97久久久精品综合88久久_亚洲国产精品一_久热热国产久热_97操操操_北条麻妃在线免费观看_精品国自产拍天天拍

掃碼關注公眾號           掃碼咨詢技術支持           掃碼咨詢技術服務
  
客服熱線:400-901-9800  客服QQ:4009019800  技術答疑  技術支持  質量反饋  關于我們  聯系我們
密臀av网站,99久久亚洲,欧美一区二区在线观看视频
首頁 > 產品中心 > 標記一抗 > 產品信息
Rabbit Anti-SLC12A3/RBITC Conjugated antibody (bs-7694R-RBITC)
訂購熱線:400-901-9800
訂購郵箱:sales@bioss.com.cn
訂購QQ:  400-901-9800
技術支持:techsupport@bioss.com.cn
說 明 書: 100ul  
100ul/2980.00元
大包裝/詢價
產品編號 bs-7694R-RBITC
英文名稱 Rabbit Anti-SLC12A3/RBITC Conjugated antibody
中文名稱 羅丹明(RBITC)標記的鈉氯離子轉運蛋白抗體
別    名 Na Cl symporter; Na-Cl symporter; NaCl electroneutral thiazide sensitive cotransporter; NCCT; S12A3_HUMAN; slc12a3; Solute carrier family 12 (sodium/chloride transporters) member 3; Solute carrier family 12 member 3; Thiazide sensitive Na Cl cotransporter; Thiazide sensitive sodium chloride cotransporter; Thiazide-sensitive sodium-chloride cotransporter; TSC.  
規格價格 100ul/2980元 購買        大包裝/詢價
說 明 書 100ul  
研究領域 腫瘤  心血管  細胞生物  通道蛋白  轉運蛋白  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應 (predicted: Human, Mouse, Rat, Dog, Cow, Rabbit, )
產品應用 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 113kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human SLC12A3/NCCT
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產品介紹 background:
Na-K-Cl cotransporters (NKCC) are channel proteins that aid in the transcellular movement of chloride across both secretory and absorptive epithelia. NKCC1 is expressed in muscle cells, neurons, and red blood cells. In the basolateral membrane of secretory epithelia, NKCC1 mediates active chloride secretion. The gene encoding human NKCC1 maps to chromosome 5q23.3. In mice, disruption of the NKCC1 gene leads to deafness and impaired balance. NKCC2 is specifically expressed in the kidney where it mediates active reabsorption of sodium chloride in the thick ascending limb of the loop of Henle. NKCC2 is sensitive to the clinically important diuretics furosemide and bumetanide. The gene encoding human NKCC2 maps to chromosome 15q15-q21 and mutations in this gene lead to Bartter’s syndrome, an inherited hypokalaemic alkalosis. NCCT is a thiazide-sensitive Na-Cl cotransporter that is primarily expressed in the distal convoluted tubule of the kidney where it accounts for a significant fraction of net renal sodium reabsorption. The gene for human NCCT map to chromosome 16q13. Mutations in the gene encoding NCCT cause Gitelman’s syndrome, a subset of Bartter’s syndrome.

Function:
Electrically silent transporter system. Mediates sodium and chloride reabsorption.

Subunit:
Interacts with KLHL3.

Subcellular Location:
Membrane.

Tissue Specificity:
Predominant in kidney.

Post-translational modifications:
Ubiquitinated; ubiquitination is essential for regulation of endocytosis (By similarity). May be ubiquitinated by the BCR(KLHL3) complex.

DISEASE:
Defects in SLC12A3 are the cause of Gitelman syndrome (GS). GS is an autosomal recessive disorder characterized by hypokalemic alkalosis in combination with hypomagnesemia, low urinary calcium, and increased renin activity associated with normal blood pressure. Patients are often asymptomatic or present transient periods of muscular weakness and tetany, usually accompanied by abdominal pain, vomiting and fever. The phenotype is highly heterogeneous in terms of age at onset and severity. Cardinal features such as hypocalciuria and hypomagnesemia might also change during the life cycle of a given patient. GS has overlapping features with Bartter syndrome.

Similarity:
Belongs to the SLC12A transporter family.

Database links:

Entrez Gene: 6559 Human

Entrez Gene: 20497 Mouse

Entrez Gene: 54300 Rat

Omim: 600968 Human

SwissProt: P55017 Human

SwissProt: P59158 Mouse

SwissProt: P55018 Rat

Unigene: 669115 Human

Unigene: 25804 Mouse

Unigene: 10467 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
版權所有 2004-2026 www.kastlife.cn 北京博奧森生物技術有限公司
通過國際質量管理體系ISO 9001:2015 GB/T 19001-2016    證書編號: 00124Q34771R2M/1100
通過國際醫療器械-質量管理體系ISO 13485:2016 GB/T 42061-2022    證書編號: CQC24QY10047R0M/1100
京ICP備05066980號-1         京公網安備110107000727號
主站蜘蛛池模板: 又硬又粗又大一区二区三区视频 | 成人小视频在线观看免费 | 天堂а在线最新版在线 | 91无码视频在线观看 | 农村夫妇大白天啪啪 | 国产AV无码精品国产精品 | 国产精品中文字幕在线观看 | 久久亚洲aⅴ永久无码精品 精品久久久久久久久久ntr影视 | 九九热在线视频观看这里只有精品 | 中文字幕乱码中文乱码51精品 | 久久精品国产精品国产精品污 | 91年精品国产 | 一级二级三级毛片 | 久久国产亚洲日韩 | 亚洲狠狠婷婷综合久久久久图片 | 91草视频 | 91视频免费下 | 中文无码精品a∨在线 | 第一区在线观看免费国语入口 | 亚洲精品久久无码AV片亚洲有色 | 麻豆一区二区三区视频 | 四色导航 | 国产一区二区久久 | 狠狠色婷婷久久一区二区三区91 | 亚洲视频免费在线播放 | 天堂在线精品视频 | 999免费在线视频 | 精品国产一区二区三区四区 | 热久久久久久久久 | 日韩精品一区二区三区中文无码 | 亚洲最新在线视频 | 嫩草tv| 国产一区二区在线在线 | 秋霞无码一区二区视频在线观看 | 国产香蕉一区二区在线网站 | 成人片段大有上在线观看 | 欧美日韩不卡一区二区 | 九九精品久久久 | 特级全黄男女交高清视频在线观看 | 日韩一级淫片 | 成人av中文解说水果派在线观看 |