spindle dynamics. Increases the rate of turnover of microtubules on metaphase spindles, and contributes to the generation of normal tension across sister kinetochores. Recruits KIF2A to the mitotic spindle and spindle poles. May participate in p53/TP53-regulated growth suppression.

Subunit:
Interacts with APC2 (By similarity). Interacts with KIF2A.

Subcellular Location:
Cytoplasm. Cytoplasm, cytoskeleton, spindle. Cytoplasm, cytoskeleton, spindle pole. Note=Detected at the mitotic spindle and spindle poles. Diffusely distributed throughout the cell during interphase.

Tissue Specificity:
Widely expressed in adult and fetal tissues, with highest expression in the adult brain and fetal thymus. Not detected in adult skeletal muscle.

Post-translational modifications:
Phosphorylated during mitosis.

Similarity:
Belongs to the PSRC1 family.

Database links:
UniProtKB/Swiss-Prot: Q6PGN9.1

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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