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Rabbit Anti-SHBG/Gold Conjugated antibody (bs-1175R-Gold)
訂購熱線:400-901-9800
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訂購QQ:  400-901-9800
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說 明 書: 100ul(10nm  15nm  35nm
100ul/2980.00元
大包裝/詢價
產品編號 bs-1175R-Gold
英文名稱 Rabbit Anti-SHBG/Gold Conjugated antibody
中文名稱 膠體金標記的性激素結合球蛋白抗體
別    名 Sex Hormone Binding Globulin; ABP; Androgen binding protein; MGC126834; MGC138391; SBP; Sex steroid binding protein; SHBG; TEBG; Testis specific androgen binding protein; Testosterone binding beta globulin; Testosterone Estradiol Binding Globulin; Testosterone estrogen binding globulin; SHBG_HUMAN; Sex hormone-binding globulin; Sex steroid-binding protein; Testis-specific androgen-binding protein; Testosterone-estradiol-binding globulin; TeBG; Testosterone-estrogen-binding globulin.  
規格價格 100ul/2980元 購買        大包裝/詢價
說 明 書 100ul(10nm  15nm  35nm
研究領域 腫瘤  生長因子和激素  結合蛋白  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應 (predicted: Human, Mouse, Rat, Dog, Cow, Rabbit, )
產品應用 IEM=1:20-200 ICA=1:20-200 ChIP=1:20-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 44kDa
性    狀 Lyophilized or Liquid
濃    度 0.4mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human SHBG
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.02M TBS(pH8.2) with 1% BSA, 0.03% Proclin300.
保存條件 Store at 2-8 oC for 3-6 months. Avoid repeated freeze/thaw cycles.
產品介紹 background:
Sex hormone binding globulin (SHBG) is a glycoprotein synthesized by the liver. Circulating androgen and estrogen concentrations influence SHBG synthesis. Elevated testosterone, for example, causes SHBG synthesis to decrease, whereas high estrogen stimulates SHBG production. The regulation of SHBG synthesis, combined with SHBG's higher affinity for testosterone, impacts bioavailable testosterone levels. SHBG binds up to 98 percent of the steroid hormones in the blood including 5a-dihydrotestosterone (DHT), testosterone and androstenediol with particularly high affinity, and estradiol and estrone with slightly lower affinity.

Function:
Functions as an androgen transport protein, but may also be involved in receptor mediated processes. Each dimer binds one molecule of steroid. Specific for 5-alpha-dihydrotestosterone, testosterone, and 17-beta-estradiol. Regulates the plasma metabolic clearance rate of steroid hormones by controlling their plasma concentration.

Subunit:
Homodimer.

Subcellular Location:
Secreted . Note=In testis, it is synthesized by the Sertoli cells, secreted into the lumen of the seminiferous tubule and transported to the epididymis.

Tissue Specificity:
Isoform 1 and isoform 2 are present in liver and testis.

Post-translational modifications:
Variant Asn-356 contains one N-linked (GlcNAc...) at position 356.

Similarity:
Contains 2 laminin G-like domains.

Database links:

Entrez Gene: 404182 Cow

Entrez Gene: 6462 Human

Omim: 182205 Human

SwissProt: P04278 Human

Unigene: 632235 Human



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

性激素結合球蛋白(SHBG),又稱睪酮—雌二醇結合球蛋白。
SHBG是一運輸性激素的載體,它在性激素人作用過程中以及在各種生理病理情況下都有一定的變化和意義。
SHBG是由母體肝臟產生的循環類固醇類結合球蛋白,執行載體蛋白的功能,胰島素是肝臟合成SHBG的強大的抑制因子,胰島素抑制效應的主要作用點在于競爭性刺激肝臟SHBG的產生,因而SHBG減少是高胰島素血癥、胰島素抵抗的標志。
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