97久久久精品综合88久久_亚洲国产精品一_久热热国产久热_97操操操_北条麻妃在线免费观看_精品国自产拍天天拍

掃碼關注公眾號           掃碼咨詢技術支持           掃碼咨詢技術服務
  
客服熱線:400-901-9800  客服QQ:4009019800  技術答疑  技術支持  質量反饋  關于我們  聯系我們
寡妇一级毛片视频,成人一级毛片,肉番在线观看
首頁 > 產品中心 > 標記一抗 > 產品信息
Rabbit Anti-STIM1/Cy7 Conjugated antibody (bs-8526R-Cy7)
訂購熱線:400-901-9800
訂購郵箱:sales@bioss.com.cn
訂購QQ:  400-901-9800
技術支持:techsupport@bioss.com.cn
說 明 書: 100ul  
100ul/2980.00元
大包裝/詢價
產品編號 bs-8526R-Cy7
英文名稱 Rabbit Anti-STIM1/Cy7 Conjugated antibody
中文名稱 Cy7標記的基質交感分子1抗體
別    名 GOK; SIM; STIM 1; STIM1; STIM-1; Stim1 stromal interaction molecule 1; STIM1_HUMAN; STIM1L; Stromal interaction molecule 1.  
規格價格 100ul/2980元 購買        大包裝/詢價
說 明 書 100ul  
研究領域 腫瘤  細胞生物  信號轉導  通道蛋白  細胞表面分子  淋巴細胞  t-淋巴細胞  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應 Rat,  (predicted: Human, Mouse, Chicken, Dog, Pig, Cow, Horse, Rabbit, )
產品應用
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 75kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human STIM1
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產品介紹 background:
Plays a role in mediating Ca(2+) influx following depletion of intracellular Ca(2+) stores. Acts as Ca(2+) sensor in the endoplasmic reticulum via its EF-hand domain. Upon Ca(2+) depletion, translocates from the endoplasmic reticulum to the plasma membrane where it activates the Ca(2+) release-activated Ca(2+) (CRAC) channel subunit, TMEM142A/ORAI1.

Function:
Plays a role in mediating store-operated Ca(2+) entry (SOCE), a Ca(2+) influx following depletion of intracellular Ca(2+) stores. Acts as Ca(2+) sensor in the endoplasmic reticulum via its EF-hand domain. Upon Ca(2+) depletion, translocates from the endoplasmic reticulum to the plasma membrane where it activates the Ca(2+) release-activated Ca(2+) (CRAC) channel subunit, TMEM142A/ORAI1.

Subunit:
Forms homooligomers and heterooligomers with STIM2. Interacts with ORAI1. Interacts with MAPRE1; probably required for targeting to the growing microtubule plus ends. Interacts with EFCAB4B/CRACR2A; the interaction is direct and takes place in absence of Ca(2+). Forms a complex with EFCAB4B/CRACR2A and ORAI1 at low concentration of Ca(2+), the complex dissociates at elevated Ca(2+) concentrations. Interacts with TMEM66/SARAF, promoting a slow inactivation of STIM1-dependent SOCE activity, possibly by facilitating the deoligomerization of STIM1.

Subcellular Location:
Cell membrane. Endoplasmic reticulum membrane. Cytoplasm > cytoskeleton. Translocates from the endoplasmic reticulum to the cell membrane in response to a depletion of intracellular calcium. Associated with the microtubule network at the growing distal tip of microtubules.

Tissue Specificity:
Ubiquitously expressed in various human primary cells and tumor cell lines.

Post-translational modifications:
Glycosylation is required for cell surface expression.
Phosphorylated predominantly on Ser residues.

DISEASE:
Defects in STIM1 are the cause of immune dysfunction with T-cell inactivation due to calcium entry defect type 2 (IDTICED2) [MIM:612783]. IDTICED2 is an immune disorder characterized by recurrent infections, impaired T-cell activation and proliferative response, decreased T-cell production of cytokines, lymphadenopathy, and normal lymphocytes counts and serum immunoglobulin levels. Additional features include thrombocytopenia, autoimmune hemolytic anemia, non-progressive myopathy, partial iris hypoplasia, hepatosplenomegaly and defective enamel dentition.

Similarity:
Contains 1 EF-hand domain.
Contains 1 SAM (sterile alpha motif) domain.

Database links:

Entrez Gene: 6786 Human

Entrez Gene: 20866 Mouse

Entrez Gene: 361618 Rat

Omim: 605921 Human

SwissProt: Q13586 Human

SwissProt: P70302 Mouse

SwissProt: P84903 Rat

Unigene: 501735 Human

Unigene: 645 Mouse

Unigene: 106771 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
版權所有 2004-2026 www.kastlife.cn 北京博奧森生物技術有限公司
通過國際質量管理體系ISO 9001:2015 GB/T 19001-2016    證書編號: 00124Q34771R2M/1100
通過國際醫療器械-質量管理體系ISO 13485:2016 GB/T 42061-2022    證書編號: CQC24QY10047R0M/1100
京ICP備05066980號-1         京公網安備110107000727號
主站蜘蛛池模板: 色之久久 | 国产一级特黄高清在线大片 | 国产下药迷晕一区二区三区在线看 | 0855午夜福利 | 玖色av| 在线毛片免费 | 5252aⅴhaose我爱久久 | 成人三级网址 | 麻豆影视国产在线观看 | 精品人伦一区二区三区蜜桃视频 | 国产综合精品一区二区 | 欧美日韩精品一区二区三区四区 | 国产日产欧产美韩毛毛片 | 国产高清无码黄片亚洲大尺度视频 | 老司机精品视频在线 | 亚洲人成无码网站WWW | 少妇搡BBBB搡BBB搡AA | 人成在线免费网站 | 精品欧美亚洲韩国日本久久 | 欧美日韩色网专区 | 久久99蜜桃综合影院免费观看 | 久草在线资源总站 | 九九99无码精品视频在线观看 | 就去色播 | 性淫视频 | 日韩1级 | 精品欧美一区二区中文字幕视频 | 日韩毛片网站 | 欧美18videosex性欧美tube1080 | 久久久69| 国产亚洲精品久久久久久青梅 | 国产电视伦理怡红院在线观看 | 手机在线观看av片 | 中文字幕久精品免费视频 | 麻豆www传媒入口 | 蜜桃久久精品一区二区 | 中文字幕人妻丝袜成熟乱 | 午夜影院免费观看 | 91久久艹| 亚洲国产精品成人天堂 | 精品国产一区二区三区色欲 |