97久久久精品综合88久久_亚洲国产精品一_久热热国产久热_97操操操_北条麻妃在线免费观看_精品国自产拍天天拍

掃碼關注公眾號           掃碼咨詢技術支持           掃碼咨詢技術服務
  
客服熱線:400-901-9800  客服QQ:4009019800  技術答疑  技術支持  質量反饋  關于我們  聯系我們
欧美亚洲在线观看,国产老熟女91pom,免费成人黄
首頁 > 產品中心 > 標記一抗 > 產品信息
Rabbit Anti-RAD9/Biotin Conjugated antibody (bs-4179R-Bio)
訂購熱線:400-901-9800
訂購郵箱:sales@bioss.com.cn
訂購QQ:  400-901-9800
技術支持:techsupport@bioss.com.cn
說 明 書: 100ul  
100ul/2980.00元
大包裝/詢價
產品編號 bs-4179R-Bio
英文名稱 Rabbit Anti-RAD9/Biotin Conjugated antibody
中文名稱 生物素標記的細胞周期檢查控制蛋白質抗體
別    名 Cell cycle checkpoint control protein; Cell cycle checkpoint control protein RAD9A; DNA repair exonuclease rad9 homolog A; hRAD 9; hRAD9; Rad 9; RAD 9A; RAD9 (S pombe) homolog; RAD9 homolog A; RAD9 homolog; RAD9A; RAD9A_HUMAN.  
規格價格 100ul/2980元 購買        大包裝/詢價
說 明 書 100ul  
研究領域 細胞生物  免疫學  染色質和核信號  信號轉導  細胞凋亡  細胞周期蛋白  轉錄調節因子  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應 (predicted: Human, Mouse, Rat, Chicken, Dog, Pig, Rabbit, )
產品應用 WB=1:50-200 ELISA=1:100-1000 IHC-P=1:50-200 IHC-F=1:50-200 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 43kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human RAD9 (201-300aa)
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產品介紹 background:
This gene product is highly similar to Schizosaccharomyces pombe rad9, a cell cycle checkpoint protein required for cell cycle arrest and DNA damage repair in response to DNA damage. This protein is found to possess 3' to 5' exonuclease activity, which may contribute to its role in sensing and repairing DNA damage. It forms a checkpoint protein complex with RAD1 and HUS1. This complex is recruited by checkpoint protein RAD17 to the sites of DNA damage, which is thought to be important for triggering the checkpoint-signaling cascade. Use of alternative polyA sites has been noted for this gene. [provided by RefSeq].

Function:
Component of the 9-1-1 cell-cycle checkpoint response complex that plays a major role in DNA repair. The 9-1-1 complex is recruited to DNA lesion upon damage by the RAD17-replication factor C (RFC) clamp loader complex. Acts then as a sliding clamp platform on DNA for several proteins involved in long-patch base excision repair (LP-BER). The 9-1-1 complex stimulates DNA polymerase beta (POLB) activity by increasing its affinity for the 3'-OH end of the primer-template and stabilizes POLB to those sites where LP-BER proceeds; endonuclease FEN1 cleavage activity on substrates with double, nick, or gap flaps of distinct sequences and lengths; and DNA ligase I (LIG1) on long-patch base excision repair substrates. The 9-1-1 complex is necessary for the recruitment of RHNO1 to sites of double-stranded breaks (DSB) occurring during the S phase. RAD9A possesses 3'->5' double stranded DNA exonuclease activity. Its phosphorylation by PRKCD may be required for the formation of the 9-1-1 complex.

Subunit:
Component of the toroidal 9-1-1 (RAD9-RAD1-HUS1) complex, composed of RAD9A, RAD1 and HUS1. The 9-1-1 complex associates with LIG1, POLB, FEN1, RAD17, HDAC1, RPA1 and RPA2. The 9-1-1 complex associates with the RAD17-RFC complex. RAD9A interacts with BCL2L1, FEN1, PRKCD, RAD9B, HUS1, RAD1, ABL1, RPA1, ATAD5 and RPA2. Interacts with DNAJC7 and RHNO1.

Subcellular Location:
Nucleus.

Post-translational modifications:
Constitutively phosphorylated on serine and threonine amino acids in absence of DNA damage. Hyperphosphorylated by PRKCD and ABL1 upon DNA damage. Its phosphorylation by PRKCD may be required for the formation of the 9-1-1 complex.

Similarity:
Belongs to the rad9 family.

Database links:

Entrez Gene: 5883 Human

Entrez Gene: 19367 Mouse

Entrez Gene: 100361529 Rat

Omim: 603761 Human

SwissProt: Q99638 Human

SwissProt: Q9Z0F6 Mouse

Unigene: 655354 Human

Unigene: 277629 Mouse



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

Rad9有391個AA構成,Rad9有很多重要生物學功能,如:可調控DNA損傷反應、調節細胞的周期、對損傷的DNA進行修復、誘導細胞凋亡、調控部分基因的轉錄、具有3’端到5’端核酸外切酵素(exonuclease)的活性、促進核糖核酸的生合成以及參與胚胎發育過程。 曾有報道指出Rad9在調節細胞周期、誘導細胞凋亡及維持整個基因體的完整性等方面的生物功能都和p53極為相似,因此Rad9及p53這兩種蛋白在功能上可能具有相互協調作用。
版權所有 2004-2026 www.kastlife.cn 北京博奧森生物技術有限公司
通過國際質量管理體系ISO 9001:2015 GB/T 19001-2016    證書編號: 00124Q34771R2M/1100
通過國際醫療器械-質量管理體系ISO 13485:2016 GB/T 42061-2022    證書編號: CQC24QY10047R0M/1100
京ICP備05066980號-1         京公網安備110107000727號
主站蜘蛛池模板: 午夜视频福利在线 | 亚洲欧美日韩在线观看一区二区三区 | 久久久无码一区二区三区 | 精品麻豆一卡2卡三卡4卡乱码 | 久久精品成人免费观看三 | 扒开粉嫩的小缝喷白浆 | 亚洲成AV人片天堂网久久 | 在线a毛片 | 91精品国产色综合久久不卡98最新章节 | 色综合视频一区二区三区44 | 亚洲精品男女 | 九七资源站总站中文字幕 | 999国产在线 | 大地资源在线观看视频 | 日韩城人免费 | 国产精品成人一区二区三区吃奶 | 涩涩av| 大屁股人妻女教师撅着屁股 | 久日av | 精品在线观看一区二区三区 | 熟妇人妻无乱码中文字幕真矢织江 | 亚洲中文成人中文字幕 | 在线一区观看 | 91视频在线视频 | avtt香蕉久久 | 手机在线黄色网址 | 大地资源第二页中文高清版 | 人妻人人澡人人添人人爽 | 亚洲国产精品国自产拍久久 | 小尤奈无码视频 | 成人极品视频 | 波多野结衣永久免费视频 | 91亚洲影院 | 99在线在线视频免费视频观看 | 色八a级在线观看 | 国产精品免费视频二三区 | 日韩av一区二区三区四区 | 免费人成视频在线观看视频 | 免费又色又爽又黄的成人用品 | 黑人巨大精品欧美久久 | aⅴ小次郎改为av小四郎 |