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Rabbit Anti-NEK8/PE-Cy5 Conjugated antibody (bs-7815R-PE-Cy5)
訂購熱線:400-901-9800
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說 明 書: 100ul  
100ul/2980.00元
大包裝/詢價
產品編號 bs-7815R-PE-Cy5
英文名稱 Rabbit Anti-NEK8/PE-Cy5 Conjugated antibody
中文名稱 PE-Cy5標記的絲氨酸/蘇氨酸蛋白激酶NEK8抗體
別    名 JCK; NEK 8; NEK12A; NEK8; NEK8_HUMAN; Never in mitosis A-related kinase 8; NIMA-family kinase NEK8; NIMA-related kinase 12a; Nima-related protein kinase 12a; NimA-related protein kinase 8; Serine/threonine-protein kinase Nek8.  
規格價格 100ul/2980元 購買        大包裝/詢價
說 明 書 100ul  
研究領域 細胞生物  細胞周期蛋白  激酶和磷酸酶  表觀遺傳學  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應 (predicted: Human, Mouse, Rat, Chicken, Dog, Cow, )
產品應用 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 75kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human NEK8
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產品介紹 background:
Required for renal tubular integrity.
Tissue specificity: Highest expression in thyroid, adrenal gland and skin. Low levels in spleen, colon and uterus. Overexpressed in breast tumors, with highest expression in infiltrating ductal carcinomas and moderate levels in mucinous adenocarcinoma.

Function:
Required for renal tubular integrity. May regulate localcytoskeletal structure in kidney tubule epithelial cells. Mayregulate ciliary biogenesis through targeting of proteins to thecilia (By similarity).

Subunit:
Interacts with PKD2; may regulate PKD2 targeting to thecilium (By similarity).

Subcellular Location:
Cytoplasm (By similarity). Cytoplasm,cytoskeleton. Cell projection, cilium (By similarity).Note=Predominantly cytoplasmic. Localizes to the proximal region ofthe primary cilium and is not observed in dividing cells.

Tissue Specificity:
Highest expression in thyroid, adrenal glandand skin. Low levels in spleen, colon and uterus. Overexpressed inbreast tumors, with highest expression in infiltrating ductalcarcinomas and moderate levels in mucinous adenocarcinoma.

DISEASE:
Defects in NEK8 are the cause of nephronophthisis type 9(NPHP9) [MIM:613824]. NPHP9 is an autosomal recessive disorderresulting in end-stage renal disease. It is a progressivetubulo-interstitial kidney disorder histologically characterized bymodifications of the tubules with thickening of the basementmembrane, interstitial fibrosis and, in the advanced stages,medullary cysts.

Similarity:
Belongs to the protein kinase superfamily. NEK Ser/Thrprotein kinase family. NIMA subfamily.
Contains 1 protein kinase domain.
Contains 5 RCC1 repeats.

Database links:
UniProtKB/Swiss-Prot: Q86SG6.1

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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