97久久久精品综合88久久_亚洲国产精品一_久热热国产久热_97操操操_北条麻妃在线免费观看_精品国自产拍天天拍

掃碼關(guān)注公眾號(hào)           掃碼咨詢技術(shù)支持           掃碼咨詢技術(shù)服務(wù)
  
客服熱線:400-901-9800  客服QQ:4009019800  技術(shù)答疑  技術(shù)支持  質(zhì)量反饋  關(guān)于我們  聯(lián)系我們
久久的爱,中文字幕日韩人妻不卡一区,91琪琪在线
Rabbit Anti-SLC12A3/BF488 Conjugated antibody (bs-7694R-BF488)
訂購(gòu)熱線:400-901-9800
訂購(gòu)郵箱:sales@bioss.com.cn
訂購(gòu)QQ:  400-901-9800
技術(shù)支持:techsupport@bioss.com.cn
說(shuō) 明 書: 100ul  
100ul/2980.00元
大包裝/詢價(jià)
產(chǎn)品編號(hào) bs-7694R-BF488
英文名稱 Rabbit Anti-SLC12A3/BF488 Conjugated antibody
中文名稱 BF488標(biāo)記的鈉氯離子轉(zhuǎn)運(yùn)蛋白抗體
別    名 Na Cl symporter; Na-Cl symporter; NaCl electroneutral thiazide sensitive cotransporter; NCCT; S12A3_HUMAN; slc12a3; Solute carrier family 12 (sodium/chloride transporters) member 3; Solute carrier family 12 member 3; Thiazide sensitive Na Cl cotransporter; Thiazide sensitive sodium chloride cotransporter; Thiazide-sensitive sodium-chloride cotransporter; TSC.  
規(guī)格價(jià)格 100ul/2980元 購(gòu)買        大包裝/詢價(jià)
說(shuō) 明 書 100ul  
研究領(lǐng)域 腫瘤  心血管  細(xì)胞生物  通道蛋白  轉(zhuǎn)運(yùn)蛋白  
抗體來(lái)源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) (predicted: Human, Mouse, Rat, Dog, Cow, Rabbit, )
產(chǎn)品應(yīng)用 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 113kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human SLC12A3/NCCT
亞    型 IgG
純化方法 affinity purified by Protein A
儲(chǔ) 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產(chǎn)品介紹 background:
Na-K-Cl cotransporters (NKCC) are channel proteins that aid in the transcellular movement of chloride across both secretory and absorptive epithelia. NKCC1 is expressed in muscle cells, neurons, and red blood cells. In the basolateral membrane of secretory epithelia, NKCC1 mediates active chloride secretion. The gene encoding human NKCC1 maps to chromosome 5q23.3. In mice, disruption of the NKCC1 gene leads to deafness and impaired balance. NKCC2 is specifically expressed in the kidney where it mediates active reabsorption of sodium chloride in the thick ascending limb of the loop of Henle. NKCC2 is sensitive to the clinically important diuretics furosemide and bumetanide. The gene encoding human NKCC2 maps to chromosome 15q15-q21 and mutations in this gene lead to Bartter’s syndrome, an inherited hypokalaemic alkalosis. NCCT is a thiazide-sensitive Na-Cl cotransporter that is primarily expressed in the distal convoluted tubule of the kidney where it accounts for a significant fraction of net renal sodium reabsorption. The gene for human NCCT map to chromosome 16q13. Mutations in the gene encoding NCCT cause Gitelman’s syndrome, a subset of Bartter’s syndrome.

Function:
Electrically silent transporter system. Mediates sodium and chloride reabsorption.

Subunit:
Interacts with KLHL3.

Subcellular Location:
Membrane.

Tissue Specificity:
Predominant in kidney.

Post-translational modifications:
Ubiquitinated; ubiquitination is essential for regulation of endocytosis (By similarity). May be ubiquitinated by the BCR(KLHL3) complex.

DISEASE:
Defects in SLC12A3 are the cause of Gitelman syndrome (GS). GS is an autosomal recessive disorder characterized by hypokalemic alkalosis in combination with hypomagnesemia, low urinary calcium, and increased renin activity associated with normal blood pressure. Patients are often asymptomatic or present transient periods of muscular weakness and tetany, usually accompanied by abdominal pain, vomiting and fever. The phenotype is highly heterogeneous in terms of age at onset and severity. Cardinal features such as hypocalciuria and hypomagnesemia might also change during the life cycle of a given patient. GS has overlapping features with Bartter syndrome.

Similarity:
Belongs to the SLC12A transporter family.

Database links:

Entrez Gene: 6559 Human

Entrez Gene: 20497 Mouse

Entrez Gene: 54300 Rat

Omim: 600968 Human

SwissProt: P55017 Human

SwissProt: P59158 Mouse

SwissProt: P55018 Rat

Unigene: 669115 Human

Unigene: 25804 Mouse

Unigene: 10467 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
版權(quán)所有 2004-2026 www.kastlife.cn 北京博奧森生物技術(shù)有限公司
通過(guò)國(guó)際質(zhì)量管理體系ISO 9001:2015 GB/T 19001-2016    證書編號(hào): 00124Q34771R2M/1100
通過(guò)國(guó)際醫(yī)療器械-質(zhì)量管理體系ISO 13485:2016 GB/T 42061-2022    證書編號(hào): CQC24QY10047R0M/1100
京ICP備05066980號(hào)-1         京公網(wǎng)安備110107000727號(hào)
主站蜘蛛池模板: 在线观看se | 亚洲精品日本无v一区 | 亚洲肉感在线 | 国产亚洲一区二区三区四区 | 精品日韩卡1二2卡3卡4卡乱码 | 自拍偷拍另类亚洲 | 国产成人无码一二三区视频 | 久久av资源| 白丝美女被操黄色视频国产免费 | 日韩美一区 | 少妇爆乳无码专区网站 | 国产三级日本三级在线播放 | 免费av免费看 | 中文无码亚洲精品字幕 | 免费无码中文字幕A级毛片 中文字幕一区二区在线视频 | 亚洲国产精品一区二区尤物区 | 无遮无挡爽爽免费视频 | 国产三级精品三级在 | 无码专区在线观看韩国 | 国产69精品久久久久777糖心 | 亚洲经典三级 | 亚洲第一页在线视频 | 国产精品日韩AV在线播放 | 色情久久久AV熟女人妻网站 | 丰满老熟女毛片hd | 国产特级黄色片 | 中日韩一级视频 | 九九99无码精品视频在线观看 | 影音先锋男人站 | 中文字幕亚洲精品无码 | 精品久久AⅤ人妻中文字幕 国产高清无码黄片亚洲大尺度视频 | 毛片一级网站 | 乱中年女人伦av三区 | 欧美日韩高清一区二区三区 | 中文无字幕一区二区三区 | 亚洲综合无码日韩 | 欧美性猛交XXXX三人 | 国产麻豆一区二区三区在线观看 | 女人张开腿让男人桶爽 | 色播影院性播影院私人影院 | av天堂永久资源网av天堂 |