97久久久精品综合88久久_亚洲国产精品一_久热热国产久热_97操操操_北条麻妃在线免费观看_精品国自产拍天天拍

掃碼關注公眾號           掃碼咨詢技術支持           掃碼咨詢技術服務
  
客服熱線:400-901-9800  客服QQ:4009019800  技術答疑  技術支持  質量反饋  關于我們  聯系我們
成人资源在线,一本大道道香蕉a,日本视频网站WWW色高清免费
首頁 > 產品中心 > 標記一抗 > 產品信息
Rabbit Anti-SUPT16H/BF594 Conjugated antibody (bs-7879R-BF594)
訂購熱線:400-901-9800
訂購郵箱:sales@bioss.com.cn
訂購QQ:  400-901-9800
技術支持:techsupport@bioss.com.cn
說 明 書: 100ul  
100ul/2980.00元
大包裝/詢價
產品編號 bs-7879R-BF594
英文名稱 Rabbit Anti-SUPT16H/BF594 Conjugated antibody
中文名稱 BF594標記的染色體特異性轉錄延伸因子抗體
別    名 CDC68; Chromatin specific transcription elongation factor 140 kDa subunit; Chromatin-specific transcription elongation factor 140 kDa subunit; Facilitates chromatin transcription complex subunit SPT16; FACT 140 kDa subunit; FACT; FACT complex subunit SPT16; FACTP140; FLJ10857; FLJ14010; hSPT16; SP16H_HUMAN; Suppressor of Ty 16 homolog; Supt16h.  
規格價格 100ul/2980元 購買        大包裝/詢價
說 明 書 100ul  
研究領域 細胞生物  信號轉導  細胞周期蛋白  轉錄調節因子  細胞分化  表觀遺傳學  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應 Mouse,  (predicted: Human, Rat, Dog, Pig, Cow, Horse, Rabbit, Zebrafish, )
產品應用 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 120kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human SUPT16H/CDC68
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產品介紹 background:
Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment of the nucleosome following the passage of RNA polymerase II. The FACT complex is probably also involved in phosphorylation of 'Ser-392' of p53/TP53 via its association with CK2 (casein kinase II). Also involved in vitamin D-coupled transcription regulation via its association with the WINAC complex, a chromatin-remodeling complex recruited by vitamin D receptor (VDR), which is required for the ligand-bound VDR-mediated transrepression of the CYP27B1 gene.

Function:
Component of the FACT complex, a general chromatinfactor that acts to reorganize nucleosomes. The FACT complex isinvolved in multiple processes that require DNA as a template suchas mRNA elongation, DNA replication and DNA repair. Duringtranscription elongation the FACT complex acts as a histonechaperone that both destabilizes and restores nucleosomalstructure. It facilitates the passage of RNA polymerase II andtranscription by promoting the dissociation of one histone H2A-H2Bdimer from the nucleosome, then subsequently promotes thereestablishment of the nucleosome following the passage of RNApolymerase II. The FACT complex is probably also involved inphosphorylation of 'Ser-392' of p53/TP53 via its association withCK2 (casein kinase II). Also involved in vitamin D-coupledtranscription regulation via its association with the WINACcomplex, a chromatin-remodeling complex recruited by vitamin Dreceptor (VDR), which is required for the ligand-bound VDR-mediatedtransrepression of the CYP27B1 gene (By similarity).

Subunit:
Component of the FACT complex, a stable heterodimer ofSSRP1 and SUPT16H. Also component of a CK2-SPT16-SSRP1 complexwhich forms following UV irradiation, composed of SSRP1, SUPT16H,CSNK2A1, CSNK2A2 and CSNK2B. Component of the WINAC complex, atleast composed of SMARCA2, SMARCA4, SMARCB1, SMARCC1, SMARCC2,SMARCD1, SMARCE1, ACTL6A, BAZ1B/WSTF, ARID1A, SUPT16H, CHAF1A andTOP2B. Interacts with NEK9. Binds to histone H2A-H2B. Interactswith GTF2E2.

Subcellular Location:
Nucleus. Chromosome. Note=Colocalizes withRNA polymerase II on chromatin. Recruited to actively transcribedloci.

Tissue Specificity:
Ubiquitous.

Post-translational modifications:
ADP-ribosylated. ADP-ribosylation by PARP1 is induced bygenotoxic stress and correlates with dissociation of FACT fromchromatin.

Similarity:
Belongs to the peptidase M24 family. SPT16 subfamily.

Database links:

Entrez Gene: 514989 Cow

Entrez Gene: 612874 Dog

Entrez Gene: 11198 Human

Entrez Gene: 114741 Mouse

Entrez Gene: 305851 Rat

Omim: 605012 Human

SwissProt: E1BNP8 Cow

SwissProt: Q9Y5B9 Human

SwissProt: Q920B9 Mouse

Unigene: 213724 Human

Unigene: 21662 Mouse

Unigene: 93187 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
版權所有 2004-2026 www.kastlife.cn 北京博奧森生物技術有限公司
通過國際質量管理體系ISO 9001:2015 GB/T 19001-2016    證書編號: 00124Q34771R2M/1100
通過國際醫療器械-質量管理體系ISO 13485:2016 GB/T 42061-2022    證書編號: CQC24QY10047R0M/1100
京ICP備05066980號-1         京公網安備110107000727號
主站蜘蛛池模板: 亚洲爆乳成AV人在线视水卜 | 国产福利一区二区三区在线视频 | 成人欧美大片免费观看 | 日本一级待黄大片 | 亚洲精品无码久久久久秋霞 | 恋爱的味道1在线 | 亚洲欧美日韩国产综合在线 | 蜜桃视频在线观看一区 | 国产精品国产三级国产av品爱网 | 日韩AV一中美AV一中文字慕 | 久久久久久免费免费 | 亚洲中文字幕久久精品蜜桃 | 国产精品av无码毛片久久 | 2023国精产品一二二线免费 | 久久艹av | 国产性xxxx18免费观看视频 | 国产无区一区二区三麻豆 | 欧美一区黄色 | 成人免费高清在线播放 | 4hu44四虎www在线影院麻豆 | 黑人巨茎大战欧美白妇 | 人人澡人人曰人人摸看 | av在线h | 青青草综合在线 | 蜜桃传媒一区二区 | 久草在线观看首页 | 欧美亚洲系列 | 中文字幕永久视频 | 好大好爽好深国产在线 | 成人在线观看不卡 | 无码精品人妻免费 | 欧美亚洲精品一区二区在线观看 | 性深夜免费福利视频 | 国产成人久久久精品二区三区 | 欧美一级鲁丝片 | 56精品视频在线播放免费观看 | 国产精品久久久久无码av | 成本人在线观看视频网站 | 柠檬福利第一导航在线 | 久久久久久久久久久久久久久久久久久 | 麻豆网站在线播放 |