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Rabbit Anti-KBTBD10/BF350 Conjugated antibody (bs-8044R-BF350)
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說 明 書: 100ul  
100ul/2980.00元
大包裝/詢價
產品編號 bs-8044R-BF350
英文名稱 Rabbit Anti-KBTBD10/BF350 Conjugated antibody
中文名稱 BF350標記的BTB-kelch蛋白家族10抗體
別    名 cb52; fb24f05; fc15e07; Gm112; KBTBD10; Kel like protein 23; Kelch related protein 1; KRP1; MGC143407; Sarcosin; sbcb52; wufb24f05; wufc15e07; KBTBA_HUMAN.  
規格價格 100ul/2980元 購買        大包裝/詢價
說 明 書 100ul  
研究領域 心血管  細胞生物  發育生物學  信號轉導  細胞凋亡  轉錄調節因子  細胞骨架  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應 (predicted: Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit, Sheep, )
產品應用 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 68kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human KBTBD10
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產品介紹 background:
Sarcosin contains 1 BTB (POZ) domain and is required for pseudopod elongation in transformed cells. Sarcosin mRNA is up-regulated by less than two folds in the heart in human patients with HCM.

Function:
Required for pseudopod elongation in transformed cells. Substrate-specific adapter of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.

Subunit:
Interacts with NRAP (By similarity). Part of a complex that contains CUL3, RBX1 and KBTBD10.

Subcellular Location:
Cytoplasm. Cytoplasm, cytoskeleton. Cell projection, pseudopodium. Cell projection, ruffle. Note=Predominantly cytoplasmic but can co-localize with F-actin at the membrane ruffle-like structures at the tips of transformation-specific pseudopodia.

Post-translational modifications:
Ubiquitinated and probably targeted for proteasome-independent degradation.

Similarity:
Contains 1 BTB (POZ) domain.
Contains 5 Kelch repeats.

Database links:
UniProtKB/Swiss-Prot: O60662.2

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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