97久久久精品综合88久久_亚洲国产精品一_久热热国产久热_97操操操_北条麻妃在线免费观看_精品国自产拍天天拍

掃碼關注公眾號           掃碼咨詢技術支持           掃碼咨詢技術服務
  
客服熱線:400-901-9800  客服QQ:4009019800  技術答疑  技術支持  質量反饋  關于我們  聯系我們
性高朝久久久久久久3小时,综合激情欧美,91视频精品一区
首頁 > 產品中心 > 標記一抗 > 產品信息
Rabbit Anti-G protein beta subunit like/Biotin Conjugated antibody (bs-8161R-Bio)
訂購熱線:400-901-9800
訂購郵箱:sales@bioss.com.cn
訂購QQ:  400-901-9800
技術支持:techsupport@bioss.com.cn
說 明 書: 100ul  
100ul/2980.00元
大包裝/詢價
產品編號 bs-8161R-Bio
英文名稱 Rabbit Anti-G protein beta subunit like/Biotin Conjugated antibody
中文名稱 生物素標記的G蛋白β樣蛋白抗體
別    名 G protein beta subunit like; G protein beta subunit-like; Gable; GBL; GBL protein; LST8_HUMAN; Mammalian lethal with SEC13 protein 8; MGC111011; mLST8; Protein GbetaL; Target of rapamycin complex subunit LST8; TORC subunit LST8.  
規格價格 100ul/2980元 購買        大包裝/詢價
說 明 書 100ul  
研究領域 細胞生物  免疫學  G蛋白偶聯受體  表觀遺傳學  G蛋白信號  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應 Rat,  (predicted: Human, Mouse, Dog, Pig, Cow, Sheep, )
產品應用 ELISA=1:100-1000 IHC-P=1:50-200 IHC-F=1:50-200 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 36kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human G protein beta subunit like
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產品介紹 background:
Subunit of both mTORC1 and mTORC2, which regulates cell growth and survival in response to nutrient and hormonal signals. mTORC1 is activated in response to growth factors or amino-acids. Growth factor-stimulated mTORC1 activation involves a AKT1-mediated phosphorylation of TSC1-TSC2, which leads to the activation of the RHEB GTPase that potently activates the protein kinase activity of mTORC1. Amino-acid-signaling to mTORC1 requires its relocalization to the lysosomes mediated by the Ragulator complex and the Rag GTPases. Activated mTORC1 up-regulates protein synthesis by phosphorylating key regulators of mRNA translation and ribosome synthesis. mTORC1 phosphorylates EIF4EBP1 and releases it from inhibiting the elongation initiation factor 4E (eiF4E). mTORC1 phosphorylates and activates S6K1 at 'Thr-389', which then promotes protein synthesis by phosphorylating PDCD4 and targeting it for degradation.
Tissue specificity:Broadly expressed, with highest levels in skeletal muscle, heart and kidney.

Function:
Subunit of both mTORC1 and mTORC2, which regulates cell growth and survival in response to nutrient and hormonal signals. mTORC1 is activated in response to growth factors or amino-acids. Growth factor-stimulated mTORC1 activation involves a AKT1-mediated phosphorylation of TSC1-TSC2, which leads to the activation of the RHEB GTPase that potently activates the protein kinase activity of mTORC1. Amino-acid-signaling to mTORC1 requires its relocalization to the lysosomes mediated by the Ragulator complex and the Rag GTPases. Activated mTORC1 up-regulates protein synthesis by phosphorylating key regulators of mRNA translation and ribosome synthesis. mTORC1 phosphorylates EIF4EBP1 and releases it from inhibiting the elongation initiation factor 4E (eiF4E). mTORC1 phosphorylates and activates S6K1 at 'Thr-389', which then promotes protein synthesis by phosphorylating PDCD4 and targeting it for degradation. Within mTORC1, LST8 interacts directly with MTOR and enhances its kinase activity. In nutrient-poor conditions, stabilizes the MTOR-RPTOR interaction and favors RPTOR-mediated inhibition of MTOR activity. mTORC2 is also activated by growth factors, but seems to be nutrient-insensitive. mTORC2 seems to function upstream of Rho GTPases to regulate the actin cytoskeleton, probably by activating one or more Rho-type guanine nucleotide exchange factors. mTORC2 promotes the serum-induced formation of stress-fibers or F-actin. mTORC2 plays a critical role in AKT1 'Ser-473' phosphorylation, which may facilitate the phosphorylation of the activation loop of AKT1 on 'Thr-308' by PDK1 which is a prerequisite for full activation. mTORC2 regulates the phosphorylation of SGK1 at 'Ser-422'. mTORC2 also modulates the phosphorylation of PRKCA on 'Ser-657'.

