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Rabbit Anti-GDNF Receptor alpha 2/PE-Cy7 Conjugated antibody (bs-0054R-PE-Cy7)
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說 明 書: 100ul  
100ul/2980.00元
大包裝/詢價
產品編號 bs-0054R-PE-Cy7
英文名稱 Rabbit Anti-GDNF Receptor alpha 2/PE-Cy7 Conjugated antibody
中文名稱 PE-Cy7標記的膠質細胞系源性神經營養因子受體α2抗體
別    名 GDNF family receptor alpha-2; GDNF Receptor α2; GDNF receptor beta; GDNFR beta; GDNFR-beta; GDNFRB; GFR alpha 2; GFRA 2; GFRA2; GFR alpha-2; Glial cell line derived neurotrophic factor family receptor alpha2b; Glial cell line derived neurotrophic factor receptor beta; Neurturin receptor alpha; NRTNR alpha; NRTNR-alpha; NTNR alpha; NTNR-alpha; NTNRA; PI linked cell surface accessory protein; RET ligand 2; RETL 2; RETL2; TGF beta related neurotrophic factor receptor 2; TRN receptor GPI anchored; TRNR 2; TRNR2; GFRA2_HUMAN; GDNF family receptor alpha-2; GDNF receptor alpha-2; Short=GDNFR-alpha-2; GFR-alpha-2; Neurturin receptor alpha; TGF-beta-related neurotrophic factor receptor 2.  
規格價格 100ul/2980元 購買        大包裝/詢價
說 明 書 100ul  
研究領域 發育生物學  神經生物學  細胞膜受體  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應 (predicted: Human, Mouse, Rat, Chicken, Dog, Cow, Horse, )
產品應用 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 47kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human GDNF Receptor alpha 2
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產品介紹 background:
Glial cell line-derived neurotrophic factor (GDNF) and neurturin (NTN) are two structurally related, potent neurotrophic factors that play key roles in the control of neuron survival and differentiation. The protein encoded by this gene is a member of the GDNF receptor family. It is a glycosylphosphatidylinositol(GPI)-linked cell surface receptor for both GDNF and NTN, and mediates activation of the RET tyrosine kinase receptor. This encoded protein acts preferentially as a receptor for NTN compared to its other family member, GDNF family receptor alpha 1. This gene is a candidate gene for RET-associated diseases. Multiple transcript variants encoding different isoforms have been found for this gene. Members of the glial cell line-derived neurotrophic factor(GDNF) family, including GDNF and neurturin (NTN),play key roles in the control of vertebrate neuron survivaland differentiation. Physiological responses to NTN requirethe presence of a novel glycosylphosphadidylinositollinked protein NTNRa, which is a cell surface receptor forNTN. The cDNAs encoding NTNRa from human, rat,chicken, and mouse have been cloned recently. NTNRa was also termed GDNFRb, Ret ligand 2 (RETL2)or TGF-b-related neurotrophic factor receptor 2 (TrnR2) and nominated as GFRa-2 recently. GFRa-2 binds NTN and mediates activation of RET receptor tyrosine kinase by both NTN and GDNF. Thus, NTN, GFRa-2, and the Ret PTK form a complex to transduce NTN signal andto mediate NTN function.

Function:
Receptor for neurturin. Mediates the NRTN-induced autophosphorylation and activation of the RET receptor. Also able to mediate GDNF signaling through the RET tyrosine kinase receptor.

Subcellular Location:
Cell membrane; Lipid-anchor, GPI-anchor.

Tissue Specificity:
Isoform 1 is found in both brain and placenta.

Similarity:
Belongs to the GDNFR family.

Database links:

Entrez Gene: 2675 Human

Entrez Gene: 14586 Mouse

Entrez Gene: 25136 Rat

Omim: 601956 Human

SwissProt: O00451 Human

SwissProt: O08842 Mouse



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

神經生物學相關蛋白(Neurobiology)
膠質細胞源性神經營養因子(GDNF)是TGF-β家族的一個新亞族,該亞族還有新發現的三個成員:Neurturin(NTN)、Persephin(PSP)和Artemin(ART),它們均不程度地對多巴胺神經元、脊髓前角運動神經元、背根神經節、頸上神經節以及腎等非神經元細胞都具有生長促進作用。研究表明膠質細胞系源性神經營養因子,主要用于PD的研究。
GDNF的受體是多成分的復合物,它是由固定于質膜外層的糖基磷脂酰肌醇(GPI)被稱為GDNFRα和酪氨酸激酶RET蛋白組成。GDNFRα為其配體結合亞單位,而RET則是GDNF的功能性受體亞單位,即GDNF特異地結合于其受體的GDNFRα上,再激活RET的酪氨酸磷酸化傳導其信號,影響細胞的活性,發揮其生物學效應。目前,又克隆出了人與大鼠的GDNFRβ序列,與GDNPRα具有47%的同源性。GDNFRβ mRNA在脊髓、DRG和發育中的周圍神經上也均有表達。
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