97久久久精品综合88久久_亚洲国产精品一_久热热国产久热_97操操操_北条麻妃在线免费观看_精品国自产拍天天拍

掃碼關注公眾號           掃碼咨詢技術支持           掃碼咨詢技術服務
  
客服熱線:400-901-9800  客服QQ:4009019800  技術答疑  技術支持  質量反饋  關于我們  聯系我們
亚洲91中文字幕无线码三区,一级片九九,久久福利小视频
首頁 > 產品中心 > 標記一抗 > 產品信息
Rabbit Anti-VRK1/Cy5.5 Conjugated antibody (bs-7706R-Cy5.5)
訂購熱線:400-901-9800
訂購郵箱:sales@bioss.com.cn
訂購QQ:  400-901-9800
技術支持:techsupport@bioss.com.cn
說 明 書: 100ul  
100ul/2980.00元
大包裝/詢價
產品編號 bs-7706R-Cy5.5
英文名稱 Rabbit Anti-VRK1/Cy5.5 Conjugated antibody
中文名稱 Cy5.5標記的牛痘病毒相關激酶1抗體(絲氨酸/蘇氨酸蛋白激酶VRK1)
別    名 PCH1; Serine/threonine protein kinase VRK1; Serine/threonine-protein kinase VRK1; Vaccinia related kinase 1; Vaccinia virus B1R related kinase 1; Vaccinia-related kinase 1; VRK1; VRK1_HUMAN; MGC117401; MGC138280; MGC142070  
規格價格 100ul/2980元 購買        大包裝/詢價
說 明 書 100ul  
研究領域 細胞生物  細胞周期蛋白  轉錄調節因子  激酶和磷酸酶  表觀遺傳學  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應 (predicted: Human, Mouse, Rat, Pig, Cow, Horse, Sheep, )
產品應用 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 45kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human VRK1 (122-165aa)
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產品介紹 background:
This gene encodes a member of the vaccinia-related kinase (VRK) family of serine/threonine protein kinases. This gene is widely expressed in human tissues and has increased expression in actively dividing cells, such as those in testis, thymus, fetal liver, and carcinomas. Its protein localizes to the nucleus and has been shown to promote the stability and nuclear accumulation of a transcriptionally active p53 molecule and, in vitro, to phosphorylate Thr18 of p53 and reduce p53 ubiquitination. This gene, therefore, may regulate cell proliferation. This protein also phosphorylates histone, casein, and the transcription factors ATF2 (activating transcription factor 2) and c-JUN.

Function:
Serine/threonine kinase involved in Golgi disassembly during the cell cycle: following phosphorylation by PLK3 during mitosis, required to induce Golgi fragmentation. Acts by mediating phosphorylation of downstream target protein. Phosphorylates 'Thr-18' of p53/TP53 and may thereby prevent the interaction between p53/TP53 and MDM2. Phosphorylates casein and histone H3. Phosphorylates BANF1: disrupts its ability to bind DNA, reduces its binding to LEM domain-containing proteins and causes its relocalization from the nucleus to the cytoplasm.

Subcellular Location:
Cytoplasm. Nucleus. Cytoplasm, cytoskeleton, spindle (By similarity). Note=Dispersed throughout the cell but not located on mitotic spindle or chromatids during mitosis.

Tissue Specificity:
Widely expressed. Highly expressed in fetal liver, testis and thymus.

Post-translational modifications:
Autophosphorylated at various serine and threonine residues. Autophosphorylation does not impair its ability to phosphorylate p53/TP53. Phosphorylation by PLK3 leads to induction of Golgi fragmentation during mitosis.

DISEASE:
Defects in VRK1 are the cause of pontocerebellar hypoplasia type 1A (PCH1A) [MIM:607596]; also called pontocerebellar hypoplasia with infantile spinal muscular atrophy or pontocerebellar hypoplasia with anterior horn cell disease. PCH1A is characterized by an abnormally small cerebellum and brainstem, central and peripheral motor dysfunction from birth, gliosis and anterior horn cell degeneration resembling infantile spinal muscular atrophy (SMA).

Similarity:
Belongs to the protein kinase superfamily. CK1 Ser/Thr protein kinase family. VRK subfamily.
Contains 1 protein kinase domain.

Database links:
UniProtKB/Swiss-Prot: Q99986.1

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
版權所有 2004-2026 www.kastlife.cn 北京博奧森生物技術有限公司
通過國際質量管理體系ISO 9001:2015 GB/T 19001-2016    證書編號: 00124Q34771R2M/1100
通過國際醫療器械-質量管理體系ISO 13485:2016 GB/T 42061-2022    證書編號: CQC24QY10047R0M/1100
京ICP備05066980號-1         京公網安備110107000727號
主站蜘蛛池模板: 青青草综合视频 | 日本乱妇日本乱妇18 | 国产精品极品美女自在线观看免费 | 国产清纯91天堂在线观看 | 国产性色强伦免费视频 | 久久人人爽人人爽人人爽 | 成人激情视频网站 | 韩国av片女演员 | 国产精品人人爽人人做av片 | 内射巨臀欧美在线视频 | 麻豆视频一区二区三区 | 欧美亚洲精品一区二区在线观看 | 国产亚洲欧洲 | 992tv精品视频tv在线观看 | 国产在线视频福利 | 国产区二| 久久婷婷人人澡人人爽人人爱 | 日韩免费在线 | 国产剧情AV麻豆香蕉精品 | 国产蜜月AⅤ网站 | 最近免费日本视频在线 | 她似遥上月短剧免费观看 | 亚洲中文字幕aⅴ无码天堂 成人黄网视频在线观看 | 蜜桃国内精品久久久久软件9 | 国产成人久久综合777777麻豆 | 亚洲一区二区三区国产精品 | 激烈18禁高潮视频免费 | 成a人v在线观看视频 | 99er视频 | 强公把我次次高潮HD | 久久久精品国产 | 岛国激情av | 免费性av| 日韩中字在线 | 欧美在线一 | 玖色av| 日韩资源在线观看 | 国产九色视频在线观看 | 国内自拍中文字幕 | 亚洲精品久久久久高潮 | 亚洲精品久久久久69影院 |