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Rabbit Anti-phospho-NUDC(Ser326)/APC Conjugated antibody (bs-7842R-APC)
訂購熱線:400-901-9800
訂購郵箱:sales@bioss.com.cn
訂購QQ:  400-901-9800
技術支持:techsupport@bioss.com.cn
說 明 書: 100ul  
100ul/2980.00元
大包裝/詢價
產品編號 bs-7842R-APC
英文名稱 Rabbit Anti-phospho-NUDC(Ser326)/APC Conjugated antibody
中文名稱 APC標記的磷酸化細胞核分離基因C蛋白抗體
別    名 NUDC (phospho S326); NUDC (phospho Ser326); p-NUDC(S326); p-NUDC(Ser326); HNUDC; MNUDC; MNUDC protein; NPD011; Nuclear distribution gene C (A.nidulans) homolog; Nuclear distribution gene C homolog; Nuclear distribution gene C homolog (A. nidulans); Nuclear distribution protein C homolog; Nuclear migration protein nudC; nudC; NUDC_HUMAN; OTTHUMP00000004405; SIG 92; SIG92.  
規格價格 100ul/2980元 購買        大包裝/詢價
說 明 書 100ul  
產品類型 磷酸化抗體 
研究領域 腫瘤  細胞生物  神經生物學  細胞周期蛋白  細胞分化  表觀遺傳學  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應 (predicted: Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, )
產品應用 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 38kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthesised phosphopeptide derived from human NUDC around the phosphorylation site of Ser326
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產品介紹 background:
This gene encodes a nuclear distribution protein that plays an essential role in mitosis and cytokinesis. The encoded protein is involved in spindle formation during mitosis and in microtubule organization during cytokinesis. Pseudogenes of this gene are found on chromosome 2. [provided by RefSeq, Feb 2012].

Function:
Plays a role in neurogenesis and neuronal migration (By similarity). Necessary for correct formation of mitotic spindles and chromosome separation during mitosis. Necessary for cytokinesis and cell proliferation.

Subunit:
Binds PLK1. Binds PAFAH1B1 (By similarity). Part of a complex containing PLK1, NUDC, dynein and dynactin.

Subcellular Location:
Cytoplasm, cytoskeleton. Nucleus. Note=In a filamentous pattern adjacent to the nucleus of migrating cerebellar granule cells. Colocalizes with tubulin and dynein and with the microtubule organizing center. Distributed throughout the cytoplasm of non-migrating cells. A small proportion is nuclear, in a punctate pattern.

Tissue Specificity:
Ubiquitous. Highly expressed in fetal liver, kidney, lung and brain. Highly expressed in adult pancreas, kidney, skeletal muscle, liver, lung, placenta, prostate, brain and heart.

Post-translational modifications:
Reversibly phosphorylated on serine residues during the M phase of the cell cycle. Phosphorylation on Ser-274 and Ser-326 is necessary for correct formation of mitotic spindles and chromosome separation during mitosis. Phosphorylated by PLK and other kinases.

Similarity:
Belongs to the nudC family.
Contains 1 CS domain.

Database links:

Entrez Gene: 10726 Human

Entrez Gene: 18221 Mouse

Entrez Gene: 29648 Rat

Omim: 610325 Human

SwissProt: Q9Y266 Human

SwissProt: O35685 Mouse

SwissProt: Q63525 Rat

Unigene: 263812 Human

Unigene: 69 Mouse

Unigene: 10413 Rat

NCBI Reference Sequence: NP_006591.1
UniProtKB/Swiss-Prot: Q9Y266.1



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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