97久久久精品综合88久久_亚洲国产精品一_久热热国产久热_97操操操_北条麻妃在线免费观看_精品国自产拍天天拍

掃碼關注公眾號           掃碼咨詢技術支持           掃碼咨詢技術服務
  
客服熱線:400-901-9800  客服QQ:4009019800  技術答疑  技術支持  質量反饋  關于我們  聯系我們
在线看国产精品,精品嫩草,cao人人
首頁 > 產品中心 > 標記一抗 > 產品信息
Rabbit Anti-RACGAP1/BF555 Conjugated antibody (bs-7766R-BF555)
訂購熱線:400-901-9800
訂購郵箱:sales@bioss.com.cn
訂購QQ:  400-901-9800
技術支持:techsupport@bioss.com.cn
說 明 書: 100ul  
100ul/2980.00元
大包裝/詢價
產品編號 bs-7766R-BF555
英文名稱 Rabbit Anti-RACGAP1/BF555 Conjugated antibody
中文名稱 BF555標記的Rho GTP酶激活蛋白GAP抗體
別    名 GAP; Gap1; GTPase activating protein; HsCYK 4; HsCYK4; ID GAP; KIAA1478; MgcRacGAP; Rac GTPase activating protein 1; RACGAP 1; RGAP1_HUMAN.  
規格價格 100ul/2980元 購買        大包裝/詢價
說 明 書 100ul  
研究領域 細胞生物  信號轉導  轉錄調節因子  細胞分化  G蛋白信號  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應 (predicted: Human, Mouse, Rat, Dog, Cow, )
產品應用 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 71kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human RACGAP1
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產品介紹 background:
Rho GTPases control a variety of cellular processes. There are 3 subtypes of Rho GTPases in the Ras superfamily of small G proteins: RHO, RAC and CDC42. GTPase-activating proteins (GAPs) bind activated forms of Rho GTPases and stimulate GTP hydrolysis. Through this catalytic function, Rho GAPs negatively regulate Rho-mediated signals. GAPs may also serve as effector molecules and play a role in signaling downstream of Rho and other Ras-like GTPases.

Function:
Component of the centralspindlin complex that serves asa microtubule-dependent and Rho-mediated signaling required for themyosin contractile ring formation during the cell cyclecytokinesis. Plays key roles in controlling cell growth anddifferentiation of hematopoietic cells through mechanisms otherthan regulating Rac GTPase activity. Also involved in theregulation of growth-related processes in adipocytes and myoblasts.May be involved in regulating spermatogenesis and in the RACGAP1pathway in neuronal proliferation. Shows strong GAP (GTPaseactivation) activity towards CDC42 and RAC1 and less towards RHOA.Essential for the early stages of embryogenesis. May play a role inregulating cortical activity through RHOA during cytokinesis. Mayparticipate in the regulation of sulfate transport in male germcells.

Subunit:
Heterotetramer of two molecules each of RACGAP1 andKIF23. Found in the centralspindlin complex composed of RACGAP1 andKIF23. Associates with alpha-, beta- and gamma-tubulin andmicrotubules. Interacts via its Rho-GAP domain with RND2.Associates with AURKB during M phase. Interacts via its Rho-GAPdomain and basic region with PRC1. The interaction with PRC1inhibits its GAP activity towards CDC42 in vitro, which may berequired for maintaining normal spindle morphology. Interacts withSLC26A8 via its N-terminus. Interacts with RAB11FIP3. Interactswith ECT2; the interaction is direct, occurs at anaphase and duringcytokinesis in a microtubule-dependent manner and is enhanced byphosphorylation by PLK1. Interacts with KIF23; the interaction isdirect.

Subcellular Location:
ucleus. Cytoplasm. Cytoplasm, cytoskeleton,spindle. Cytoplasmic vesicle, secretory vesicle, acrosome. Cleavagefurrow. Midbody. Note=Colocalizes with RND2 in Golgi-derivedproacrosomal vesicles and the acrosome (By similarity). Duringinterphase, localized to the nucleus and cytoplasm along withmicrotubules, in anaphase, is redistributed to the central spindleand, in telophase and cytokinesis, to the midbody. Colocalizes withRHOA at the myosin contractile ring during cytokinesis. Colocalizeswith ECT2 to the mitotic spindles during anaphase/metaphase, thecleavage furrow during telophase and at the midbody at the end ofcytokinesis. Colocalizes wit Cdc42 to spindle microtubules fromprometaphase to telophase.

Tissue Specificity:
Highly expressed in testis, thymus andplacenta. Expressed at lower levels in spleen and peripheral bloodlymphocytes. In testis, expression is restricted to germ cells withthe highest levels of expression found in spermatocytes. Expressionis regulated in a cell cycle-dependent manner and peaks during G2/Mphase.

Post-translational modifications:
Phosphorylated at multiple sites in the midbody duringcytokinesis. Phosphorylation by AURKB on Ser-387 at the midbody is,at least in part, responsible for exerting its latent GAP activitytowards RhoA. Phosphorylation on multiple serine residues by PLK1enhances its association with ECT2 and is critical for cleavagefurrow formation.

Similarity:
Contains 1 phorbol-ester/DAG-type zinc finger.
Contains 1 Rho-GAP domain.

Database links:
UniProtKB/Swiss-Prot: Q9H0H5.1

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
版權所有 2004-2026 www.kastlife.cn 北京博奧森生物技術有限公司
通過國際質量管理體系ISO 9001:2015 GB/T 19001-2016    證書編號: 00124Q34771R2M/1100
通過國際醫療器械-質量管理體系ISO 13485:2016 GB/T 42061-2022    證書編號: CQC24QY10047R0M/1100
京ICP備05066980號-1         京公網安備110107000727號
主站蜘蛛池模板: av黄色小说 | 亚洲精品一区二区三区中文字幕 | 免费无码中文A级毛片 | 午夜影皖精品av在线播放 | 国产精品亚洲精品日韩已方 | 天天插夜夜操 | 啪啪网址大全 | 2021国产精品成人免费视频 | 亚洲精品无码一区二区三区 | 影院一区二区 | 国产无套露脸在线观看 | 99精品国产99久久久久久 | 精产国品一二三区 | 骚老师av在线 | 国产精品成人免费视频 | 中文AV伊人AV无码AV狼人 | 日本一区二区免费在线观看 | 男女一边摸一边做爽爽的免费软件 | 国内免费视频成人精品 | 直接观看黄网站免费视频 | 丰满少妇高潮惨叫久久久 | 国产又粗又大又黄AA片爱豆 | 蜜臀色欲AV无码国产精品 | 四虎免看黄 | 一级级黄 | 成人免费高清在线播放 | 国精产品一码一码三MBA | 亚洲第一无码精品立川理惠 | 精品国内二区三区 | 亚洲精品久久久久69影院 | 国产中文区4幕区2023 | 亚洲人av在线影院 | 亚洲国产精品成人久久久 | 色花堂国产精品第一页 | 少妇的肉体AA片免费 | 中文在线www | av免费片| 日韩av最新网址 | 99久RE热视频这里只有精品6 | 国产精品久久久久久免费一级 | 亚洲女同成av人片在线观看 |