97久久久精品综合88久久_亚洲国产精品一_久热热国产久热_97操操操_北条麻妃在线免费观看_精品国自产拍天天拍

掃碼關注公眾號           掃碼咨詢技術支持           掃碼咨詢技術服務
  
客服熱線:400-901-9800  客服QQ:4009019800  技術答疑  技術支持  質量反饋  關于我們  聯系我們
欧美精品免费视频,国产AV永久无码精品网站,亚洲国产精品精华液999
首頁 > 產品中心 > 標記一抗 > 產品信息
Rabbit Anti-phospho-RAD51(Thr309)/HRP Conjugated antibody (bs-5677R-HRP)
訂購熱線:400-901-9800
訂購郵箱:sales@bioss.com.cn
訂購QQ:  400-901-9800
技術支持:techsupport@bioss.com.cn
說 明 書: 100ul  
100ul/2980.00元
大包裝/詢價
產品編號 bs-5677R-HRP
英文名稱 Rabbit Anti-phospho-RAD51(Thr309)/HRP Conjugated antibody
中文名稱 辣根過氧化物酶標記的磷酸化Rad51抗體
別    名 RAD51(phospho T309); BRCA1/BRCA2 containing complex, subunit 5; BRCC 5; BRCC5; DNA repair protein RAD51 homolog 1; DNA repair protein rhp51; E coli RecA homolog; HGNC:9817; Homolog of E coli RecA; homolog of S cerevisiae RAD51; HRAD51; HsRad51; HsT16930; Rad 51; RAD51 homolog (RecA homolog, E. coli) (S. cerevisiae); RAD51 homolog; RAD51 homolog S. cerevisiae; RAD51 S cerevisiae homolog; RAD51A; RECA; RecA homolog E. coli; RecA like protein; RecA, E. coli, homolog of; recombination protein A.   
規格價格 100ul/2980元 購買        大包裝/詢價
說 明 書 100ul  
產品類型 磷酸化抗體 
研究領域 腫瘤  免疫學  信號轉導  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應 Human,  (predicted: Mouse, Rat, Chicken, Dog, Pig, Cow, Rabbit, Sheep, )
產品應用 WB=1:500-2000 ELISA=1:100-1000 IHC-P=1:50-200 IHC-F=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 37kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated Synthesised phosphopeptide derived from human RAD51 around the phosphorylation site of Thr309 [GE(p-T)RI]
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產品介紹 background:
The protein encoded by this gene is a member of the RAD51 protein family. RAD51 family members are highly similar to bacterial RecA and Saccharomyces cerevisiae Rad51, and are known to be involved in the homologous recombination and repair of DNA. This protein can interact with the ssDNA-binding protein RPA and RAD52, and it is thought to play roles in homologous pairing and strand transfer of DNA. This protein is also found to interact with BRCA1 and BRCA2, which may be important for the cellular response to DNA damage. BRCA2 is shown to regulate both the intracellular localization and DNA-binding ability of this protein. Loss of these controls following BRCA2 inactivation may be a key event leading to genomic instability and tumorigenesis. Two alternatively spliced transcript variants of this gene, which encode distinct proteins, have been reported. Transcript variants utilizing alternative polyA signals exist.

Function:
Participates in a common DNA damage response pathway associated with the activation of homologous recombination and double-strand break repair. Binds to single and double stranded DNA and exhibits DNA-dependent ATPase activity. Underwinds duplex DNA and forms helical nucleoprotein filaments. Plays a role in regulating mitochondrial DNA copy number under conditions of oxidative stress in the presence of RAD51C and XRCC3.

Subcellular Location:
Nucleus. Cytoplasm. Cytoplasm, perinuclear region. Mitochondrion matrix. Note=Colocalizes with RAD51AP1 and RPA2 to multiple nuclear foci upon induction of DNA damage. DNA damage induces an increase in nuclear levels.

Tissue Specificity:
Highly expressed in testis and thymus, followed by small intestine, placenta, colon, pancreas and ovary. Weakly expressed in breast.

Post-translational modifications:
Phosphorylated. Phosphorylation of Thr-309 by CHEK1 may enhance association with chromatin at sites of DNA damage and promote DNA repair by homologous recombination. Phosphorylation by ABL1 inhibits function.

DISEASE:
Defects in RAD51 are a cause of susceptibility to breast cancer (BC) [MIM:114480]. A common malignancy originating from breast epithelial tissue. Breast neoplasms can be distinguished by their histologic pattern. Invasive ductal carcinoma is by far the most common type. Breast cancer is etiologically and genetically heterogeneous. Important genetic factors have been indicated by familial occurrence and bilateral involvement. Mutations at more than one locus can be involved in different families or even in the same case.

Similarity:
Belongs to the RecA family. RAD51 subfamily.
Contains 1 HhH domain.

Database links:

Entrez Gene: 5888 Human

Entrez Gene: 19361 Mouse

Entrez Gene: 499870 Rat

Omim: 179617 Human

SwissProt: Q06609 Human

SwissProt: Q08297 Mouse

Unigene: 631709 Human

Unigene: 330492 Mouse

Unigene: 20474 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

Rad51蛋白對細胞調節有重要作用:作為輔助因子參與DNA修復同源重組,維持正常細胞周期;Rad51蛋白在很多組織中都有不同的存在。在乳腺癌和消化系統等惡性腫瘤組織中表達較高,究其原因有報道稱:這是DNA被損傷后細胞的一種反應,而這種反應不足以阻止癌變的發生。
版權所有 2004-2026 www.kastlife.cn 北京博奧森生物技術有限公司
通過國際質量管理體系ISO 9001:2015 GB/T 19001-2016    證書編號: 00124Q34771R2M/1100
通過國際醫療器械-質量管理體系ISO 13485:2016 GB/T 42061-2022    證書編號: CQC24QY10047R0M/1100
京ICP備05066980號-1         京公網安備110107000727號
主站蜘蛛池模板: 国产精品成 | 欧美日韩精品一区 | 伊人久久综合一区二区 | 91看片| 亚洲国产精品va在线 | 天天干天天插天天 | 欧美日韩精品一区二区三区四区 | 天天综合网网欲色 | 韩国19禁无遮挡啪啪无码网站 | 国产精品国产三级国AV在线观看 | 国产真实老熟女无套内射 | 97人妻熟女成人免费视频 | 国产下药迷晕一区二区三区在线看 | 欧美黄色性生活视频 | 亚洲综合无码久久精品综合 | 狠狠躁躁夜夜躁波多野结依 | 久久久国产精品 | 国内外精品激情刺激在线 | 91精品少妇高潮一区二区三区不卡 | 麻豆人妻无码性色av专区 | 日韩亚州| 亚洲中文字幕无码久久 | 51成人| 中文字幕亚洲综合久久菠萝蜜 | 4399伦理片 | 每日更新在线观看 | 亚洲爆乳少妇无码激情 | 国产一级片大全 | 国产性xxxx18免费观看视频 | 97影院网| 日韩aⅴ一区二区三区 | 欧美成人一区二区三区在线观看 | 伊人成色综合网 | 偷妻无码一区二区三区动漫 | 十八禁羞羞视频爽爽爽 | 国产一区二区精品久 | 亚洲日本高清成人aⅴ片 | 日韩小片 | 人与禽交videos欧美 | 欧美在线观看视频 | 性屋娱乐wwwsex5me |