97久久久精品综合88久久_亚洲国产精品一_久热热国产久热_97操操操_北条麻妃在线免费观看_精品国自产拍天天拍

掃碼關注公眾號           掃碼咨詢技術支持           掃碼咨詢技術服務
  
客服熱線:400-901-9800  客服QQ:4009019800  技術答疑  技術支持  質量反饋  關于我們  聯系我們
性爱在线免费视频,av手机网,精品午夜福利无人区乱码一区
首頁 > 產品中心 > 標記一抗 > 產品信息
Rabbit Anti-CDCA5/APC Conjugated antibody (bs-7717R-APC)
訂購熱線:400-901-9800
訂購郵箱:sales@bioss.com.cn
訂購QQ:  400-901-9800
技術支持:techsupport@bioss.com.cn
說 明 書: 100ul  
100ul/2980.00元
大包裝/詢價
產品編號 bs-7717R-APC
英文名稱 Rabbit Anti-CDCA5/APC Conjugated antibody
中文名稱 APC標記的細胞分裂周期相關蛋白5抗體
別    名 Cell division cycle associated protein 5; MGC16386; p35; Sororin; CDCA5_HUMAN.  
規格價格 100ul/2980元 購買        大包裝/詢價
說 明 書 100ul  
研究領域 細胞生物  染色質和核信號  細胞周期蛋白  細胞分化  表觀遺傳學  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應 Human, Mouse,  (predicted: Rat, Dog, Pig, Cow, Horse, Rabbit, )
產品應用 Flow-Cyt=1:50-200 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 28kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human CDCA5
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產品介紹 background:
Sororin, also designated cell division cycle-associated protein 5 (CDCA5) or p35, functions as a regulator of sister chromatid cohesion during mitosis. It interacts with the APC/C complex and is found in a complex consisting of cohesion components SCC-112, MC1L1, SMC3L1, RAD21 and APRIN. The deduced human and mouse Sororin proteins consist of 252 and 264 amino acid residues, respectively, and both contain a KEN box for APC-dependent ubiquitination. Reserach demonstrates a punctated nuclear distribution of Sororin during interphase and a diffuse distribution throughout the cell during mitosis. There is no apparent concentration of Sororin on chromatin in mitotic cells and Sororin levels decrease in synchronized HeLa cells during interphase. The Sororin gene maps to chromosome 11q12.1.

Function:
CDCA5 is a regulator of sister chromatid cohesion in mitosis. It may act by regulating the ability of the cohesin complex to mediate sister chromatid cohesion, perhaps by altering the nature of the interaction of cohesin with the chromosomes. CDCA5 interacts with the APC/C complex and is found in a complex with the cohesin components SMC1L1, SMC3L1, RAD21, PDS5A/APRIN and PDS5B/SCC-112.

Subunit:
Interacts with the APC/C complex (By similarity). Interacts with the chromatin-bound cohesin complex; the interaction is indirect, occurs after DNA replication and requires acetylation of the cohesin component SMC3. Interacts (via the FGF motif) with PDS5A and PDS5B; the interaction is direct and prevents the interaction of PDS5A with WAPAL.

Subcellular Location:
Nuclear.

Post-translational modifications:
Phosphorylated. Phosphorylation, as cells enter mitosis, disrupts the interaction with PDS5A and relieves the inhibition of WAPAL by CDCA5.
Ubiquitinated by the APC/C complex in G1, leading to its degradation (Probable).

Similarity:
Belongs to the sororin family.

Database links:
UniProtKB/Swiss-Prot: Q96FF9.1

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
版權所有 2004-2026 www.kastlife.cn 北京博奧森生物技術有限公司
通過國際質量管理體系ISO 9001:2015 GB/T 19001-2016    證書編號: 00124Q34771R2M/1100
通過國際醫療器械-質量管理體系ISO 13485:2016 GB/T 42061-2022    證書編號: CQC24QY10047R0M/1100
京ICP備05066980號-1         京公網安備110107000727號
主站蜘蛛池模板: 精品无码AV无码专区 | 这里只有精品在线观看 | 在线观看国产成人av天堂 | 中文字幕日韩一级 | 国产日产欧产美韩毛毛片 | 亚洲国产精品综合小说图片区 | 亚洲国产亚洲 | 高清国产午夜精品久久久久久 | 国产成人一区二区在线观看 | 黄色欧美日韩 | 精品国产一区二区三区麻豆小说 | 成人av专区 | 99精品一级欧美片免费播放资讯 | 国产精品久久久久久久久大全 | 亚洲三区在线观看内射后入 | 在线观看国产一区二区三区 | 国产亚洲综合精品 | 中文字幕无码肉感爆乳在线 | 亚洲一区成人 | 日本中文字幕在线免费观看视频 | 久久精品成人 | 久久精久久 | 色欲精品国产一区二区三区AV | 久久国产精品视频 | 综合色天天鬼久久鬼色 | 亚洲av日韩av永久无码不卡 | 国内精品国产成人国产三级李采潭 | 日本乱子人伦在线视频 | 亚洲一区av在线观看无码 | 久久精品在线 | 亚洲国产精品成人天堂 | 00粉嫩高中生洗澡偷拍视频 | 日本欧美一区二区三区视频麻豆 | 日本在线播放一二三区 | 欧美成人看片一区二区三区尤物 | 久久国产精品精品国产 | 亚洲精品国产精品久久99 | 欧美性猛交XXXX黑人猛交 | 成人影院欧美黄色 | 亚洲精品综合精品自拍 | 2023国产一二三区日本精品2022 |