97久久久精品综合88久久_亚洲国产精品一_久热热国产久热_97操操操_北条麻妃在线免费观看_精品国自产拍天天拍

掃碼關注公眾號           掃碼咨詢技術支持           掃碼咨詢技術服務
  
客服熱線:400-901-9800  客服QQ:4009019800  技術答疑  技術支持  質量反饋  關于我們  聯系我們
国产日产一区二区三区久久久久久,51午夜精品视频,香蕉久久久久久久
首頁 > 產品中心 > 標記一抗 > 產品信息
Rabbit Anti-GIT1/PE-Cy3 Conjugated antibody (bs-4110R-PE-Cy3)
訂購熱線:400-901-9800
訂購郵箱:sales@bioss.com.cn
訂購QQ:  400-901-9800
技術支持:techsupport@bioss.com.cn
說 明 書: 100ul  
100ul/2980.00元
大包裝/詢價
產品編號 bs-4110R-PE-Cy3
英文名稱 Rabbit Anti-GIT1/PE-Cy3 Conjugated antibody
中文名稱 PE-Cy3標記的G蛋白偶聯受體激酶相互作用蛋白1抗體
別    名 ARF GAP GIT1; ARF GTPase activating protein GIT1; CAT 1; Cat1; Cool associated and tyrosine phosphorylated protein 1; G protein coupled receptor kinase interactor 1; GRK interacting protein 1.  
規格價格 100ul/2980元 購買        大包裝/詢價
說 明 書 100ul  
研究領域 腫瘤  免疫學  轉錄調節因子  G蛋白偶聯受體  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應 (predicted: Human, Mouse, Rat, Chicken, Pig, Cow, )
產品應用 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 84kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human GIT1
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產品介紹 background:
Heterotrimeric G protein-mediated signal transduction is a dynamically regulated process with the intensity of signal decreasing over time despite the continued presence of the agonist (1,2). G protein-coupled receptor kinases (GRKs) are activated by activated G protein-coupled receptors, and they function to phosphorylate and inactivate cell surface receptors in the heterotrimeric G protein signaling cascade (3,4). GIT1 (for GRK-interactor 1) and GIT2 are GTPase-activating proteins (GAP) for members of the ADP ribosylation factor (ARF) family of small GTP-binding proteins, which are involved in vesicular trafficking (5,6). GIT1 overexpression results in reduced internalization and resensitization of b2-adrenergic receptor, thus reducing b2-adrenergic receptor signaling (5).

Function:
GTPase-activating protein for the ADP ribosylation factor family. May serve as a scaffold to bring together molecules to form signaling modules controlling vesicle trafficking, adhesion and cytoskeletal organization. Increases the speed of cell migration, as well as the size and rate of formation of protrusions, possibly by targeting PAK1 to adhesions and the leading edge of lamellipodia. Sequesters inactive non-tyrosine-phosphorylated paxillin in cytoplasmic complexes.

Subcellular Location:
Cytoplasm. Cycles between at least 3 distinct intracellular compartments, including focal adhesions, cytoplasmic complexes and membrane protrusions. During cell migration, when cells detach, moves from the adhesions into the cytoplasmic complexes towards the leading edge, while, when cells adhere, it is found in vinculin-containing adhesions. Recruitment to adhesions may be mediated by active tyrosine-phosphorylated paxillin.

Post-translational modifications:
Phosphorylated on tyrosine residues by PTK2 and SRC in growing fibroblasts. Tyrosine-phosphorylation is increased following cell spreading on fibronectin, decreased in cells arrested in mitosis and increased in the ensuing G1 phase.

Similarity:
Contains 3 ANK repeats.
Contains 1 Arf-GAP domain.

Database links:

Entrez Gene: 28964 Human

Entrez Gene: 216963 Mouse

Entrez Gene: 83709 Rat

Omim: 608434 Human

SwissProt: Q9Y2X7 Human

SwissProt: Q68FF6 Mouse

SwissProt: Q9Z272 Rat

Unigene: 514051 Human

Unigene: 290182 Mouse

Unigene: 34521 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
版權所有 2004-2026 www.kastlife.cn 北京博奧森生物技術有限公司
通過國際質量管理體系ISO 9001:2015 GB/T 19001-2016    證書編號: 00124Q34771R2M/1100
通過國際醫療器械-質量管理體系ISO 13485:2016 GB/T 42061-2022    證書編號: CQC24QY10047R0M/1100
京ICP備05066980號-1         京公網安備110107000727號
主站蜘蛛池模板: 日韩h网站 | 漂亮人妻被中出中文字幕 | 夜夜操天天射 | 亚洲AV久久无码精品国产 | 91老司机福利在线视频 | 国产麻豆精品久久一二三 | 国内精品免费一区二区2001 | 国产日产久久久久久 | 九歌在线观看 | 99精品热在线在线观看视频 | 国产成人精品无码一区二区 | 成人女人免费毛片 | 天天躁日日躁狠狠躁欧美老妇小说 | 无码人妻精品一区二区三 | 日本一区精品 | a天堂最新资源网址 | 日韩啪啪免费视频 | 国产精品96久久久久久又黄又硬 | 欧美一区1区三区3区公司 | 色爱综合网中文字幕第1页 国产农村妇女毛片精品久久 | 国产美女视频a级做爰色戎 一本久久A精品一区二区 | 国产精品日韩AV在线播放 | 人人妻人人爽人人做夜欢视频九色 | 欧美日韩精品一区二区三区在线观看 | 正在播放露脸一区 | 欧美成人一区二区三区片免费 | 久久精品一区二区三区四区 | 中文字幕乱人伦视频在线 | 亚洲九七 | 成人黄网视频在线观看 | 天天摸日日添狠狠添婷婷 | 亚洲福利在线播放 | av在线干 | 欧美国产日韩在线 | 中文字幕中文字幕在线中文字幕三区 | 国产一区二区在线91 | 国产99久久亚洲综合精品西瓜tv | 亚洲国产成人精品无码区在线观看 | 狠狠色狠狠色很很综合很久久 | 国产一二区av | 色欧美在线视频 |