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Rabbit Anti-GSK3B interacting protein/Ninein/BF647 Conjugated antibody (bs-7844R-BF647)
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說 明 書: 100ul  
100ul/2980.00元
大包裝/詢價(jià)
產(chǎn)品編號(hào) bs-7844R-BF647
英文名稱 Rabbit Anti-GSK3B interacting protein/Ninein/BF647 Conjugated antibody
中文名稱 BF647標(biāo)記的GSK3B相互作用蛋白抗體
別    名 Centrosome Marker; Centrosome Marker; Glycogen synthase kinase 3 beta interacting protein; Centrosome Marker; Glycogen synthase kinase 3 beta interacting protein; GSK3B interacting protein; h Glycogen synthase kinase 3 beta-interacting protein; hNinein; KIAA1565; NIN; NIN protein; NIN_HUMAN; ninein (GSK3B interacting protein); Ninein; Ninein centrosomal protein; SCKL7.  
規(guī)格價(jià)格 100ul/2980元 購買        大包裝/詢價(jià)
說 明 書 100ul  
研究領(lǐng)域 細(xì)胞生物  信號(hào)轉(zhuǎn)導(dǎo)  細(xì)胞周期蛋白  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) (predicted: Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit, )
產(chǎn)品應(yīng)用 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 243kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human Ninein
亞    型 IgG
純化方法 affinity purified by Protein A
儲(chǔ) 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產(chǎn)品介紹 background:
Ninein is a centrosomal protein required for the positioning and anchorage of the microtubule minus-end in epithelial cells. It may also be a centrosome maturation factor and may be involved in microtubule nucleation. Ninein is a component of the core centrosome and is arranged in a tubular shape with an open and a closed end.

Function:
Centrosomal protein required in the positioning and anchorage of the microtubule minus-end in epithelial cells. May also act as a centrosome maturation factor. May play a role in microtubule nucleation. Overexpression does not perturb nucleation or elongation of microtubules but suppresses release of microtubules.

Subunit:
Homooligomer. Interacts with GSK3B (GSK3-beta) via its C-terminus domain. Interacts with C14ORF166, such interaction may prevent its phosphorylation by GSK3-beta.

Subcellular Location:
Cytoplasm, cytoskeleton, centrosome.

Tissue Specificity:
Ubiquitous. Highly expressed in heart and skeletal muscle. Isoform 1 is more expressed than isoform 5.

Post-translational modifications:
Phosphorylated by Aurora A (AIK) and PKA kinases but not CK2 or Aurora B (AIM). Phosphorylated upon DNA damage, probably by ATM or ATR.

Similarity:
Contains 5 EF-hand domains.

Database links:

Entrez Gene: 51199 Human

Entrez Gene: 18080 Mouse

Omim: 608684 Human

SwissProt: Q8N4C6 Human

SwissProt: Q61043 Mouse

Unigene: 310429 Human

Unigene: 569387 Human

Unigene: 244047 Mouse



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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