97久久久精品综合88久久_亚洲国产精品一_久热热国产久热_97操操操_北条麻妃在线免费观看_精品国自产拍天天拍

掃碼關注公眾號           掃碼咨詢技術支持           掃碼咨詢技術服務
  
客服熱線:400-901-9800  客服QQ:4009019800  技術答疑  技術支持  質量反饋  關于我們  聯系我們
日本成长影片免费观看,婷婷成人免费视频,成人黄网站片免费视频
首頁 > 產品中心 > 標記一抗 > 產品信息
Rabbit Anti-phospho-CDKN1B (Thr157)/FITC Conjugated antibody (bs-5228R-FITC)
訂購熱線:400-901-9800
訂購郵箱:sales@bioss.com.cn
訂購QQ:  400-901-9800
技術支持:techsupport@bioss.com.cn
說 明 書: 100ul  
100ul/2980.00元
大包裝/詢價
產品編號 bs-5228R-FITC
英文名稱 Rabbit Anti-phospho-CDKN1B (Thr157)/FITC Conjugated antibody
中文名稱 FITC標記的磷酸化P27抗體/周期素依賴激酶抑制劑抗體
別    名 p27 KIP 1 (phospho T157); p-p27 KIP 1 (phospho T157); p27Kip1(Phospho-Thr157); p-p27Kip1(Thr157); p-p27Kip1(T157); CDN1B_HUMAN; AA408329; AI843786; Cdki1b; CDKN 1B; CDKN 4; CDKN1B; CDKN1B; CDKN4; CDKN4; Cyclin Dependent Kinase Inhibitor 1B; Cyclin Dependent Kinase Inhibitor 1B; Cyclin dependent kinase inhibitor p27; Cyclin dependent kinase inhibitor p27; Cyclin-dependent kinase inhibitor 1B (p27, Kip1); Cyclin-dependent kinase inhibitor 1B; Cyclin-dependent kinase inhibitor p27; Cyclin-dependent kinase inhibitor p27 Kip1; KIP 1; KIP1; MEN1B; MEN4; OTTHUMP00000195098; OTTHUMP00000195099; p27; p27 Kip1; P27-like cyclin-dependent kinase inhibitor; P27KIP1.  
規格價格 100ul/2980元 購買        大包裝/詢價
說 明 書 100ul  
產品類型 磷酸化抗體 
研究領域 免疫學  細胞周期蛋白  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應 Human, Mouse,  (predicted: Dog, Pig, Rabbit, Guinea Pig, )
產品應用 Flow-Cyt=1:50-200 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 22kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated Synthesised phosphopeptide derived from human CDKN1B around the phosphorylation site of Thr157 [PA(p-T)DD]
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產品介紹 background:
This gene encodes a cyclin-dependent kinase inhibitor, which shares a limited similarity with CDK inhibitor CDKN1A/p21. The encoded protein binds to and prevents the activation of cyclin E-CDK2 or cyclin D-CDK4 complexes, and thus controls the cell cycle progression at G1. The degradation of this protein, which is triggered by its CDK dependent phosphorylation and subsequent ubiquitination by SCF complexes, is required for the cellular transition from quiescence to the proliferative state. [provided by RefSeq, Jul 2008]

Function:
Important regulator of cell cycle progression. Involved in G1 arrest. Potent inhibitor of cyclin E- and cyclin A-CDK2 complexes. Forms a complex with cyclin type D-CDK4 complexes and is involved in the assembly, stability, and modulation of CCND1-CDK4 complex activation. Acts either as an inhibitor or an activator of cyclin type D-CDK4 complexes depending on its phosphorylation state and/or stoichometry.

Subunit:
Forms a ternary compex with CCNE1/CDK2/CDKN1B.

Subcellular Location:
Nucleus. Cytoplasm. Endosome. Nuclear and cytoplasmic in quiescent cells.

Tissue Specificity:
Expressed in all tissues tested. Highest levels in skeletal muscle, lowest in liver and kidney.

