97久久久精品综合88久久_亚洲国产精品一_久热热国产久热_97操操操_北条麻妃在线免费观看_精品国自产拍天天拍

掃碼關注公眾號           掃碼咨詢技術支持           掃碼咨詢技術服務
  
客服熱線:400-901-9800  客服QQ:4009019800  技術答疑  技術支持  質量反饋  關于我們  聯系我們
51午夜精品视频,丰满爆乳在线播放,久久精品国产日本波多野结衣
首頁 > 產品中心 > 標記一抗 > 產品信息
Rabbit Anti-phospho-MEF2D(Ser444)/Cy7 Conjugated antibody (bs-5502R-Cy7)
訂購熱線:400-901-9800
訂購郵箱:sales@bioss.com.cn
訂購QQ:  400-901-9800
技術支持:techsupport@bioss.com.cn
說 明 書: 100ul  
100ul/2980.00元
大包裝/詢價
產品編號 bs-5502R-Cy7
英文名稱 Rabbit Anti-phospho-MEF2D(Ser444)/Cy7 Conjugated antibody
中文名稱 Cy7標記的磷酸化肌細胞特異性增強因子2D抗體
別    名 MEF2D (phospho S444); p-MEF2D (phospho S444); MEF2D(phospho S444); DKFZp686I1536; MADS box transcription factor 2 polypeptide D; Mef2d; MEF2D_HUMAN; myocyte enhancer factor 2D; Myocyte specific enhancer factor 2, polypeptide D; Myocyte specific enhancer factor 2D; myocyte-specific enhancer factor 2D.   
規格價格 100ul/2980元 購買        大包裝/詢價
說 明 書 100ul  
產品類型 磷酸化抗體 
研究領域 心血管  免疫學  發育生物學  染色質和核信號  神經生物學  信號轉導  轉錄調節因子  表觀遺傳學  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應 Rat,  (predicted: Human, Mouse, Pig, Cow, Horse, Rabbit, )
產品應用
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 56kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated Synthesised phosphopeptide derived from human MEF2D around the phosphorylation site of Ser444
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產品介紹 background:
MEF2D is a member of the myocyte-specific enhancer factor 2 (MEF2) family of transcription factors. Members of this family are involved in control of muscle and neuronal cell differentiation and development, and are regulated by class II histone deacetylases. Fusions of the encoded protein with Deleted in Azoospermia-Associated Protein 1 (DAZAP1) due to a translocation have been found in an acute lymphoblastic leukemia cell line, suggesting a role in leukemogenesis. The encoded protein may also be involved in Parkinson disease and myotonic dystrophy. Alternative splicing results in multiple transcript variants.

Function:
Transcriptional activator which binds specifically to the MEF2 element, 5'-YTA[AT](4)TAR-3', found in numerous muscle-specific, growth factor- and stress-induced genes. Mediates cellular functions not only in skeletal and cardiac muscle development, but also in neuronal differentiation and survival. Plays diverse roles in the control of cell growth, survival and apoptosis via p38 MAPK signaling in muscle-specific and/or growth factor-related transcription. Plays a critical role in the regulation of neuronal apoptosis (By similarity).

Subunit:
Forms a complex with class II HDACs in undifferentiating cells. On myogenic differentiation, HDACs are released into the cytoplasm allowing MEF2s to interact with other proteins for activation. Interacts with HDAC4 (in undifferentiating cells); the interaction translocates MEF2D to nuclear dots. Forms a heterodimer with MEF2A.

Subcellular Location:
Nucleus. Note=Translocated by HDAC4 to nuclear dots.

Post-translational modifications:
Phosphorylated on Ser-444 by CDK5 is required for Lys-439 sumoylation and inhibits transcriptional activity. In neurons, enhanced CDK5 activity induced by neurotoxins promotes caspase 3-mediated cleavage leading to neuron apoptosis. Phosphorylation on Ser-180 can be enhanced by EGF. Phosphorylated and activated by CaMK4.
Acetylated on Lys-439 by CREBBP. Deacetylated by SIRT1.
Sumoylated on Lys-439 with SUMO2 but not SUMO1; which inhibits transcriptional activity and myogenic activity. Desumoylated by SENP3.
Proteolytically cleaved in cerebellar granule neurons on several sites by caspase 7 following neurotoxicity. Preferentially cleaves the CDK5-mediated hyperphosphorylated form which leads to neuron apoptosis and transcriptional inactivation (By similarity).

Similarity:
Belongs to the MEF2 family.
Contains 1 MADS-box domain.
Contains 1 Mef2-type DNA-binding domain.

Database links:
UniProtKB/Swiss-Prot: Q14814.1

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

MEF2D及其家族中的其他成員,在細胞存活、分化起著重要的作用。
版權所有 2004-2026 www.kastlife.cn 北京博奧森生物技術有限公司
通過國際質量管理體系ISO 9001:2015 GB/T 19001-2016    證書編號: 00124Q34771R2M/1100
通過國際醫療器械-質量管理體系ISO 13485:2016 GB/T 42061-2022    證書編號: CQC24QY10047R0M/1100
京ICP備05066980號-1         京公網安備110107000727號
主站蜘蛛池模板: 伊人黄网 | 欧美日韩国产人妻无码 | 久久精品亚洲精品无码金尊 | 美女内射无套日韩免费播放 | 国模芊芊大尺度啪啪 | 少妇乳大丰满在线播放 | 麻豆av传媒 | 亚洲AV永久无码一区 | 波多野结衣高潮喷水在线观看 | 日欧毛片 | 2020久天啪天天久久99久久 | 影音先锋中文字幕无码 | 成人精品久久一区二区三区 | 亚洲视频在线观看 | 成人做爰69片免费 | 国产亚洲精品麻豆一区二区 | 亚洲精品成人片在线播放4388 | 加勒比无码专区中文字幕 | 91老司机福利在线视频 | 欧美成人一区在线 | 亚洲欧美国产日韩精品 | 91视频.www| 久久精品国产99久久久 | 久久精品aⅴ无码中文字字幕 | 少妇激情AV一区二区三区 | 色欲精品国产一区二区三区AV | 日本啪啪网站永久免费 | 国产精品女同一区二区三区 | 高潮一区 | 白丝美女被操黄色视频国产免费 | 色综合久久天天综合网 | 1024最新合集 | 亚洲日韩一区精品射精 | 凹凸18禁在线视频 | 少妇仑乱A毛片 | 午夜精品久久久久9999高清 | 男女啪啪做爰高潮全过有网站 | 欧美A级毛欧美一级在线观看 | 人成在线免费网站 | 日本黄页网站免费观看 | 好大好硬好爽18禁视频免费 |