97久久久精品综合88久久_亚洲国产精品一_久热热国产久热_97操操操_北条麻妃在线免费观看_精品国自产拍天天拍

掃碼關(guān)注公眾號           掃碼咨詢技術(shù)支持           掃碼咨詢技術(shù)服務(wù)
  
客服熱線:400-901-9800  客服QQ:4009019800  技術(shù)答疑  技術(shù)支持  質(zhì)量反饋  關(guān)于我們  聯(lián)系我們
国产精品sss在线观看av,亚洲激情三区,中文字幕在线色
Rabbit Anti-NIRF /Gold Conjugated antibody (bs-6389R-Gold)
訂購熱線:400-901-9800
訂購郵箱:sales@bioss.com.cn
訂購QQ:  400-901-9800
技術(shù)支持:techsupport@bioss.com.cn
說 明 書: 100ul(10nm  15nm  35nm
100ul/2980.00元
大包裝/詢價(jià)
產(chǎn)品編號 bs-6389R-Gold
英文名稱 Rabbit Anti-NIRF /Gold Conjugated antibody
中文名稱 膠體金標(biāo)記的環(huán)指蛋白107抗體
別    名 E3 ubiquitin-protein ligase UHRF2; Np95 like RING finger protein; Np95-like ring finger protein; Np95/ICBP90 like RING finger protein; Np95/ICBP90-like RING finger protein; Nuclear protein 97; Nuclear zinc finger protein Np97; RING finger protein 107; RNF 107; RP11-472F14.2; Ubiquitin like containing PHD and RING finger domains protein 2; Ubiquitin-like PHD and RING finger domain-containing protein 2; Ubiquitin-like-containing PHD and RING finger domains protein 2; Uhrf2; UHRF2_HUMAN.  
規(guī)格價(jià)格 100ul/2980元 購買        大包裝/詢價(jià)
說 明 書 100ul(10nm  15nm  35nm
研究領(lǐng)域 細(xì)胞生物  細(xì)胞周期蛋白  鋅指蛋白  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) (predicted: Human, Mouse, Rat, Dog, Cow, )
產(chǎn)品應(yīng)用 IEM=1:20-200 ICA=1:20-200 ChIP=1:20-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 90kDa
性    狀 Lyophilized or Liquid
濃    度 0.4mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human NIRF
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.02M TBS(pH8.2) with 1% BSA, 0.03% Proclin300.
保存條件 Store at 2-8 oC for 3-6 months. Avoid repeated freeze/thaw cycles.
產(chǎn)品介紹 background:
E3 ubiquitin-protein ligase which mediates ubiquitination and subsequent proteasomal degradation of PCNP. May participate in methylation-dependent transcriptional regulation. Important for G1/S transition. Overexpression causes G1 phase cell arrest.

Function:
E3 ubiquitin-protein ligase that is an intermolecular hub protein in the cell cycle network. Through cooperative DNA and histone binding, may contribute to a tighter epigenetic control of gene expression in differentiated cells. Ubiquitinates cyclins, CCND1 and CCNE1, in an apparently phosphorylation-independent manner and induces G1 arrest. Also ubiquitinates PCNP leading to its degradation by the proteasome. E3 SUMO-, but not ubiquitin-, protein ligase for ZNF131.

Subunit:
Homodimer; disulfide-linked. Binds methylated CpG containing oligonucleotides. Interacts with H3: the interaction has a preference for the 'Lys-9' trimethylated form of H3 (H3K9me3). Interacts with PCNP, HDAC1 and CDK2 (inactive form). Component of a complex at least composed of UHRF2, CDK2 and CCNE1. Interacts directly with CCNE1; the interaction ubiquitinates CCNE1 and appears independent of CCNE1 phosphorylation. Interacts with CCND1; the interaction ubiquitinates CCND1 and appears independent of CCND1 phosphorylation. Interacts with p53/TP53 and RB1. Interacts with UBE2I.

Subcellular Location:
Nucleus. Note=Enriched at pericentric heterochromatin (PH). This localization is dependent on the interaction with H3K9me3.

Post-translational modifications:
May be autoubiquitinated; which may lead to proteasomal degradation.
Phosphorylated. Phosphorylation may be mediated by CDK2.
Autosumoylated.

DISEASE:
Note=Associated with various cancers. DNA copy number loss is found in multiple kinds of malignancies originating from the brain, breast, stomach, kidney, hematopoietic tissue and lung.

Similarity:
Contains 1 PHD-type zinc finger.
Contains 1 RING-type zinc finger.
Contains 1 ubiquitin-like domain.
Contains 1 YDG domain.

Database links:

Entrez Gene: 115426 Human

Entrez Gene: 109113 Mouse

Entrez Gene: 309331 Rat

SwissProt: Q96PU4 Human

SwissProt: Q7TMI3 Mouse

Unigene: 493401 Human

Unigene: 313364 Mouse



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
版權(quán)所有 2004-2026 www.kastlife.cn 北京博奧森生物技術(shù)有限公司
通過國際質(zhì)量管理體系ISO 9001:2015 GB/T 19001-2016    證書編號: 00124Q34771R2M/1100
通過國際醫(yī)療器械-質(zhì)量管理體系ISO 13485:2016 GB/T 42061-2022    證書編號: CQC24QY10047R0M/1100
京ICP備05066980號-1         京公網(wǎng)安備110107000727號
主站蜘蛛池模板: 野花香影院在线观看视频免费 | 欧美成人一区二区在线观看 | 国产日产免费高清欧美一区 | 国产剧情AV麻豆香蕉精品 | 欧美老妇视频热 | 特黄A又粗又大又黄又爽A片软件 | 91成年视频| 在线观看亚洲欧美视频免费 | 铜铜铜铜铜铜铜铜好大无打码 | 91精品无毒不卡 | 欧美精品videofree | 日日干夜夜爽 | 一本久道久久综合狠狠爱 | 嫩草院一区二区乱码蜜臀 | 无码人妻精品一区二区三 | 国产一级一片免费播放 | 中国一级片视频 | 国产午夜在线播放 | 神马午夜窝窝 | 无码AV无码一区二区桃花岛 | 91精品国产91久久 | 艳妇乳肉豪妇荡乳AV无码福利 | 国产黄色麻豆视频 | 成人毛片无码一区二区 | 欧美日韩国产限制 | 99久久国产综合精品女不卡 | 99在线在线视频免费视频观看 | 视频成人 | 激情久久久久久久 | 18禁黄网站免费 | 在线免费观看一区二区 | 四虎影视在线影院在线观看 | 午夜私人影院在线观看 | 亚洲AV成人精品网站在线播放 | 精品丝袜国产自在线拍高清 | 国产伦精品一区二区三区四区视频 | 欧美日韩视频免费观看 | 永久久久久 | 永久亚洲成a人片777777 | 小泽玛利亚一区二区在线 | 欧美黑人XXXX又粗又长 |