Post-translational modifications:
Phosphorylated; phosphorylation occurs on serine, threonine and tyrosine residues. Phosphorylation on Ser-10 is the major site of phosphorylation in resting cells, takes place at the G(0)-G(1) phase and leads to protein stability. Phosphorylation on other sites is greatly enhanced by mitogens, growth factors, cMYC and in certain cancer cell lines. The phosphorylated form found in the cytoplasm is inactivate. Phosphorylation on Thr-198 is required for interaction with 14-3-3 proteins. Phosphorylation on Thr-187, by CDK2 leads to protein ubiquitination and proteasomal degradation. Tyrosine phosphorylation promotes this process. Phosphorylation by PKB/AKT1 can be suppressed by LY294002, an inhibitor of the catalytic subunit of PI3K. Phosphorylation on Tyr-88 and Tyr-89 has no effect on binding CDK2, but is required for binding CDK4. Dephosphorylated on tyrosine residues by G-CSF.
Ubiquitinated; in the cytoplasm by the KPC complex (composed of RNF123/KPC1 and UBAC1/KPC2) and, in the nucleus, by SCF(SKP2). The latter requires prior phosphorylation on Thr-187. Ubiquitinated; by a TRIM21-containing SCF(SKP2)-like complex; leads to its degradation.

DISEASE:
Defects in CDKN1B are the cause of multiple endocrine neoplasia type 4 (MEN4) . Multiple endocrine neoplasia (MEN) syndromes are inherited cancer syndromes of the thyroid. MEN4 is a MEN-like syndrome with a phenotypic overlap of both MEN1 and MEN2.

Similarity:
Belongs to the CDI family.

Database links:

Entrez Gene: 1027 Human

Entrez Gene: 12576 Mouse

Entrez Gene: 83571 Rat

Omim: 600778 Human

SwissProt: P46527 Human

Unigene: 238990 Human



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

P27蛋白是一種新發現的周期素依賴激酶抑制劑,屬于細胞周期的負性調控因子。P27基因及其產物的異常表達可能與某些腫瘤的發生、發展有著密切的關系。P27蛋白對細胞周期的調控及在腫瘤中發揮著很重要的作用。
版權所有 2004-2026 www.kastlife.cn 北京博奧森生物技術有限公司
通過國際質量管理體系ISO 9001:2015 GB/T 19001-2016    證書編號: 00124Q34771R2M/1100
通過國際醫療器械-質量管理體系ISO 13485:2016 GB/T 42061-2022    證書編號: CQC24QY10047R0M/1100
京ICP備05066980號-1         京公網安備110107000727號
主站蜘蛛池模板: 青青草视频在线观 | 99精品偷拍视频一区二区三区 | 国产9999精品 | 蜜桃臀AV高潮无码 | 国产一区三区三区 | 人妻夜夜添夜夜无码AV | 久久久久亚洲综合 | 性伦欧美刺激片在线观看 | 亚洲日本成人在线观看 | 把女人弄爽特黄a大片777 | 精品91一区二区三区 | 青青草视频4 | 久久精品中文骚妇内射AV | 蜜桃天堂 | 久久亚洲影视 | 中文字幕1区2区 | 大乳妇女99精品免费91 | 综合自拍偷拍 | 久久精品女人毛片国产 | 日韩啪啪免费视频 | 一级色毛片 | 中文国产三级 | 精品久久久久久无码人妻A片 | 色网址在线观看 | 中国一级黄色片子 | 狠狠噜天天噜日日噜视频麻豆 | 国产成人精品微拍视频网址 | 性屋娱乐wwwsex5me | 成人亚洲免费视频 | 亚洲一区欧美一区 | 91精品国产色综合久久不卡蜜臀 | 成人在线播放网站 | 免费观看黃色A一级视频日本 | 成人无码午夜在线观看 | 色片在线观看 | 成人av中文解说水果派在线观看 | 顶级少妇做爰视频在线观看 | 老司机深夜福利在线观看 | 伊人精品成人久久综合软件 | 久久久久久无码AV成人影院 | 欧美日韩视频在线播放 |