Subunit:
Part of the mammalian target of rapamycin complex 1 (mTORC1) which contains MTOR, MLST8, RPTOR, AKT1S1/PRAS40 and DEPTOR. mTORC1 binds to and is inhibited by FKBP12-rapamycin. Part of the mammalian target of rapamycin complex 2 (mTORC2) which contains MTOR, MLST8, PRR5, RICTOR, MAPKAP1 and DEPTOR. Contrary to mTORC1, mTORC2 does not bind to and is not sensitive to FKBP12-rapamycin. Interacts directly with MTOR and RPTOR. Interacts with RHEB.

Subcellular Location:
Cytoplasm.

Tissue Specificity:
Broadly expressed, with highest levels in skeletal muscle, heart and kidney.

Similarity:
Belongs to the WD repeat LST8 family.
Contains 7 WD repeats.

Database links:

Entrez Gene: 64223 Human

Entrez Gene: 56716 Mouse

Entrez Gene: 64226 Rat

Omim: 612190 Human

SwissProt: Q9BVC4 Human

SwissProt: Q9DCJ1 Mouse

SwissProt: Q9Z2K5 Rat

Unigene: 29203 Human

Unigene: 289516 Mouse

Unigene: 9444 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
版權所有 2004-2026 www.kastlife.cn 北京博奧森生物技術有限公司
通過國際質量管理體系ISO 9001:2015 GB/T 19001-2016    證書編號: 00124Q34771R2M/1100
通過國際醫療器械-質量管理體系ISO 13485:2016 GB/T 42061-2022    證書編號: CQC24QY10047R0M/1100
京ICP備05066980號-1         京公網安備110107000727號
主站蜘蛛池模板: 国产大片中文字幕在线观看 | 999视频 | 免费高清一区二区三区 | 91丨porny在线牛牛影视 | 国产永久视频 | 97爱视频 | 天堂约啪 | 久久精品亚洲成在人线av麻豆 | 亚洲看黄| 国语对白嫖老妇胖老太 | 无码丰满熟妇juliaann | av中文在线资源 | 日韩精品99 | 午夜理理伦A级毛片天天看 一区视频免费观看 | 色婷婷综合在线观看 | 正在做饭的少妇中文字幕 | 国产人妻精品无码AV在线 | 欧美一级特黄乱妇高清视频 | 亚洲国产精品ⅴa在线观看 天天看逼 | 久久综合九色综合国产 | 精品无码一区二区的天堂 | 一区二区精品视频 | 日日插夜夜爽 | 久久久久久久人妻无码中文字幕爆 | 亚洲国产AV天码精品果冻传媒 | 狠狠狠的在啪线香蕉亚洲应用 | 久久77| 日99久9在线免费 | 国产剧情一区二区三区 | av免费高清| 亚洲精彩视频在线观看 | 久久99精品久久久噜噜最新章节 | 嘿咻嘿咻免费区在线观看 | 中文字幕在线视频日本 | 无码免费久久国产 | 人妻一本久道久久综合久久鬼色 | 成年人视频在线观看免费 | 色噜噜狠狠色综合网图区 | 中文字幕第9页 | 99re8这里有精品热视频8在线 | 成人在线观看一区二区三区 |