97久久久精品综合88久久_亚洲国产精品一_久热热国产久热_97操操操_北条麻妃在线免费观看_精品国自产拍天天拍

掃碼關注公眾號           掃碼咨詢技術支持           掃碼咨詢技術服務
  
客服熱線:400-901-9800  客服QQ:4009019800  技術答疑  技術支持  質量反饋  關于我們  聯系我們
日韩大片免费观看视频播放,av在线免费资源,中文在线天堂网
首頁 > 產品中心 > 標記一抗 > 產品信息
Rabbit Anti-VRK1/PE-Cy7 Conjugated antibody (bs-7706R-PE-Cy7)
訂購熱線:400-901-9800
訂購郵箱:sales@bioss.com.cn
訂購QQ:  400-901-9800
技術支持:techsupport@bioss.com.cn
說 明 書: 100ul  
100ul/2980.00元
大包裝/詢價
產品編號 bs-7706R-PE-Cy7
英文名稱 Rabbit Anti-VRK1/PE-Cy7 Conjugated antibody
中文名稱 PE-Cy7標記的牛痘病毒相關激酶1抗體(絲氨酸/蘇氨酸蛋白激酶VRK1)
別    名 PCH1; Serine/threonine protein kinase VRK1; Serine/threonine-protein kinase VRK1; Vaccinia related kinase 1; Vaccinia virus B1R related kinase 1; Vaccinia-related kinase 1; VRK1; VRK1_HUMAN; MGC117401; MGC138280; MGC142070  
規格價格 100ul/2980元 購買        大包裝/詢價
說 明 書 100ul  
研究領域 細胞生物  細胞周期蛋白  轉錄調節因子  激酶和磷酸酶  表觀遺傳學  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應 (predicted: Human, Mouse, Rat, Pig, Cow, Horse, Sheep, )
產品應用 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 45kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human VRK1 (122-165aa)
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產品介紹 background:
This gene encodes a member of the vaccinia-related kinase (VRK) family of serine/threonine protein kinases. This gene is widely expressed in human tissues and has increased expression in actively dividing cells, such as those in testis, thymus, fetal liver, and carcinomas. Its protein localizes to the nucleus and has been shown to promote the stability and nuclear accumulation of a transcriptionally active p53 molecule and, in vitro, to phosphorylate Thr18 of p53 and reduce p53 ubiquitination. This gene, therefore, may regulate cell proliferation. This protein also phosphorylates histone, casein, and the transcription factors ATF2 (activating transcription factor 2) and c-JUN.

Function:
Serine/threonine kinase involved in Golgi disassembly during the cell cycle: following phosphorylation by PLK3 during mitosis, required to induce Golgi fragmentation. Acts by mediating phosphorylation of downstream target protein. Phosphorylates 'Thr-18' of p53/TP53 and may thereby prevent the interaction between p53/TP53 and MDM2. Phosphorylates casein and histone H3. Phosphorylates BANF1: disrupts its ability to bind DNA, reduces its binding to LEM domain-containing proteins and causes its relocalization from the nucleus to the cytoplasm.

Subcellular Location:
Cytoplasm. Nucleus. Cytoplasm, cytoskeleton, spindle (By similarity). Note=Dispersed throughout the cell but not located on mitotic spindle or chromatids during mitosis.

Tissue Specificity:
Widely expressed. Highly expressed in fetal liver, testis and thymus.

Post-translational modifications:
Autophosphorylated at various serine and threonine residues. Autophosphorylation does not impair its ability to phosphorylate p53/TP53. Phosphorylation by PLK3 leads to induction of Golgi fragmentation during mitosis.

DISEASE:
Defects in VRK1 are the cause of pontocerebellar hypoplasia type 1A (PCH1A) [MIM:607596]; also called pontocerebellar hypoplasia with infantile spinal muscular atrophy or pontocerebellar hypoplasia with anterior horn cell disease. PCH1A is characterized by an abnormally small cerebellum and brainstem, central and peripheral motor dysfunction from birth, gliosis and anterior horn cell degeneration resembling infantile spinal muscular atrophy (SMA).

Similarity:
Belongs to the protein kinase superfamily. CK1 Ser/Thr protein kinase family. VRK subfamily.
Contains 1 protein kinase domain.

Database links:
UniProtKB/Swiss-Prot: Q99986.1

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
版權所有 2004-2026 www.kastlife.cn 北京博奧森生物技術有限公司
通過國際質量管理體系ISO 9001:2015 GB/T 19001-2016    證書編號: 00124Q34771R2M/1100
通過國際醫療器械-質量管理體系ISO 13485:2016 GB/T 42061-2022    證書編號: CQC24QY10047R0M/1100
京ICP備05066980號-1         京公網安備110107000727號
主站蜘蛛池模板: 日本在线播放视频 | 日韩人妻无码精品专区综合网 | 91九色婷婷 | 在线观看的黄色 | 美女扒开腿让男人桶爽网站 | 亚洲成AV人片在线观看橙子 | 孕妇奶水仑乱A级毛片免费看 | 最新亚洲人成无码WWW | 日韩久久无码免费看A | 国产一区免费在线观看 | 中文无码一区二区视频在线播放 | 九九热线视频只有这里最精品 | 高中生高潮抽搐喷出白浆视频 | 亚洲AV久久久噜噜噜熟女软件 | 久久狠狠色噜噜狠狠狠狠97 | 麻豆福利视频 | 亚洲人成网站在小说 | 久久精品色播 | 我和亲妺妺乱的性视频 | ye321夜色资源最新地址 | 扒开粉嫩小泬舌头伸进去视频 | 亚洲精选免费 | 亚洲欧美日韩在线 | 中文字幕中文字幕在线中文字幕三区 | 天天插天天爱 | 麻豆视频网页 | 00271最新网站地址一 | 精品国产免费一区二区三区四区 | 国产伦一区二区三区视频 | 中文无码久久精品 | 精品日韩卡1二2卡3卡4卡乱码 | 久久久国产一区二区 | 亚洲一道本 | www.51色.com| 免费观看一级大片 | 亚洲成av人片在线观看无码不卡 | 好爽好大久久久级淫片毛片小说 | 欧美精品一二区 | 亚洲人午夜精品免费 | 综合亚洲自拍 | 最新永久无码AV网址亚洲 |