97久久久精品综合88久久_亚洲国产精品一_久热热国产久热_97操操操_北条麻妃在线免费观看_精品国自产拍天天拍

掃碼關(guān)注公眾號           掃碼咨詢技術(shù)支持           掃碼咨詢技術(shù)服務(wù)
  
客服熱線:400-901-9800  客服QQ:4009019800  技術(shù)答疑  技術(shù)支持  質(zhì)量反饋  關(guān)于我們  聯(lián)系我們
精品日韩欧美一区,国产又粗又大又黄,久热最新视频
Rabbit Anti-phospho-DOK1(Tyr362)/Cy5 Conjugated antibody (bs-5289R-Cy5)
訂購熱線:400-901-9800
訂購郵箱:sales@bioss.com.cn
訂購QQ:  400-901-9800
技術(shù)支持:techsupport@bioss.com.cn
說 明 書: 100ul  
100ul/2980.00元
大包裝/詢價
產(chǎn)品編號 bs-5289R-Cy5
英文名稱 Rabbit Anti-phospho-DOK1(Tyr362)/Cy5 Conjugated antibody
中文名稱 Cy5標(biāo)記的磷酸化D酪氨酸激酶衰減蛋白1抗體
別    名 DOK1 (phospho Y362); DOK1 (phospho Tyr362); p-DOK1 (phospho Y362); docking protein 1 (downstream of tyrosine kinase 1); Docking protein 1 (p62(dok)) (Downstream of tyrosine kinase 1) (pp62).; docking protein 1 62kD (downstream of tyrosine kinase 1); Docking protein 1 62kD; Docking protein 1 62kD; Docking protein 1; DOK 1; DOK1; DOK-1; DOK1_HUMAN; Downstream of tyrosine kinase 1; p62(dok); P62DOK; pp62; pp62.  
規(guī)格價格 100ul/2980元 購買        大包裝/詢價
說 明 書 100ul  
產(chǎn)品類型 磷酸化抗體 
研究領(lǐng)域 腫瘤  心血管  信號轉(zhuǎn)導(dǎo)  細(xì)胞凋亡  G蛋白偶聯(lián)受體  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) Human,  (predicted: Mouse, Rat, Dog, Pig, Cow, )
產(chǎn)品應(yīng)用 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 62kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated Synthesised phosphopeptide derived from human DOK1 around the phosphorylation site of Tyr362
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產(chǎn)品介紹 background:
Docking protein 1 is constitutively tyrosine phosphorylated in hematopoietic progenitors isolated from chronic myelogenous leukemia (CML) patients in the chronic phase. It may be a critical substrate for p210(bcr/abl), a chimeric protein whose presence is associated with CML. Docking protein 1 contains a putative pleckstrin homology domain at the amino terminus and ten PXXP SH3 recognition motifs. Docking protein 2 binds p120 (RasGAP) from CML cells. It has been postulated to play a role in mitogenic signaling.

Function:
DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK1 appears to be a negative regulator of the insulin signaling pathway. Modulates integrin activation by competing with talin for the same binding site on ITGB3.

Subunit:
Interacts with ABL1 (By similarity). Interacts with RasGAP and INPP5D/SHIP1. Interacts directly with phosphorylated ITGB3.

Subcellular Location:
Isoform 1: Cytoplasm. Isoform 3: Cytoplasm, perinuclear region.

Tissue Specificity:
Expressed in pancreas, heart, leukocyte and spleen. Expressed in both resting and activated peripheral blood T-cells.

Post-translational modifications:
Constitutively tyrosine-phosphorylated. Phosphorylated by TEC. Phosphorylated by LYN.
Phosphorylated on tyrosine residues by the insulin receptor kinase. Results in the negative regulation of the insulin signaling pathway.
Isoform 3 contains a N-acetylmethionine at position 1.

Similarity:
Belongs to the DOK family. Type A subfamily.
Contains 1 IRS-type PTB domain.
Contains 1 PH domain.

Database links:

Entrez Gene: 1796 Human

Entrez Gene: 13448 Mouse

Entrez Gene: 312477 Rat

Omim: 602919 Human

SwissProt: Q99704 Human

SwissProt: P97465 Mouse

SwissProt: Q4QQV2 Rat

Unigene: 103854 Human

Unigene: 156 Mouse

Unigene: 117974 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
版權(quán)所有 2004-2026 www.kastlife.cn 北京博奧森生物技術(shù)有限公司
通過國際質(zhì)量管理體系ISO 9001:2015 GB/T 19001-2016    證書編號: 00124Q34771R2M/1100
通過國際醫(yī)療器械-質(zhì)量管理體系ISO 13485:2016 GB/T 42061-2022    證書編號: CQC24QY10047R0M/1100
京ICP備05066980號-1         京公網(wǎng)安備110107000727號
主站蜘蛛池模板: 精品乱码一区内射人妻无码 | 国产吹潮视频在线观看 | 91精品在线免费视频 | 亚洲人成网站在线观看妞妞网 | 亚洲另类色区欧美日韩图片 | 国产三级久久久 | 亚洲第一天堂影院 | 中文国产一区 | 日韩爱情动作片 | 国产专区免费av无码 | 亚洲欧美一区二区在线观看 | 91精品少妇高潮一区二区三区不卡 | 男女性高爱潮免费网站 | 91人人射| 亚洲国产精品成人无码区 | www.一区二区三区.com | 亚洲精品在线视频免费观看 | 无码熟妇人妻AV在线影片 | 欧美性生交大片 | 国产欧美精品一区二区三区四区 | 亚洲欧洲老熟女AV | 久久综合久久自在自线精品自 | 欧美激情视频一区二区三区免费 | 人摸人人人澡人人超碰手机版 | 午夜影视免费观看 | 天天宗合| 久久久性 | 国产aⅴ无码久久久高潮老头 | 少妇翘臀亚洲精品av图片 | 天码AV无码一区二区三区四区 | 精品爆乳一区二区三区无码AV | 99爱色| 真人插b免费视频播放 | 蜜臀久久精品久久久久久酒店? | 日本波多野结衣在线 | 狠狠色综合欧美激情 | 日本理论中文字幕 | 亚洲一级视频在线观看 | 亚洲欧美国产国产综合一区 | 日日碰狠狠添天天爽超碰97久久 | 四虎精品免费 |