97久久久精品综合88久久_亚洲国产精品一_久热热国产久热_97操操操_北条麻妃在线免费观看_精品国自产拍天天拍

掃碼關注公眾號           掃碼咨詢技術支持           掃碼咨詢技術服務
  
客服熱線:400-901-9800  客服QQ:4009019800  技術答疑  技術支持  質量反饋  關于我們  聯系我們
国产在线欧美在线,A级大胆欧美人体大胆666,国产成人精品综合久久久久
首頁 > 產品中心 > 標記一抗 > 產品信息
Rabbit Anti-Nucleolin/C23/PE-Cy3 Conjugated antibody (bs-8536R-PE-Cy3)
訂購熱線:400-901-9800
訂購郵箱:sales@bioss.com.cn
訂購QQ:  400-901-9800
技術支持:techsupport@bioss.com.cn
說 明 書: 100ul  
100ul/2980.00元
大包裝/詢價
產品編號 bs-8536R-PE-Cy3
英文名稱 Rabbit Anti-Nucleolin/C23/PE-Cy3 Conjugated antibody
中文名稱 PE-Cy3標記的核仁蛋白C23抗體
別    名 C23; NCL; Nucl; NUCL_HUMAN; Nucleolin; Protein C23.  
規格價格 100ul/2980元 購買        大包裝/詢價
說 明 書 100ul  
研究領域 細胞生物  染色質和核信號  表觀遺傳學  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應 Human, Rat,  (predicted: Mouse, Dog, Pig, Cow, Horse, )
產品應用 Flow-Cyt=1:50-200 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 76kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human Nucleolin
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產品介紹 background:
Nucleolin is the major nucleolar protein of growing eukaryotic cells. C23 (nucleolin, NCL) is a eukaryotic nucleolar phosphoprotein that influences synthesis and maturation of ribosomes. C23 localizes to dense fibrillar regions of the nucleolus. It contains four RNA binding domains that interact with pre-rRNA during synthesis. C23 can influence RNA processing, ribosomal gene transcription and nucleolar targeting of ribosomal components. It is known to associate with a variety of proteins, including the nucleolar protein B23. Phosphorylation by Cdc2 and casein kinase II causes translocation of C23 from the nucleolus to the cytoplasm. Mitotic phosphorylated forms of Bcl-2 are present in nuclear structures in prophase Hela cells together with C23 and Ki-67. Retinoic acid-induced apoptosis leads to C23 down-regulation and Bcl-2 mRNA instability. C23 binds the human telomerase reverse transcriptase subunit (TERT) through interactions with its RNA binding domain 4 and carboxyl-terminal RGG domain, and this interaction is critical for the nucleolar localization of human TERT.

Function:
Nucleolin is the major nucleolar protein of growing eukaryotic cells. It is found associated with intranucleolar chromatin and pre-ribosomal particles. It induces chromatin decondensation by binding to histone H1. It is thought to play a role in pre-rRNA transcription and ribosome assembly. May play a role in the process of transcriptional elongation. Binds RNA oligonucleotides with 5'-UUAGGG-3' repeats more tightly than the telomeric single-stranded DNA 5'-TTAGGG-3' repeats.

Subunit:
Identified in a mRNP granule complex, at least composed of ACTB, ACTN4, DHX9, ERG, HNRNPA1, HNRNPA2B1, HNRNPAB, HNRNPD, HNRNPL, HNRNPR, HNRNPU, HSPA1, HSPA8, IGF2BP1, ILF2, ILF3, NCBP1, NCL, PABPC1, PABPC4, PABPN1, RPLP0, RPS3, RPS3A, RPS4X, RPS8, RPS9, SYNCRIP, TROVE2, YBX1 and untranslated mRNAs. Interacts with APTX and NSUN2. Component of the SWAP complex that consists of NPM1, NCL/nucleolin, PARP1 and SWAP70. Component of a complex which is at least composed of HTATSF1/Tat-SF1, the P-TEFb complex components CDK9 and CCNT1, RNA polymerase II, SUPT5H, and NCL/nucleolin. Interacts (via RRM1 and C-terminal RRM4/Arg/Gly-rich domains) with TERT; the interaction is important for nucleolar localization of TERT. Interacts with ERBB4. Interacts with GZF1; this interaction is important for nucleolar localization of GZF1. Interacts with NVL.

Subcellular Location:
Nucleus, nucleolus. Cytoplasm. Note=Localized in cytoplasmic mRNP granules containing untranslated mRNAs.

Post-translational modifications:
Some glutamate residues are glycylated by TTLL8. This modification occurs exclusively on glutamate residues and results in a glycine chain on the gamma-carboxyl group (By similarity).

Similarity:
Contains 4 RRM (RNA recognition motif) domains.

Database links:

Entrez Gene: 4691 Human

Entrez Gene: 17975 Mouse

Entrez Gene: 25135 Rat

Omim: 164035 Human

SwissProt: P19338 Human

SwissProt: P09405 Mouse

SwissProt: P13383 Rat

Unigene: 79110 Human

Unigene: 154378 Mouse

Unigene: 474153 Mouse

Unigene: 144561 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
版權所有 2004-2026 www.kastlife.cn 北京博奧森生物技術有限公司
通過國際質量管理體系ISO 9001:2015 GB/T 19001-2016    證書編號: 00124Q34771R2M/1100
通過國際醫療器械-質量管理體系ISO 13485:2016 GB/T 42061-2022    證書編號: CQC24QY10047R0M/1100
京ICP備05066980號-1         京公網安備110107000727號
主站蜘蛛池模板: 60—70sexvideos老少配 | 色偷偷色噜噜狠狠网站久久 | 成在线人AV无码高潮喷水 | 久久精品高清视频 | 被黑人伦流澡到高潮hn小说 | 91精品国产综合久久久亚洲 | 国产在线观看不卡一区二区三区 | 欧美日韩一区二区三区不卡 | 久久久久人妻精品区一三寸 | 无码人妻精一区二区三区 | 麻豆www传媒入口 | 国产精品美女WWW爽爽爽视频 | 欧美日韩一区二 | 亚洲一区二区制服在线 | 国产在线视频福利 | 精品无码日韩国产不卡AV | 国产亚洲第一伦理片在线c 啪啪网址大全 | 亚洲日本成人在线观看 | 91久久丝袜国产露脸动漫 | 国产成人无精品久久久 | 午夜1234 | 一区二区三区四区视频免费观看 | 99精品一级欧美片免费播放资讯 | 在线观看久 | 99在线国内在线视频22 | 久久久久久久久18久久久 | 香蕉久久综合 | 韩国三级大全久久网站 | 日本丰满熟妇乱XXXXX故事 | a级片毛片 | 欧美日韩在线一二三 | 国产91小视频在线观看 | 亚洲AV成人一区二区三区AV | 亚卅在线有码无码免费 | 中国少妇内射XXXXⅩ | 亚洲一区二区三区免费观看 | 日本视频免费 | 成人国产三级 | 国产在线不卡精品网站 | 一本久久A精品一区二区 | 亚洲国产精品成人久久久 |